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Tsung-Yu Chen, M.D., Ph.D.
Professor
Locations and Contact
Research/Academic Interests
Dr. Chen's long-term interest is to understand structures, functions, and physiological roles of a class of transmembrane proteins called ion channels. These proteins control ion fluxes across cell membranes, and in doing so maintain normal physiological functions, such as conduction of nerve impulses, secretion of hormones and neurotransmitters, and maintaining cardiac rhythm. His recent work has been focused on two types of ion channels, the CLC chloride channels (CLC, for Cl- Channels) and cyclic nucleotide-gated (CNG) channels.
Division
Neurology
Center/Program Affiliation
Medical School
M.D., National Yang-Ming Medical School, Taipei 1986
Other School
Ph.D., Johns Hopkins University School of Medicine, Baltimore MD 1994
Internship
National Yang-Ming Medical School/Veteran General Hospital-Taipei, Taipei 1984-1986
Fellowship
Brandeis University, Ealtham MA 1994-1996
Paul F. Cranefield Award, Society of General Physiologists, 2004
Michael A. Shanoff Research Award, Johns Hopkins University School of Medicine, 1994
Scholarship of Ministry of Education, Taiwan, 1989
Shun-Ro In Research Award, Yang-Ming Medical College, Taiwan., 1988
Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY. CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells. 2020 May 26;9(6):1332. doi:10.3390/cells9061332. PMID:32466489.
Nguyen DM, Chen LS, Jeng G, Yu WP, Chen TY. Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation. PLoS One. 2020 Apr 17;15(4):e0231812. doi:10.1371/journal.pone.0231812. PMID:32302365.
Xu P, Choo YM, Chen Z, Zeng F, Tan K, Chen TY, Cornel AJ, Liu N, Leal WS. Odorant Inhibition in Mosquito Olfaction. iScience. 2019 Sep 27;19:25-38. doi:10.1016/j.isci.2019.07.008. Epub 2019 Jul 12. PMID:31349189.
Nguyen DM, Chen LS, Yu WP, Chen TY. Comparison of ion transport determinants between a TMEM16 chloride channel and phospholipid scramblase. J Gen Physiol. 2019 Apr 1;151(4):518-531. doi:10.1085/jgp.201812270. Epub 2019 Jan 22. PMID:30670476.
Peng YJ, Lee YC, Fu SJ, Chien YC, Liao YF, Chen TY, Jeng CJ, Tang CY. FKBP8 Enhances Protein Stability of the CLC-1 Chloride Channel at the Plasma Membrane. Int J Mol Sci. 2018 Nov 28;19(12):3783. doi:10.3390/ijms19123783. PMID:30487393.
O'Halloran DM, Altshuler-Keylin S, Zhang XD, He C, Morales-Phan C, Yu Y, Kaye JA, Brueggemann C, Chen TY, L'Etoile ND. Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans. Sci Rep. 2017 Mar 13;7(1):169. doi:10.1038/s41598-017-00126-7. PMID:28279024.
Jeng G, Aggarwal M, Yu WP, Chen TY. Independent activation of distinct pores in dimeric TMEM16A channels. J Gen Physiol. 2016 Nov;148(5):393-404. doi:10.1085/jgp.201611651. Epub 2016 Oct 17. PMID:27799319.
Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY. Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci Rep. 2016 Sep 1;6:32444. doi:10.1038/srep32444. PMID:27580824.
Riisager A, de Paoli FV, Yu WP, Pedersen TH, Chen TY, Nielsen OB. Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating. J Physiol. 2016 Jun 15;594(12):3391-406. doi:10.1113/JP271556. Epub 2016 Mar 20. PMID:26857341.
Yu Y, Tsai MF, Yu WP, Chen TY. Modulation of the slow/common gating of CLC channels by intracellular cadmium. J Gen Physiol. 2015 Dec;146(6):495-508. doi:10.1085/jgp.201511413. PMID:26621774.