JoAnne E. Natale, M.D., Ph.D. for UC Davis Health

JoAnne E. Natale, M.D., Ph.D.

Vice Chair for Quality and Safety, Department of Pediatrics

UC Davis Children's Hospital Director Quality & Safety

Associate Chief Medical Officer for Children's Health

Clinical Professor, Department of Pediatrics

JoAnne E. Natale is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).



Pediatric Critical Care



Locations and Contact

UC Davis Children's Hospital

2315 Stockton Blvd.
Sacramento, CA 95817

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Additional Numbers

Clinic Phone


Physician Referrals

800-4-UCDAVIS (800-482-3284)

Philosophy of Care

Together with their family, my goal is to compassionately provide outstanding care to assure the best possible future for each critically ill child.

Clinical Interests

My clinical interests include healthcare quality, patient safety, and effective and compassionate communication in pediatrics.

Research/Academic Interests

My research and academic interests include pediatric traumatic brain injury, standardizing pediatric inpatient care to optimize safety and quality, and enhancing pediatric outcomes through efficient, effective and high-value care.


Pediatric Critical Care

Center/Program Affiliation

UC Davis Children's Hospital

Undergraduate School

B.S., Pediatrics, Allentown College, Center Valley PA 1984

Medical School

M.D., Pediatrics, Michigan State University, East Lansing MI 1993

Other School

Ph.D., Physiology, University of Michigan Medical School, Ann Arbor MI 1988


Pediatrics, Albert Einstein/Montefiore Medical Center, Bronx NY 1993-1994


Pediatrics, Albert Einstein/Montefiore Medical Center, Bronx NY 1994-1996


Pediatric Critical Care, Johns Hopkins Hospital, Baltimore MD 1996-1999

Society for Critical Care Medicine 2017 Star Research Achievement Award,

UC Davis Medical Center Chief of Staff Award, 2015

Dean's Team Award for Excellence in Clinical Care, 2012

Fellow, University of California Office of the President Center for Healthcare Quality and Innovation, 2012, 2013, 2014

Ambassador of Diversity, UC Davis Health System, 2008

Huang JX, Colwell B, Vadlaputi P, Sauers-Ford H, Smith BJ, McKnight H, Witkowski J, Padovani A, Aghamohammadi S, Tzimenatos L, Beck Rn S, Reneau K, Nill B, Harbour D, Pegadiotes J, Natale J, Hamline M, Siefkes H. Protocol-Driven Initiation and Weaning of High-Flow Nasal Cannula for Patients With Bronchiolitis: A Quality Improvement Initiative. Pediatr Crit Care Med. 2023 Feb 1;24(2):112-122. doi:10.1097/PCC.0000000000003136. Epub 2022 Dec 16. PMID:36661418. 

Lam JY, Shimizu C, Tremoulet AH, Bainto E, Roberts SC, Sivilay N, Gardiner MA, Kanegaye JT, Hogan AH, Salazar JC, Mohandas S, Szmuszkovicz JR, Mahanta S, Dionne A, Newburger JW, Ansusinha E, DeBiasi RL, Hao S, Ling XB, Cohen HJ, Nemati S, Burns JC; Pediatric Emergency Medicine Kawasaki Disease Research Group; CHARMS Study Group. A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation study. Lancet Digit Health. 2022 Oct;4(10):e717-e726. doi:10.1016/S2589-7500(22)00149-2. PMID:36150781.

Bell MJ, Rosario BL, Kochanek PM, Adelson PD, Morris KP, Au AK, Schober M, Butt W, Edwards RJ, Zimmerman J, Pineda J, Le TM, Dean N, Whalen MJ, Figaji A, Luther J, Beers SR, Gupta DK, Carpenter J, Buttram S, Wisniewski SR; Approaches and Decisions for Acute Pediatric TBI (ADAPT) Investigators. Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022 Jul 1;5(7):e2220969. doi:10.1001/jamanetworkopen.2022.20969. Erratum in: JAMA Netw Open. 2022 Aug 1;5(8):e2232865. PMID:35802371.

Rudolph MW, Kneyber MCJ, Asaro LA, Cheifetz IM, Wypij D, Curley MAQ; Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. Early Neuromuscular Blockade in Moderate-to-Severe Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2022 May 1;50(5):e445-e457. doi:10.1097/CCM.0000000000005426. Epub 2022 Jan 6. PMID:35029869.

Mattes MD, Sauers-Ford HS, Selleck D, Slee C, Natale JE, Rosenthal JL. Improving Pediatric Resident Safety Event Reporting Using Quality Improvement Methods. Hosp Pediatr. 2021 Mar;11(3):254-262. doi:10.1542/hpeds.2020-001081. PMID:33632748.

Natale JE, Lebet R, Joseph JG, Ulysse C, Ascenzi J, Wypij D, Curley MAQ; Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) Study Investigators. Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial. J Pediatr. 2017 May;184:204-208.e1. doi:10.1016/j.jpeds.2017.02.006. Epub 2017 Mar 2. PMID:28410087.

Natale JE, Joseph JG, Rogers AJ, Tunik M, Monroe D, Kerrey B, Bonsu BK, Cook LJ, Page K, Adelgais K, Quayle K, Kuppermann N, Holmes JF. Relationship of Physician-identified Patient Race and Ethnicity to Use of Computed Tomography in Pediatric Blunt Torso Trauma. Acad Emerg Med. 2016 May;23(5):584-90. doi:10.1111/acem.12943. Epub 2016 Apr 18. PMID:26914184.

Natale JE, Joseph JG, Rogers AJ, Mahajan P, Cooper A, Wisner DH, Miskin ML, Hoyle JD Jr, Atabaki SM, Dayan PS, Holmes JF, Kuppermann N; PECARN (Pediatric Emergency Care Applied Research Network). Cranial computed tomography use among children with minor blunt head trauma: association with race/ethnicity. Arch Pediatr Adolesc Med. 2012 Aug;166(8):732-7. doi:10.1001/archpediatrics.2012.307. Erratum in: Arch Pediatr Adolesc Med. 2014 Jun;168(6):586. PMID:22869404.

Natale JE, Asaro LA, Joseph JG, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley MAQ; RESTORE Study Investigators. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Ann Am Thorac Soc. 2021 Jan;18(1):93-102. doi:10.1513/AnnalsATS.201912-872OC. PMID:32776853.

Natale JE, Boehmer J, Blumberg DA, Dimitriades C, Hirose S, Kair LR, Kirk JD, Mateev SN, McKnight H, Plant J, Tzimenatos LS, Wiedeman JT, Witkowski J, Underwood MA, Lakshminrusimha S. Interprofessional/interdisciplinary teamwork during the early COVID-19 pandemic: experience from a children's hospital within an academic health center. J Interprof Care. 2020 Sep-Oct;34(5):682-686. doi:10.1080/13561820.2020.1791809. Epub 2020 Jul 16. PMID:32674638.