Alexandra O'neill Duffy, D.O. for UC Davis Health

Alexandra O'neill Duffy, D.O.

Director, Neurology Residency Program

Associate Clinical Professor

To see if Alexandra O'neill Duffy is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).




Movement Disorders



Locations and Contact

Midtown Sleep Lab/Neurophysiology

3160 Folsom Blvd
Sacramento, CA 95816

Get Directions

Additional Numbers

Clinic Phone


Physician Referrals

800-4-UCDAVIS (800-482-3284)

Philosophy of Care

Dr. Duffy believes in a strong therapeutic alliance with her patients, staying knowledgeable of contemporary and emerging therapies, and teaching through the care she provides her patients. She is also a wife, mama of two boys and loves to go fly fishing with her family.

Clinical Interests

Dr. Duffy specializes in movement disorders seeing patients with Parkinson’s disease and atypical parkinsonism, Tremors, Dystonia and Huntington’s disease. She is trained in Deep Brain Stimulation and Botulinum Toxin Injections for treatment of movement disorders.

Research/Academic Interests

Dr. Duffy’s research interests are focused on participating in clinical trials in Huntington’s disease. She also dedicates her time as the Neurology Residency Program Director mentoring and teaching the next generation of neurologists.



Center/Program Affiliation

UC Davis Medical Group

Undergraduate School

B.S., UC Davis, Sacramento CA 2003

Medical School

D.O., Touro University College of Osteopathic Medicine, Vallego CA 2010


Internal Medicine, Alameda County Medical Center, Alameda CA 2010-2011


Neurology, UC Davis Health, Sacramento CA 2011-2014


Neurology, UC Davis Health, Sacramento CA 2014-2015

Huntington’s Disease Society of America Team Hope Walk Appreciation Award, September, 2019

UC Davis Neurology Residency Graduation Award: Senior Residents Appreciation Award, 2017, 2018

UC Davis Neurology Residency Graduation Award: Outstanding Movement Disorder Faculty, 2015, 2016

UC Davis Neurology Residency Graduation Awards: Chief Residents Appreciation Award, 2014, 2015

UC Davis Neurology Residency Graduation Awards: Excellence in Professionalism, 2013, 2014

American Academy of Neurology Institute's 2014 Annual Meeting Resident Scholarship, 2014

Hart K, Duffy A. Late-onset Huntington’s Disease: A Retrospective Review of 38 Cases. American Academy of Neurology. 2020 Annual Meeting. Virtual Presentation.

Markun L, Zhang L, Duffy A, Dayananthan J, Wheelock V. High intensity onabotulinumtoxin - A therapy for the management of severe dystonia in Juvenile-onset Huntington’s disease. Huntington Study Group Annual meeting 2019. Sacramento, CA.

Chen D, Green T, Maselli R, Lenaerts M, Duffy A, Xiong G. Easily Missed Diagnosis – Multifocal Motor Neuropathy with Three Cases. UC Irvine Health Neuromuscular Colloquium 2019. Huntington Beach, CA.

Moreno G, Ng K, Duffy A. Hypertrophic Olivary Degeneration. Annual 2017 Movement Disorders Society Meeting. Vancouver, Canada.

Yuan M, Sperry L, Malhado-Chang N, Duffy A, Wheelock V, Farias S, O’Connor K, Olichney J, Shahlaie K, Zhang L. Atypical Antipsychotic Therapy. Parkinson’s Disease Psychosis: A Retrospective Study. Brain and Behavior. 2017 Apr 14. Doi:10.1002/brb3.639.

Yuan M, Sperry L, Malhado-Chang N, Duffy A, Wheelock V, Farias S, O’Connor K, Olichney J, Shahlaie K, Zhang L. Atypical Antipsychotic Therapy in Parkinson’s Disease Psychosis: A Retrospective Study. 4th World Parkinson’s Congress.

Duffy A. Remembering. Neurology. 2016 May 24. doi:10.1212/WNL.0000000000002692.

Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Wheelock V, Segal DJ, Nolta JA. Allele-specific reduction of the mutant huntingtin allele using transcription activator-like effectors in human Huntington's disease fibroblasts. Cell Transplant. 2016 Feb 4. [Epub ahead of print]. PMID:26850319.

Pollock K, Dahlenburg H, Nelson H, Fink KD, Cary W, Hendrix K, Annett G, Torrest A, Deng P, Gutierrez J, Nacey C, Pepper K, Kalomoiris S, Anderson JD, McGee JL, Gruenloh W, Fury B, Bauer G, Duffy A, Tempkin T, Wheelock V and Nolta, JA. Human Mesenchymal Stem Cells Genetically Engineered to Overexpress Brain-derived Neurotrophic Factor Improve Outcomes in Huntington’s disease Mouse Models. Mol Ther. 2016 Jan 14. doi:10.1038/mt.2016.12. [Epub ahead of print] PMID:26765769.

Duffy A, Sifry-Platt M, Tempkin T, Wheelock V. Protecting privacy in Huntington’s disease predictive testing: A survey of Attitudes, Beliefs and Concerns. Eighth Annual Huntington’s disease Clinical Research Symposium, Minneapolis MN, November 2014. Neurotherapeutics. 2015;12(1):263-284.