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Yang K. Xiang, Ph.D.
Professor
Yang K. Xiang is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Locations and Contact
Genome and Biomedical Sciences Building
Genome & Biomedical Sciences Facility
451 Health Sciences Drive
Davis, CA 95616
Phone: 530-752-3200
Additional Numbers
Phone
Research/Academic Interests
My current research focuses on aging/stress-related metabolic and inflammatory disorders and diseases like type 2 diabetes, diabetic cardiomyopathy, heart failure, and Alzheimer’s disease. We have recently characterized a novel insulin receptor and beta-adrenoceptor network expressed in different tissues. This opens a new field to understand insulin resistance in glucose metabolism and a broad range of cardiovascular and neuronal complications. We drew recent funding from NIH and VA to support these research directions. One of the major goals is to understand the prevalent co-existence of insulin resistance and adrenergic dysregulation in various diseases. We utilize a wide range of tools from single molecular analysis of receptor complex high resolution of living cell imaging to in vivo genetic, surgical, and pharmacological manipulation. By combining novel analytical tools with in vivo and in vitro characterization of receptor signaling and function, my laboratory has developed an integrative approach to systematically analyze insulin and adrenergic signaling in the brain and peripheral tissues. Eventually, we hope to provide information/strategies on clinical therapies for different metabolic and cardiovascular conditions.
Division
Pharmacology
Undergraduate School
B.S., Cell Biology, Wuhan University, Wuhan, China 1990
Other School
Ph.D., Cell Biology, Oregon Health and Science University, Portland OR 2000
American Heart Association Established Investigator, 2016
Wang Y, Shi Q, Li M, Zhao M, Reddy Gopireddy R, Teoh JP, Xu B, Zhu C, Ireton KE, Srinivasan S, Chen S, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2021 Jan 22;128(2):246-261. doi:10.1161/CIRCRESAHA.120.317452. Epub 2020 Nov 13. PMID:33183171.
Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 Aug 28;127(6):796-810. doi:10.1161/CIRCRESAHA.119.316319. Epub 2020 Jun 8. PMID:32507058.
Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons. Elife. 2019 Oct 14;8:e49464. doi:10.7554/eLife.49464. PMID:31609201.
Shen A, Nieves-Cintron M, Deng Y, Shi Q, Chowdhury D, Qi J, Hell JW, Navedo MF, Xiang YK. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nat Commun. 2018 Mar 13;9(1):1050. doi:10.1038/s41467-018-03459-7. PMID:29535304.
Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 3;135(1):73-88. doi:10.1161/CIRCULATIONAHA.116.022281. Epub 2016 Nov 4. PMID:27815373.
Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circ Res. 2016 Sep 30;119(8):931-43. doi:10.1161/CIRCRESAHA.116.308964. Epub 2016 Aug 30. PMID:27576469.
Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 2014 Aug;63(8):2676-89. doi: 10.2337/db13-1763. Epub 2014 Mar 27. PMID: 24677713; PMCID: PMC4113065.
Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6578-83. doi:10.1073/pnas.1117862109. Epub 2012 Apr 9. PMID:22493261.
Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T. Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26;473(7348):484-8. doi:10.1038/nature10016. PMID:21614075.
Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. FASEB J. 2010 Sep;24(9):3511-21. doi:10.1096/fj.10-156661. Epub 2010 Apr 15. PMID:20395454.