Johannes Hell, Ph.D. for UC Davis Health

Johannes Hell, Ph.D.

Professor

Reviews

Specialties

Pharmacology

Department

Pharmacology

Locations and Contact

Genome & Biomedical Sciences Facility

451 Health Sciences Drive
Davis, CA 95616

Get Directions

Additional Numbers

Physician Referrals

800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Johannes Hell's research interests are molecular mechanisms of synaptic transmission, attention, and attention deficit.

Division

Pharmacology

Undergraduate School

B.S., Biochemistry, University of Tübingen, Tübingen, Germany 1983

Other School

Ph.D., Neuroscience, University of Munich, Munich, Germany 1991

Other School

M.S., Biochemistry, University of Tübingen, Tübingen, Germany 1987

WM Keck Foundation Award, 2020

Section Head (formerly P. DeCamilli and B. Hille): F1000Prime, Neuronal Signaling Mechanisms (2016 - present),

Editorial Board Member, Scientific Reports, Nature Press (2015 - present),

F1000 Member of the Year in Neuroscience, 2013, 2014, 2015

Editorial Board Member, F1000 Research open access journal (2012 - present),

See Complete list of publications

Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 Jan 22;128(2):246-261. doi:10.1161/CIRCRESAHA.120.317452. Epub 2020 Nov 13. PMID:33183171.

Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 Oct 20;11(1):5303. doi:10.1038/s41467-020-18947-y. PMID:33082339.

Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. α-Actinin-1 promotes activity of the L-type Ca2+ channel Cav 1.2. EMBO J. 2020 Mar 2;39(5):e102622. doi:10.15252/embj.2019102622. Epub 2020 Jan 27. Erratum in: EMBO J. 2020 Sep 15;39(18):e106171. PMID:31985069.

Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 Oct 14;8:e49464. doi:10.7554/eLife.49464. PMID:31609201.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 Jun 4;129(8):3140-3152. doi:10.1172/JCI124705. PMID:31162142.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 1;8:e42214. doi:10.7554/eLife.42214. PMID:30821687.

Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018 May 16;98(4):783-800.e4. doi:10.1016/j.neuron.2018.03.049. Epub 2018 Apr 26. PMID:29706584.

Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 Mar 13;9(1):1050. doi:10.1038/s41467-018-03459-7. PMID:29535304.

Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, Mohapatra D, Horne MC, Ames JB, Hell JW. α-Actinin Anchors PSD-95 at Postsynaptic Sites. Neuron. 2018 Mar 7;97(5):1094-1109.e9. doi:10.1016/j.neuron.2018.01.036. Epub 2018 Feb 8. PMID:29429936.