Stefano Morotti, Ph.D.

Stefano Morotti, Ph.D.

Specialties

Pharmacology

Physiology

Department

Pharmacology

Title

  • Assistant Professor, Department of Pharmacology

Reviews

Genome and Biomedical Sciences Building

451 Health Sciences Drive, Suite 3503
Davis, CA 95616
Driving Directions

Primary Phone:
530-752-3200

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Dr. Morotti's research focuses on the regulation of muscle cells (myocytes) in the cardiovascular system. His overall goal is to identify therapeutic targets, inform treatment strategies, and predict the outcome of pharmacological treatment. To pursue this aim, Dr. Morotti develops biophysically-detailed mathematical models of cardiac and vascular myocyte electrophysiology, ion transport, and signaling, and uses them to quantitatively investigate the cellular mechanisms regulating excitation-contraction coupling in healthy condition and disease.

Division

Pharmacology

Education

M.S., University of Bologna, Italy 2009

Ph.D., Bioengineering, University of Bologna, Italy 2013

B.S., University of Bologna, Italy 2006

Honors and Awards

Travel Award, UC Davis Academic Federation, 2019

People�s Choice Award, National Institutes of Health SPARC DRC Hackathon, Bethesda MD (USA), December 5-7, 2018

Nomination, UC Davis Award for Excellence in Postdoctoral Research, 2017

Early Career Investigator Travel Award, 35th International Society for Heart Research � North American Section Meeting, Seattle, WA (USA), June 7-10, 2015

Select Recent Publications

To view Dr. Morotti's publications, please click here: https://www.ncbi.nlm.nih.gov/myncbi/1hu1_97i87j5o/bibliography/public/

Ljubojevic-Holzer S, Herren AW, Djalinac N, Voglhuber J, Morotti S, M. Holzer, Wood BM, Matzer I, Sacherer M, Radulovic S, Abdellatif M, Wallner M, Ivanov M, Wagner S, Sossalla S, Von Levinski D, B. Pieske B, Brown JH, Sedej S, Bossuyt J, Bers DM. Activation and nuclear accumulation of CaMKIIδC is a pivotal early regulator of eccentric cardiac hypertrophy. Circ Res. In press.

Ni H, Fogli Iseppe A, Giles W, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocyte and tissues reveal synergy of multi-atrial-predominant K+ current block in atrial fibrillation. Br J Pharmacol. 2020 Oct;177(19):4497-4515. Epub 2020 Jul 15. doi:10.1111/bph.15198. 

Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne E, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintrón M, Xiang YK. GRK5 controls SAP97-dependent cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure. Circ Res. 2020 Aug 28;127(6):796-810. doi:10.1161/CIRCRESAHA.119.316319. Epub 2020 Jun 8.

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogested J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE. Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circ Res. 2020 Mar 27;126(7):889-906. doi:10.1161/CIRCRESAHA.119.315641. Epub 2020 Feb 19. PMID:32070187.

Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Tshinanu FM, Strauss DG. General Principles for the Validation of Proarrhythmia Risk Prediction Models: an Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 Jan;107(1):102–111. doi:10.1002/cpt.1647. Epub 2019 Nov 10. PMID:31709525.

Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 Sep;597(17):4533-4564. doi:10.1113/JP277724. Epub 2019 Jul 27. PMID:31278749.

Wang L, Morotti S, Tapa S, Stuart SDF , Jiang Y, Wang Z, Myles RC, Brack KE, Ng GA, Bers DM, Grandi E, Ripplinger CM. Different paths, same destination: Divergent electrophysiological responses result in conserved cardiac fight-or-flight response in mouse and rabbit hearts. J Physiol. 2019 Aug;597(15):3867-3883. doi:10.1113/JP278016. Epub 2019 Jul 11. PMID:31215643.

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW, Santana LF, Xiang YK, Nieves-Cintrón M, Navedo MF. Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest. 2019 Jun 4;129(8):3140-3152. doi:10.1172/JCI124705. PMID:31162142.

Hegyi B, Morotti S, Liu C, Bányász T, Ginsburg KS, Bossuyt J, Belardinelli L, Izu LT, Chen-Izu Y, Grandi E, Bers DM. Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-dependent and β?Adrenergic Effects on Late Sodium, L-type Calcium and Sodium-Calcium Exchange Currents. Circ Arrhythm Electrophysiol. 2019 Mar;12(3):e007061. doi:10.1161/CIRCEP.118.007061. PMID:30879336.

Ni H, Morotti S, Grandi E. A heart for diversity: simulating variability in cardiac arrhythmia research. Front Physiol. 2018 Jul 20;9:958. doi:10.3389/fphys.2018.00958. eCollection 2018. PMID:30079031.