Daisuke Sato, Ph.D.

Daisuke Sato, Ph.D.

Specialties

Biomedical Engineering

Department

Pharmacology

Title

  • Associate Professor

Reviews

Research/Academic Interests

Sudden cardiac death is the leading cause of death in the United States. Our knowledge of sudden cardiac death is still limited. CAST (Cardiac Arrhythmia Suppression Trial) and SWORD (Survival With Oral d-Sotalol) clinical trials failed and tested drugs increased mortality. These single target drugs often cause unpredicted phenomena in the heart, which is the highly complex system. The complexities come from nonlinearities in the heart. The goal of Dr. Sato's research is to understand how molecular level properties are linked to organ level phenomena using mathematical analysis and multiscale modeling of the heart.

The goal of Dr. Sato's research is to understand how molecular level properties are linked to organ level phenomena using mathematical analysis and multiscale modeling of the heart.

Division

Pharmacology

Education

Ph.D., Physics, Northeastern University, Boston MA 2006

B.S., Waseda University, Tokyo, Japan 1999

Select Recent Publications

To view Dr. Sato's publications, please click here.

Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. A stochastic model of ion channel cluster formation in the plasma membrane. J Gen Physiol. 2019 Sep 2;151(9):1116-1134. doi:10.1085/jgp.201912327. Epub 2019 Aug 1. PMID:31371391.

Xie Y, Yang Y, Galice S, Bers DM, Sato D. Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves. Biophys J. 2019 Feb 5;116(3):530-539. doi:10.1016/j.bpj.2018.12.017. Epub 2019 Jan 3. PMID:30686487.

Galice S, Xie Y, Yang Y, Sato D, Bers DM. Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release. J Am Heart Assoc. 2018 Jun 21;7(13):e008724. doi:10.1161/JAHA.118.008724. PMID:29929992.

Sato D, Dixon RE, Santana LF, Navedo MF. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics. PLoS Comput Biol. 2018 Jan 16;14(1):e1005906. doi:10.1371/journal.pcbi.1005906. PMID:29338006.

Sato D, Clancy CE, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 2017 Sep 6;3(9):e00388. doi:10.1016/j.heliyon.2017.e00388. PMID:28924617.

Kennedy M, Bers DM, Chiamvimonvat N, Sato D. Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans. J Physiol. 2017 Apr 1;595(7):2285-2297. doi:10.1113/JP273626. Epub 2017 Jan 24. PMID:27902841.

Galice S, Bers DM, Sato D. Stretch-Activated Current Can Promote or Suppress Cardiac Alternans Depending on Voltage-Calcium Interaction. Biophys J. 2016 Jun 21;110(12):2671-2677. doi:10.1016/j.bpj.2016.05.026. PMID:27332125.

Sato D, Shannon TR, Bers DM. Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks. Biophys J. 2016 Jan 19;110(2):382-390. doi:10.1016/j.bpj.2015.12.009. PMID:26789761.

Sato D, Bartos DC, Ginsburg KS, Bers DM. Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue. Biophys J. 2014 Sep 16;107(6):1313-7. doi:10.1016/j.bpj.2014.07.053. PMID:25229139.