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Manuel F. Navedo-Morales, Ph.D., F.A.H.A.
Professor
Locations and Contact
Research/Academic Interests
Research in the Navedo Lab aims to determine the cellular and molecular mechanisms regulating arterial smooth muscle excitability and vascular reactivity. Innovative techniques and approaches are used to specifically examine the mechanisms by which local and global signals regulate excitation-contraction coupling and excitation-transcription coupling in arterial smooth muscle cells during physiological and pathological conditions such as hypertension, diabetes, and Alzheimer's disease. The overarching objective is to uncover regulatory signaling pathways of vascular (dys)function that could help identify new targets for exploitation as novel therapeutic interventions to treat vascular complications.
Division
Pharmacology
Undergraduate School
B.S., General Biology, University of Puerto Rico, San Juan PR 1998
Other School
Ph.D., Neurobiology, University of Puerto Rico, San Juan PR 2003
Fellowship
Physiology and Biophyics, University of Washington, Seattle WA 2004-2007
Visiting Professor at Vermont Center for Cardiovascular and Brain Health, 2022
Lab Safety Award, 2021
Fellow of the American Heart Association, 2019
UCD Academic Senate Research Travel Award, 2016
To view a complete list of Dr. Navedo's publications, please click here.
Ren L, Thai PN, Gopireddy RR, Timofeyev V, Ledford HA, Woltz RL, Park S, Puglisi JL, Moreno CM, Santana LF, Conti AC, Kotlikoff MI, Xiang YK, Yarov-Yarovoy V, Zaccolo M, Zhang XD, Yamoah EN, Navedo MF, Chiamvimonvat N. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight. 2022 Nov 22;7(22):e162602. doi:10.1172/jci.insight.162602. PMID:36509290.
Martín-Aragón Baudel M, Flores-Tamez VA, Hong J, Reddy GR, Maillard P, Burns AE, Man KNM, Sasse KC, Ward SM, Catterall WA, Bers DM, Hell JW, Nieves-Cintrón M, Navedo MF. Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation. Circ Res. 2022 Dec 2;131(12):1018-1033. doi:10.1161/CIRCRESAHA.122.321479. Epub 2022 Nov 8. PMID:36345826.
Reddy GR, Ren L, Thai PN, Caldwell JL, Zaccolo M, Bossuyt J, Ripplinger CM, Xiang YK, Nieves-Cintrón M, Chiamvimonvat N, Navedo MF. Deciphering cellular signals in adult mouse sinoatrial node cells. iScience. 2021 Dec 25;25(1):103693. doi:10.1016/j.isci.2021.103693. PMID:35036877.
Nieves-Cintrón M, Flores-Tamez VA, Le T, Baudel MM, Navedo MF. Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle. Cell Mol Life Sci. 2021 Jan;78(1):31-61. doi:10.1007/s00018-020-03582-z. Epub 2020 Jun 27. PMID:32594191.
Nieves-Cintron M, Santana LF, Navedo MF. TRPML1ng on sparks. Sci Signal. 2020 Jun 23;13(637):eabc0993. doi: 10.1126/scisignal.abc0993. PMID:32576679.
Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 Jun 4;129(8):3140-3152. doi:10.1172/JCI124705. PMID:31162142.
Prada MP, Syed AU, Buonarati OR, Reddy GR, Nystoriak MA, Ghosh D, Simó S, Sato D, Sasse KC, Ward SM, Santana LF, Xiang YK, Hell JW, Nieves-Cintrón M, Navedo MF. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife. 2019 Mar 1;8:e42214. doi:10.7554/eLife.42214. PMID:30821687.
Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal. 2017 Jan 24;10(463):eaaf9647. doi:10.1126/scisignal.aaf9647. PMID:28119464.