Madeline Nieves-Cintron, Ph.D. for UC Davis Health

Madeline Nieves-Cintron, Ph.D.

Assistant Professor, Department of Pharmacology



Molecular, Cellular, and Integrative Physiology



Locations and Contact

UC Davis Medical Center

UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817

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Research/Academic Interests

Research in Dr. Nieves-Cintron lab aims to elucidate mechanisms regulating vascular function in health and disease. She studies vascular smooth muscle ion channels, emphasizing ionic control of intracellular calcium and smooth muscle contractility, for their responses to health-relevant conditions such as diabetes, hypertension, and environmental pollutants.



Undergraduate School

B.S., Biology, University of Puerto Rico, San Juan PR 1999

Other School

Ph.D., Biology, University of Puerto Rico, San Juan PR 2004


Physiology & Biophysics, University of Washington, Seattle WA 2005-2010

Center for the Advancement of Multicultural Perspectives on Science (CAMPOS) Scholar Award, 2019

International Symposium on Resistance Arteries Best Poster Presentation Award, 2017

National Institute of Health: Minority Biomedical Research Support: Research Initiative for Scientific Enhancement Research Fellowship (5R25GM61151) 2002, 2003, 2004

SACNAS Travel Award 2002, 2003

Minority Access to Research Career Travel Award, 2001

To view a complete list of Dr. Nieves-Cintron's publications, please click here.

Le T, Martín-Aragón Baudel M, Syed A, Singhrao N, Pan S, Flores-Tamez VA, Burns AE, Man KNM, Karey E, Hong J, Hell JW, Pinkerton KE, Chen CY, Nieves-Cintrón M. Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries. Function (Oxf). 2021 Aug 19;2(5):zqab041. doi:10.1093/function/zqab041. PMID:34553140.

Nieves-Cintrón M, Flores-Tamez VA, Le T, Baudel MM, Navedo MF. Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle. Cell Mol Life Sci. 2021 Jan;78(1):31-61. doi:10.1007/s00018-020-03582-z. Epub 2020 Jun 27. PMID:32594191.

Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2. Nat Commun. 2020 Oct 20;11(1):5303. doi:10.1038/s41467-020-18947-y. PMID:33082339.

Martin-Aragon Baudel M, Espinosa-Tanguma R, Nieves-Cintron M, Navedo MF. Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells. Front Endocrinol (Lausanne). 2020 May 22;11:329. doi:10.3389/fendo.2020.00329. PMID:32528416.

Syed AU, Lee T, Navedo MF, Nieves-Cintrón M. Ion channels and their regulation in vascular smooth muscle. Shad KF, Luqman N, Saeedi Saravi SS, (eds). Basic and Clinical Understanding of Microcirculation, London, UK: IntechOpen. 2019 Oct 3. doi:10.5772/intechopen.88962.

Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 1;8:e42214. doi:10.7554/eLife.42214. PMID:30821687.

Nieves-Cintron M, Tajada S, Santana LF, Navedo MF. Total Internal Reflection Fluorescent Microscopy in vascular smooth muscle. Methods in Signal Transduction: Vascular Smooth Muscle, 1st edition, CRC Press, Boca Raton FL. 2018:87-103.

Nieves-Cintrón M, Syed AU, Nystoriak MA, Navedo MF. Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation. 2018 Jan;25(1):10.1111/micc.12423. doi:10.1111/micc.12423. PMID:29044853.

Morotti S, Nieves-Cintrón M, Nystoriak MA, Navedo MF, Grandi E. Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia. Channels (Austin). 2017 Jul 4;11(4):340-346. doi:10.1080/19336950.2017.1293220. Epub 2017 Feb 10. Erratum for: Addendum to: Nystoriak MA, Nieves-Cintron M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, et al. Ser1928 phosphorylation by PKA stimulates L-type CaV1.2 channel and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling 10 eaaf9647. 2017. doi:10.1126/scisignal.aaf9647. PMID:28631947.