Nathan Kuppermann, M.D., M.P.H.
- Distinguished Professor, Departments of Emergency Medicine and Pediatrics
- Bo Tomas Brofeldt Endowed Chair, Department of Emergency Medicine, University of California, Davis School of Medicine
Dr. Kuppermann is a Distinguished Professor of Emergency Medicine and Pediatrics, and the Bo Tomas Brofeldt Endowed Chair of the Department of Emergency Medicine at UC Davis. He is a pediatric emergency medicine (PEM) physician and clinical epidemiologist, and a leader in emergency medical services for children, particularly in multicenter research. Research foci for which he is a leading national investigator include 1) infectious emergencies in children including the laboratory evaluation of young febrile children, 2) theevaluation of children at risk of diabetic ketoacidosis-related cerebral injury, and 3) the laboratory and radiographic evaluation of the pediatric trauma patient. His focus is on clinical trials and clinical prediction rules using large cohorts of acutely ill and injured children. He has published works in all three focus areas in high-impact journals such as the New England Journal of Medicine, JAMA, BMJ, and the Lancet. Dr. Kuppermann has received more than $30 million in federal grants and contracts as a PI over the past decade, and has published 275 peer-reviewed publications (Hirsch Index 69). Dr. Kuppermann has been a leader in multicenter research in PEM, starting by chairing the first U.S. research network in PEM (the Pediatric Emergency Medicine Collaborative Research Committee of the AAP) from 1996-2000, and leading several investigations there. He then became one of the founding investigators and founding Chair of the Steering Committee of the Pediatric Emergency Care Applied Research Network (PECARN) since it’s inception in 2001 until late in 2008, and remains one of the 7 network PIs. He recently completed a 4-year term as Chair of the Executive Committee of the (global) Pediatric Emergency Research Network (PERN), an international consortium of PEM research networks. He has mentored scores of trainees and junior faculty members, most of whom have gone on to academic careers, many of whom have secured federally-funded grants.
Dr. Kuppermann has been recognized nationally for his research and mentorship. In 2009, Dr. Kuppermann received the Miller-Sarkin Mentoring Award from the Academic Pediatric Association, and in 2012 received the Jim Seidel Distinguished Service Award, from the Section on Emergency Medicine of the AAP for outstanding contributions to Pediatric Emergency Medicine. In 2010 and 2011, he received national research awards from the EMSC program of HRSA, the Society for Academic Emergency Medicine (SAEM), and the American College of Emergency Physicians. In 2015, he was recognized with the American College of American Physicians EBSCO/PEMSoft Achievement Award for outstanding contributions to pediatric emergency evidence-based medicine. In 2017 a PEM Scientific Research Mentoring award was named after him by the SAEM, and in 2020 he was awarded the Hibbard Williams Extraordinary Achievement Award from UC Davis Health as well as the UC Davis Faculty Distinguished Research Award from the Academic Senate, UC Davis. In 2003 he was a Fulbright Distinguished Scholar in the U.K. and in 2010 he was elected to the National Academy of Medicine. In 2022 he was the recipient of the Maureen Andrew Mentor Award from the Society for Pediatric Research.
Dr. Kuppermann’s research foci include laboratory and radiographic evaluation of pediatric trauma patients; pediatric diabetic ketoacidosis-associated cerebral edema; clinical and laboratory evaluation of febrile children; and knowledge translation, shared decision-making and cost-effectiveness of clinical prediction rules.
Pediatric Emergency Medicine
M.D., UC San Francisco School of Medicine, San Francisco CA 1985
M.P.H., Harvard University School of Public Health, Boston MA 1993
B.Sc., Stanford University, Palo Alto CA 1981
Chief Resident-Department of Pediatrics, Harbor-UCLA Medical Center, Torrance CA 1989-1990
Pediatrics, Harbor-UCLA Medical Center, Torrance CA 1985-1989
Pediatric Emergency Medicine, Children�s Hospital Boston, Boston MA 1990-1993
American Board of Pediatrics, Diplomate,
American Board of Pediatrics, Pediatric Emergency Medicine - Diplomate, 2008
National Board of Medical Examiners, Diplomate,
Ambulatory Pediatric Association
American Academy of Pediatrics- Fellow
American Association for the Advancement of Science
American College of Emergency Physicians, Fellow
American Pediatric Society
Association of Academic Chairs of Emergency Medicine
National Academy of Medicine (NAM)
Pediatric Trauma Society
Society for Academic Emergency Medicine
Society for Pediatric Research
Honors and Awards
SAEM Pediatric Emergency Medicine Best Abstract Award: Newgard C, Lin A, Olson L, Cook J, Gausche-Hill M, Kuppermann N, Goldhaber-Fiebert J, Malveau S, Smith M, Dai M, Nathens A, Glass N, Jenkins P, McConnell J, Remick K, Hewes H, Mann C. A National Evaluation of Emergency Department Readiness and Outcomes Among US Trauma Centers. SAEM Annual Meeting (virtual)., 2020
SAEM Peter Rosen, MD Memorial Keynote Speaker (rescheduled to 2021 for COVID), 2020
American Registry Most Honored Doctors, 2020
Chancellor�s Departmental Award for Diversity and Community, UC Davis, 2020
Platinum Award for Institutional Global Learning, Research and Engagement (UC Davis Institutional award from the Association of Public and Land-Grant Universities), 2020
(Co-) Mentor for Dr. Austin Johnson, Winner of 2020 SAEM Junior Investigator Award, 2020
Hibbard Williams Extraordinary Achievement Award, UC Davis School of Medicine, 2020
Academic Senate Faculty Distinguished Research Award, UC Davis, 2020
SAEM Pediatric Emergency Medicine Top 5 Abstract Award: Mahajan PV, Tzimenatos L, Cruz A, Vitale M, Powell EC, Leetch AN, Pickett M, Richards R, VanBuren JM, Ramilo O, Kuppermann N, and PECARN. Prevalence of Bacteremia and Meningitis in Febrile Infants ? 60 Days with Positive Urinalyses. SAEM Annual Meeting (virtual)., 2020
SAEM Pediatric Emergency Medicine Top 5 Abstract Award: Kuppermann N, Dayan PS, VanBuren JM, Casper TC, Ramilo O, Mahajan PV, and PECARN. Validation of a Prediction Rule for Febrile Infants ? 60 Days in a Multicenter Network. SAEM Annual Meeting (virtual)., 2020
SAEM Pediatric Emergency Medicine Top 5 Abstract Award: Myers SR, Glaser NS, Trainor JL, Nigrovic LE, Garro A, Tzimenatos L, Quayle KS, Kwok MY, Rewers A, Stoner MJ, Schunk JE, McManemy JK, Brown KM, DePiero AD, Olsen CS, Casper TC, Ghetti S, Kuppermann N, and PECARN. Frequency, Risk Factors, and Associations of Acute Kidney Injury in Pediatric Diabetic Ketoacidosis. SAEM Annual Meeting (virtual)., 2020
SAEM Top 100 Abstracts (of > 800) Award: Singh S, Hearps SJ, Nishijima DK, Borland ML, Holmes JF, Dalziel S, Kuppermann N, Babl FE, and Hoch JS. The Cost-Effectiveness of Emergency Department Observation on Cranial CT Rates in Children with Minor Head Trauma. SAEM Annual Meeting (virtual)., 2020
SAEM Top 100 Abstracts (of > 800) Award: Heidt R, Kuppermann N, and Tancredi DJ. Isolated Altered Mental Status and Traumatic Brain Injury in Children with Minor Blunt Head Trauma. SAEM Annual Meeting (virtual)., 2020
PAS Presidential Plenary Abstract: Kuppermann N, Dayan PS, VanBuren JM, Casper TC, Ramilo O, Mahajan PV, and Pediatric Emergency Care Applied Research Network (PECARN). Validation of a Prediction Rule for Febrile Infants ? 60 Days in a Multicenter Network. Accepted at the PAS Annual Meeting (virtual)., 2020
Best Pediatric Residency Research Project UC Davis Health: Heidt R, Kuppermann N, and Tancredi DJ. Isolated Altered Mental Status and Traumatic Brain Injury in Children with Minor Blunt Head Trauma. Pediatric Resident Research Day (virtual)., 2020
American Academy of Pediatrics (AAP) Best Research Award: Kuppermann N, Dayan PS, VanBuren JM, Casper TC, Ramilo O, Mahajan PV, and PECARN. Validation of a Prediction Rule for Febrile Infants ? 60 Days in a Multicenter Network. AAP Annual Meeting (virtual)., 2020
SAEM Best Pediatric Emergency Medicine Abstract Award: Kuppermann N, Dayan PS, Vitale et al, and PECARN. Respiratory Viral Detection Does Not Alter the Performance of the PECARN Prediction Rule For Serious Bacterial Infections in Febrile Infants ? 60 Days Old. Acad Emerg Med 2021; 28:S44. Presented at the Society for Academic Emergency Medicine (SAEM) Annual Meeting (virtual)., 2021
SAEM Top 100 Abstracts (of > 800) Award: Singh S, Hoch J, Hearps S, Dalziel K, Cheek J, Holmes JF, Anderson V, Babl F, Kuppermann N for the Pediatric Research in Emergency Departments International Collaborative (PREDICT). Acute Care Costs of Pediatric Sports-related Head Injuries in Australia. Acad Emerg Med 2021; 28:S65. Presented at the SAEM National Meeting, May 2021 (virtual)., 2021
Selected for the Society for Pediatric Research Presidential Plenary: Funk A, Florin TA, Dalziel SR, Mintegui S, Salvadori MI, Tancredi D, Neuman MI, Payne DC, Plint AC, Klassen TP, Malley R, Ambroggio L, Kim K, Simons NJ, Kuppermann N, Freedman SB, on behalf of the PERN-COVID-19 study team. Clinical Outcomes of Children with SARS-CoV-2 Presenting to Pediatric Emergency Departments: Interim Analysis of a Global COVID-19 Cohort Study. Presented at the Pediatric Academic Societies Meeting, May 2021 (virtual)., 2021
American Registry Most Honored Doctors, 2021
Select Recent Publications
Abid Z, Kuppermann N, Tancredi DJ, Dayan P. Risk of Traumatic Brain Injury in Infants Younger than 3 Months with Minor Blunt Head Trauma. Ann Emerg Med. 2021. Epub ahead of print. PMID:34148662.
Rewers A, Kuppermann N, Ghetti S, Schunk J, Stoner M, Rewers A, McManemy J, Myers S, Ligrovic L, Garro A, Brown K, Quayle K, Trainor J, Bennett J, DePiero A, Tzimenatos L, Kwok M, Perry C, Dean JM, Olsen CS, Glaser N, for the Pediatric Emergency Care Applied Research Network (PECARN). Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children with Diabetic Ketoacidosis. Diabetes Care. 2021. Epub ahead of print. PMID:34187840.
Greenberg JK, Ahluwalia R, Hill M, Johnson G, Hale AT, Belal A, Baygani S, Olsen MA, Foraker RE, Carpenter CR, Yan Y, Ackerman L, Noje C, Jackson E, Burns E, Sayama CM, Selden NR, Vachhrajani S, Shannon CN, Kuppermann N, Limbrick DD Jr. Development and External Validation of the KIIDS-TBI Tool for Managing Children with Mild Traumatic Brain Injury. Acad Emerg Med. 2021. Epub ahead of print. PMID:34245632.
Linakis SW, Kuppermann N, Stanley RM, Hewes H, Myers S, VanBuren JM, Charles Casper T, Bobinski M, Ghetti S, Schalick WO 3rd, Nishijima DK; TIC-TOC Collaborators of the Pediatric Emergency Care Applied Research Network (PECARN). Enrollment with and without Exception form Informed Consent in a Pilot Trial of Tranexamic Acid in Children with Hemorrhagic Injuries. Acad Emerg Med. 2021. Epub ahead of print. PMID:34250690.
Pantell RH, Roberts KB, Adams WG, Dreyer BP, Kuppermann N, O'Leary ST, Okechukwu K, Woods CR Jr; SUBCOMMITTEE ON FEBRILE INFANTS. Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old. Pediatrics 2021;148(2):e2021052228. PMID:34281996.
Neumar RW, Blomkalns AL, Cairns CB, D'Onofrio G, Kuppermann N, Lewis RJ, Newgard CD, O'Neil BJ, Rathlev NK, Rothman RE, Wright DW. Emergency Medicine Research: 2030 Strategic Goals. Acad Emerg Med 2021, Epub ahead of print. PMID:34363718.
Shan J, Warton EM, Reed ME, Vinson DR, Kuppermann N, Dayan PS, Dalziel SR, Rauchwerger AS, Ballard DW. Computed Tomography Use in Children with Minor Head Trauma Presenting to 21 Community Emergency Departments within an Integrated Health Care System. Perm J. 2021. in press.
* Glaser N, Stoner M, Garro A, Baird S, Myers S, Rewers A, Trainor J, Quayle K, McManemy J, DePiero A, Nigrovic L, Tzimenatos L, Schunk J, Olsen CS, Casper TC, Ghetti S, Kuppermann N, for the Pediatric Emergency Care Applied Research Network (PECARN). Serum Sodium Concentration and Mental Status in Children with Diabetic Ketoacidosis. Pediatrics. 2021. in press. PMID:34373322.
* Schunk J, Jacobsen K, Stephen D, Watson A, Olsen CS, Casper TC, Glaser N, Kuppermann N, for the Pediatric Emergency Care Applied Research Network (PECARN). Enroller Experience and Parental Familiatrity of Disease Influence Participation in a Pediatric Trial. West J Emerg Med. 2021. in press.
Mayer SA, Frontera JA, Jankowitz B, Kellner CP, Kuppermann N, Naik BI, Nishijima DK, Steiner T, Goldstein JN. Recommended Primary Outcomes for Clinical Trials Evaluating Hemostatic Agents in Patients with Intracranial Hemorrhage. JAMA Netw Open. 2021. in press.
Dr. Nate Kuppermann discusses H1N1 pandemic risk factors for children