Caren Armstrong has a particular interest in how surgical interventions can be used clinically to help treat children with seizures. She has additional training in epilepsy surgical management, as well as in neuromodulation, and neurogenetics in the context of epilepsy.
The laboratory investigates the underlying mechanisms that govern the development of and treatments for epilepsy in children. This includes:
- EEG analysis of seizures and seizure markers in patients and in mouse models
- The use of intracranial stimulation to actively probe the network in patients undergoing intracranial EEG
- The use of neuromodulation for seizures
- Mechanisms of genetic epilepsies
- Specific inhibitory interneuronal microcircuits underlying seizure initiation
To investigate, we use analysis of EEG recordings and medical record data from patients, record directly from brain tissue and cells from resected human tissue and animal models of epilepsy.