Waldau Lab | Neurological Surgery | UC Davis Health

Waldau Lab

waldau lab and team
  • Ben Waldau, M.D.
    Principal Investigator

    Ben Waldau, M.D.

    Ben Waldau, M.D., is a cerebrovascular and endovascular neurosurgeon at UC Davis. Waldau spent several years exclusively devoted to basic science research with Dr. Steven Goldman on oligodendrocyte progenitor transcriptome research, Dr. Ashok Shetty on treatment of a rodent epilepsy model and Dr. Gerd Kempermann on dentate neurogenesis research. At UC Davis, Waldau completed a Master of Advanced Studies in Clinical Research as part of his K08 mentoring plan; this degree included courses in preclinical and clinical statistics, research ethics and grant writing, among other courses. 

    Waldau’s lab was one of the first to publish on vascularization of human brain organoids with human endothelial cells, and the manuscript has been cited more than 500 times. His lab has also created a rodent model of subarachnoid and intraventricular hemorrhage with transient intracranial pressure (ICP) elevation that leads to spatial memory deficits and is used to model cognitive outcomes in subarachnoid hemorrhage survivors.

  • Research Goals

    The Waldau Lab investigates mechanisms of cognitive decline after aneurysmal rupture. The lab has established a rodent model of intraventricular and subarachnoid hemorrhage that results in spatial memory deficits in Morris water maze. The team is examining the effects of transient intracranial pressure (ICP) spikes on cognitive outcomes and studies the complement cascade and sterile neuro-inflammation as causes. The team also studies human cortical brain organoids, their vascularization and biological effects on chronic stroke.

  • Current Projects

    • Mechanism of memory decline after subarachnoid and intraventricular hemorrhage
    • Transplantation of cortical human brain organoids for the treatment of stroke