Vladimir Yarov-Yarovoy, Ph.D.
Professor
Locations and Contact
UC Davis Medical Center
UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817
Phone: 800-2-UCDAVIS (800-282-3284)
Research/Academic Interests
My research interests and expertise encompass neuroscience, protein structure, computational biology, and evolution. Main focus of my research group is on structure and function studies of voltage-gated ion channels, computational design and chemical synthesis of subtype-specific modulators of voltage-gated ion channels, development of computational methods for membrane protein structure prediction and design, and analysis of evolution of human voltage-gated ion channels.
Undergraduate School
M.S., Physics, Moscow State University, Moscow, Russia 1993
Medical School
Ph.D., Biochemistry and Molecular Biology, Oregon Health Science University, Portland OR 1998
Other School
Postdoc, Computational Biology and Biophysics, University of Washington, Seattle WA 2003
Featured article in University of California News. https://www.universityofcalifornia.edu/news/turning-tarantula-venom-pain-relief, 2021
UC Davis Academic Senate Faculty Research Grant Award, 2015, 2016, 2017, 2018
University of Washington Royalty Research Fund Award, 2008, 2009
NIH Research Career Development Award, 2003, 2004, 2005, 2006, 2007, 2008, 2009
Biophysical Society Graduate Student Travel Award, 1998
Mateos DL, Yarov-Yarovoy V. Structural modeling of peptide toxin-ion channel interactions using RosettaDock. Proteins. 2023 Feb 2. doi:10.1002/prot.26474. Epub ahead of print. PMID:36729043.
Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. Molecular Determinants of μ-Conotoxin KIIIA interaction with the Voltage-Gated Sodium Channel Nav1.7. bioRxiv. 2023. doi:10.1101/654889.
Nguyen PT, Nguyen HM, Wagner KM, Stewart RG, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, Wulff H, Yarov-Yarovoy V. Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain. Elife. 2022 Dec 28;11:e81727. doi:10.7554/eLife.81727. PMID:36576241.
Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Front Pharmacol. 2022 Sep 16;13:966463. doi:10.3389/fphar.2022.966463. PMID:36188564.
Nguyen PT, Yarov-Yarovoy V. Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels. Front Pharmacol. 2022 Jan 27;13:842032. doi:10.3389/fphar.2022.842032. PMID:35153801.
Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J. New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket. Elife. 2020 Nov 9;9:e62039. doi:10.7554/eLife.62039. PMID:33164749.
Craig RA 2nd, Garrison CE, Nguyen PT, Yarov-Yarovoy V, Du Bois J. Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels. ACS Chem Neurosci. 2020 Feb 5;11(3):418-426. doi:10.1021/acschemneuro.9b00621. Epub 2020 Jan 17. PMID:31951114.
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi:10.1038/s41573-019-0013-8. PMID:30728472.
Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2945-2954. doi:10.1073/pnas.1817446116. Epub 2019 Feb 6. PMID:30728299.
Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol. 2017 Apr;91(4):392-402. doi:10.1124/mol.116.108068. Epub 2017 Jan 26. PMID:28126850.