When a patient loses 90 to 95 percent of his or her kidney function, they are considered to have End Stage Renal Disease (ESRD). At this point, life-saving treatment becomes necessary. Treatment options for patients with ESRD are dialysis (where an artificial kidney machine removes waste from the blood) or a kidney transplant from a living or deceased donor.
Sometimes, a patient with 85 percent loss of kidney function will undergo a transplant which allows them to avoid having to go on dialysis. Kidney patients and their families will discuss the best course of treatment with their doctors

Donors need to be at least 18 years of age and can include parents, children, siblings, other relatives, and friends. A donor should have a genuine interest in donating and must have a compatible blood type with the recipient.  When donors are not compatible with their intended recipient, the option of paired exchange donation can happen as well.
Donors should be in good general health. Typically, someone who has high blood pressure (both treated and untreated), cancer, diabetes, kidney disease, heart disease, liver disease, sickle cell disease, clotting disorders, HIV or active hepatitis will not qualify to be a donor. However, some diseases are not absolute contraindications to donation. Every donor will be considered on an individual basis.

The decision to donate can vary from person to person. Some people make the decision instantly with few worries or concerns. Other people go through some soul-searching and will talk with close friends or family before deciding whether or not to donate. It is normal for some people to be afraid of donating a kidney as well as to experience guilt about not wanting to be a donor.
Individuals should not, under any circumstances, feel pressured to donate. The only “right” decision is the one that makes the donor feel comfortable. Potential donors are encouraged to speak with the living donor team if they have any questions or concerns about their decision.

If you are interested in being a living donor, you should click on the link to the health questionnaire. Once the questionnaire has been fully completed it will be reviewed by a nurse coordinator to determine if you may proceed with initial blood testing.
Once your blood type and preliminary blood and uring testing are known, the living donor nurse coordinator will discuss the results and the donation process with you and answer any questions so that you can make an informed decision about proceeding with donation. This conversation is strictly confidential and is not shared with the recipient. If the donor decides to continue with donation, they must then complete a comprehensive evaluation.

We encourage all donor evaluations to be completed at the University of California Davis Medical Center, Sacramento CA. The work-up can often be completed in 1-2 days, though additional testing may be required in some cases.

You will complete a medical history and receive a physical, which includes a blood pressure check, to ensure that you don’t have any concerning health conditions.

A series of laboratory and X-ray tests, as well as an EKG, will be completed to screen for kidney function, liver function, hepatitis, heart disease, lung disease and past exposure to viral illness. Urine testing will also be done to make sure that your kidneys function normally. In addition, results from your routine annual health maintenance tests (e.g., pap smear, mammogram, colonoscopy, etc), as well as any necessary medical clearance for pre-existing conditions, will need to be submitted to the living donor team for review. Other tests may be necessary depending on the results of these studies.

A CT angiogram (a computerized tomography, or CTA) scan will also be completed. During this scan, contrast is injected into the blood stream through a vein in your arm. The contrast travels to the kidneys and urinary tract while the CTA scan and X-rays are done. These tests help the transplant staff to determine if your urinary tract, kidneys, and the blood vessels leading to the kidneys are normal. These procedures are done in the hospital on an outpatient basis. The scan takes about an hour and does not affect your ability to drive a car. The scan must be completed at the University of California Davis Medical Center to ensure quality of radiographic 3D construction of the kidney vessels. Again if you are from another state or out of the Sacramento area we will work with a transplant center near you to complete this study.

You will also meet with a nephrologist, dietician, and complete a psychosocial evaluation with a clinical social worker.

Once all results from the entire evaluation process are available, they will be reviewed by a multidisciplinary committee who decides whether you are able to safely proceed with the donation.

Your surgeon and nurse coordinator will discuss all health risks with you. The risks of donation are similar to those involved with any major surgery, such as bleeding and infection. Death resulting from kidney donation is extremely rare. Current research indicates that kidney donation does not change life expectancy or increase a person’s risks of developing kidney disease or other health problems.

A person can lead an active, normal life with only one kidney. Studies have shown that one kidney is sufficient to keep the body healthy. After recovering from surgery, a donor can work, drive, exercise and participate in sports, though contact sports are not recommended. A donor can continue in all types of occupations, including military duty. Also, being a donor does not impact a person’s ability to have a child.

A recent article that evaluated data on a donor’s ability to obtain life, disability, or health insurance after surgery found that the majority of donors surveyed did not experience any problems. However, the article indicated that a small percentage of donors reported some difficulty with their insurability. All donors are encouraged to check with their insurance companies to verify their policy.
*Source: Insurability of Living Organ Donors: A Systematic Review. R. C. Yang, et al. American Journal of Transplantation (2007) 7:6, 1542-1551.

The week before the transplant, both you and your recipient will come to the hospital for pre-admission testing. You will be provided with specific instructions on how to prepare the night before surgery. The same day, you will have more lab work completed and will also meet with your nurse coordinator and social worker to review what to expect during your stay in the hospital and at discharge. You will also meet with the surgeons to discuss the surgery in detail

You will be admitted to the hospital the morning of the surgery. Both you and your recipient go directly to the Same Day Surgery Suite at the Medical Center. Once there, the staff starts an intravenous (IV) line where fluids are administered. You will meet with your surgeon who will answer any remaining questions and will have you complete a consent form for the procedure.

Shortly after arriving in the operating room, the anesthesiologist will give you sedation medicine through the IV. Once you are fast asleep, a breathing tube for general anesthesia is placed which connects to a breathing machine. This routine process assists patients with breathing during surgery. A urinary catheter is inserted into the bladder and then the laparoscopic surgery begins.

During the surgery, a few very small incisions are made in the abdomen to insert laparoscopic instruments. The laparoscope contains a miniature camera that helps guide the surgical team. Once the kidney dissection is complete, a 3-4 inch incision is made to allow for the removal of the kidney. These incisions are closed using stitches that absorb on their own so they do not need to be removed.

You will wake up in the recovery room feeling groggy and perhaps uncomfortable. A nurse closely monitors your vital signs and comfort level. Pain medicine will be given as requested. You will be wearing an oxygen mask and have a catheter draining urine from the bladder to a collecting bag in order to accurate measure the kidney’s urine output. The catheter is usually left in overnight and removed at the bedside on the day you go home.

You are encouraged to get out of bed as soon as possible – usually the night of surgery. Walking is expected the next day. It is common for donors to experience gas pain and bloating after surgery. Walking will help to expel the gas.
You should be released from the hospital 1-2 days following the operation.

When you return home, your activities will be limited. You should not lift anything that weighs more that 15 lbs. for the first six weeks. You may feel tired for the first week or two after the surgery and may need frequent naps. However, donors are encouraged to be active in between their periods of rest. Walking is considered excellent exercise during this time. You may also have some swelling around the incision area and should plan to wear loose, comfortable clothes.
You will likely be able to return to work 4-6 weeks after the surgery, depending on the type of work. However some donors require a longer recovery period if their work requires heavy lifting or other physical demands.

You will have a post-operative appointment with your surgeon 1 week after the surgery.   At 6 months, 12 months, and 24 months after surgery, you will complete blood and urine tests.  Also, it is recommended that routine annual check-ups are completed with your primary care physician.

Most living donors say they feel great satisfaction with the donation experience because they have helped to improve another person’s quality of life. Even in rare instances where the transplant is not successful, many donors say they feel positive about their decision because they did their very best to help a relative or friend. However, there is a small chance for donors to experience some negative or mixed feelings after the donation. These feelings have been more likely to occur in cases where the outcome of the surgery did not meet the expectations of the donor and/or recipient as well as in cases where the donor was unsure of his or her decision.

Living donors are financially responsible for their routine annual health maintenance testing (e.g., pap smear, mammogram, colonoscopy, etc.) or medical clearance that may be required for pre-existing conditions. However, all other testing required for the living donor evaluation as well as the hospitalization costs and physician services provided during the donation process are covered by recipient’s insurance.

All non-medical expenses such as lost wages, child care, travel costs and daily living expenses that are incurred during the donation process are NOT covered. Therefore, it is important for donors to consider the financial impact of these possible expenses. Additional pain medication refills after discharge are also not covered and would need to be covered by the donor’s insurance or paid for.