Gray Lab | Neurology Research

I am interested in understanding the molecular and cellular mechanisms involved in synapse function and plasticity and how these processes may be disrupted in neurological and psychiatric disorders. I earned my PhD in the laboratory of Bryan Roth at Case Western Reserve University (now at UNC) examining the mechanisms underlying the desensitization and downregulation of serotonin 5-HT2A receptors, the primary target of serotonergic psychedelics such as LSD and psilocybin. Then, during my clinical training in psychiatry at the University of California, San Francisco, I became interested in the synaptic basis of neuropsychiatric disorders and pursued postdoctoral research in the laboratory of Roger Nicoll, examining synapse development and the role of a key glutamate receptor, the NMDA receptor, which is also the primary target of the dissociative anesthetic and rapid-acting antidepressant ketamine. As a psychiatrist and synaptic biologist, my laboratory is interested in fundamental questions of synapse biology both at the basic science level as well as understanding how subtle disruptions of these synaptic mechanisms can lead to the development of brain disorders such as schizophrenia, autism, and Alzheimer’s disease.