Manuel Navedo, Ph.D.

Specialties

Ion Channel Physiology

Pharmacology

Vascular Biology

Electrophysiology

Calcium Imaging

Physiology

Department

Pharmacology

Title

Professor

Reviews

Location, Directions and Contact Info

Genome and Biomedical Sciences Building

451 Health Sciences Drive, Suite 3503
Davis, CA 95616
Driving Directions

Primary Phone:
530-752-3200

Research/Academic Interests

Cellular and molecular mechanisms regulating arterial smooth muscle excitability The main goal of my research team is to understand the mechanisms by which local and global calcium signals regulate excitation-contraction coupling and excitation-transcription coupling in arterial smooth muscle cells during physiological and pathological conditions. To tackle these issues, we employ several state-of-the-art techniques including molecular biology, patch-clamp electrophysiology, and confocal and Total Internal Reflections Fluorescence (TIRF) microscopy. We are currently interested in determining the mechanisms by which hyperglycemia induces the activation of a novel calcium signaling modality (persistent calcium sparklets) in arterial smooth muscle. We think that activation of this signal contributes to enhanced contractility and arterial dysfunction during diabetes.

Graduate Group Affiliations:

Pharmacology and Toxicology Graduate Program

Molecular, Cellular and Integrative Physiology Graduate Program

Funding Sources:

National Institutes of Health

American Heart Association

Education

Ph.D., University of Puerto Rico, Rio Piedras

B.S., University of Puerto Rico, Rio Piedras

Fellowships

Vascular Biology, University of Washington, Seattle WA

Select Recent Publications

To view a complete list of Dr. Navedo's publications, please click here.

MF Navedo*, GC Amberg. Local regulation of L-type calcium channels in arterial smooth muscle. Microcirculation 2013; 20: 290-298. *corresponding author. PMC3577995

M Nieves-Cintrón, MA Nystoriak, MP Prada, K Johnson, W Fayer, ML Dell’Acqua, JD Scott, MF Navedo. Selective downregulation of KV2.1 function contributes to enhanced arterial tone during diabetes. JBC 2015; 290: 7918-7929. PMC4367290

MA Nystoriak, M Nieves-Cintron, MF Navedo. Capturing single L-type calcium channel function with optics. Biochimica Biophysical Acta 2013; 1833: 1657-1664. PMC3574202

MA Nystoriak, M Nieves-Cintrón, PJ Nygren, SA Hinke, CB Nichols, CY Chen, JL Puglisi, L Izu, DM Bers, ML Dell'Acqua, JD Scott, LF Santana, MF Navedo. AKAP150 contributes to enhanced vascular tone by facilitating BKCa channel remodeling in hyperglycemia and diabetes. Circulation Research 2014; 114: 607-615. This article is accompanied by an editorial highlighting the novel aspects of the study. PMC3954117.

ZA Malik, IS Stein, MF Navedo, JW Hell. Mission CaMKIIγ: Shuttle calmodulin from membrane to nucleus. Cell 2014; 159: 235-237. PMC in progress.

RE Dixon, C Moreno, C Yuan, X Optiz-Araya, M Binder, MF Navedo* LF Santana*. Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels. eLife 4 2015. *co-corresponding author. PMC4360655