Michelle Apperson, M.D., Ph.D.

Michelle L. Apperson, M.D., Ph.D.






  • Director, UC Davis Multiple Sclerosis Program
  • Associate Clinical Professor


To see if Michelle L. Apperson is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis Midtown Ambulatory Care Center

3160 Folsom Blvd, Suite 2100
Sacramento, CA 95816
Driving Directions

Primary Phone:

Additional Phone Numbers

Fax: 916-451-2010
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Clinical Interests

Dr. Apperson's clinical interests include: General Neurology, Multiple Sclerosis, and Neuromyelitis Optica.

Research/Academic Interests

Dr. Apperson's research interests include clinical trials of novel multiple sclerosis treatments and identification of multiple sclerosis biomarkers.

Dr. Apperson is conducting genetic, genomic and other biochemical blood profiling to further elucidate the relationship between genetics and environmental factors in the autoimmune etiology of multiple sclerosis.




M.D., University of Hawaii, John A. Burns School of Medicine, Manoa HI 2001

Ph.D., Philosophy, California Institute of Technology, Pasadena CA 1996

B.A., UC San Diego, San Diego CA 1988

Internship: Internal Medicine, University of Hawaii at Manoa, Honolulu HI 2001-2002


Neurology, UC Davis Medical Center, Sacramento CA 2002-2005


Neurology/Multiple Sclerosis, UC Davis Medical Center, Sacramento CA 2005-2008

Board Certifications

American Board of Psychiatry and Neurology, 2007

Professional Memberships

American Academy of Neurology

American Medical Association

American Neurological Association

Society for Neuroscience

Honors and Awards

UC Davis Neurology Senior Resident Appreciation Award 2010, 2015

Sylvia Lawry Physician Fellow of the National Multiple Sclerosis Society, 2006-2008,

Chief Residency at UC Davis Neurology Residency Program, 2004

Select Recent Publications

Parish MB, Apperson M, Yellowlees PM. Engaging U.S. veterans with PTSD in online therapy. Psychiatr. Serv. 2014 May 1; 65(5):697.

Apperson ML, Tian Y, Stamova B, Ander BP, Jickling GC, Agius MA, Sharp FR. Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study. J. Neuroimmunol. 2013 Apr 15(1-2):90-6.

Dias RA, Hardin KA, Rose H, Agius MA, Apperson ML, and Brass SD. Sleepiness, fatigue, and risk of obstructive sleep apnea using the STOP-BANG questionnaire in multiple sclerosis: a pilot study. Sleep Breath, 2012 Dec; 16(4):1255-65.

Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Vigiletta V, Dawson KT; CONFIRM Study Infestiagors. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012 Sep 20; 367(12):1087-97.

Magley J, Towner D, Tache V, Apperson ML. Pregnancy outcome in anti-N-methyl-D-aspartate receptor encephalitis. Obstet Gynecol. 2012 Aug; 120:480-3.

Goldenholz DM, Wong VS, Bateman LM, Apperson M, Oskarsson B, Akhtar S and Wheelock V. Treatment of γ-Aminobutyric Acid B Receptor-Antibody Autoimmune Encephalitis With Oral Corticosteroids. Arch Neurol. 2012 Aug;69(8):1061-3.

Apperson ML and Agius MA. Clinical and neuroimaging assessments for research studies (including drug trials) in multiple sclerosis. Curr Protoc Neurosci. 2011 Jan; Chapter 10:Unit 10.4.

Tian Y, Apperson ML, Ander BP, Liu D, Stomova BS, Jickling GC, Enriquez R, Agius MA, and Sharp FR. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J. Neuroimmunol. 2011 Jan;230(1-2):124-9.

Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczyk P, Zhan X, Liu DZ, Anger BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, and Sharp FR. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Med Genomics. 2009 Jul;80(7):812-4.

Zhang L, Coffey S, Lua LL, Greco CM, Schafer JA, Brunberg J, Borodyaskaya M, Agius MA, Apperson M, Leehey M, Tartaglia N, Tassone F, Hagerman PJ, Hagerman RJ. FMR1 premutation in females diagnosed with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):812-4.