Kristen Wigby, M.D. for UC Davis Health

Kristen Wigby, M.D.

Associate Professor of Clinical Pediatrics

To see if Kristen Wigby is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).



Genomic Medicine



Genomic Medicine, Pediatrics



Locations and Contact

UC Davis MIND Institute

UC Davis MIND Institute
2805 50th Street
Sacramento, CA 95817

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Philosophy of Care

I believe each family's rare disease journey is unique and I aim to partner with the family to develop a personalized care plan for their child.  I seek to educate about care options and empower families in their care choices.  

Clinical Interests

Dr. Wigby is a board-certified clinical geneticist and dysmorphologist offering care for children and their families with rare genetic conditions. She also provides consultation for children with a concern for a possible genetic condition including neurodiverse children, children with congenital anomalies, a family history of an inherited disorder, or other health conditions such as epilepsy or neuromuscular disorders.  

Dr. Wigby has special clinical interest and expertise in sex chromosome variations including Trisomy X and Turner syndrome, Smith-Magenis syndrome, and rare neurogenetic disorders.

Research/Academic Interests

Dr. Wigby’s research focuses on the delineation of rare genetic disorders presenting infancy and neurodevelopmental disorders.  From 2018-2023, Dr. Wigby was a clinical investigator with the Rady Children’s Institute for Genomic Medicine (RCIGM).  She brings expertise in the clinical implementation of genome sequencing across a variety of pediatric populations including children hospitalized in intensive care units, congenital anomalies, and neurodevelopmental disorders.  She also co-founded and was the medical director of the Rady Children’s Precision Medicine Clinic which leveraged genome sequencing, functional studies, and research collaborations for children with ultra-rare and undiagnosed neurogenetic disorders.  

In addition, Dr. Wigby also studies phenotypic diversity in females with Trisomy X and was a leader in developing the first guidelines for multidisciplinary care of females with Trisomy X. 


Genomic Medicine

Center/Program Affiliation

UC Davis Children's Hospital
UC Davis MIND Institute

Undergraduate School

B.S., Neuroscience, UCLA, 2006

Medical School

M.D., UCSD, 2012


Pediatrics, Universtiy of Colorado Denver/Children's Hospital of Colorado, 2012-13


Pediatrics, Universtiy of Colorado Denver/Children's Hospital of Colorado, 2013-15


Medical Genetics & Genomics, University of California, San Diego/ Rady Children's Hospital, 2015-18

Joyce Felder Service Award, University of California, San Diego, 2009

Induced Member, Arnold P. Gold Humanism Society, 2011

Department of Pediatrics Senior Award, University of California, San Diego, 2012

George G. Glenner Award, University of California, San Diego, 2012

Great Save Award, University of Colorado, Denver Pediatrics, 2013

Mead Johnson Trainee Travel Award, Western Society for Pediatric Research, 2017

Mead Johnson Junior Faculty Travel Award, Western Society for Pediatric Research, 2019

National Center for Leadership in Academic Medicine Faculty Development Program, Univeristy of California, San Diego, 2021

Mead Johnson Junior Faculty Travel Award, Western Society for Pediatric Research, 2022

Wigby K, D'Epagnier, C, Howell, S, Reicks A, Wilson, R, Cordeiro, L, Tartaglia, N. Expanding the Phenotype of Triple X Syndrome: A Comparison of Prenatal vs. Postnatal Diagnosis. Am J Med Genet A. 2016 Nov;170(11):2870-2881

Wigby K, Hammer M, Tokita M, Patel, P, Jones MC, Larson A, Velez Bartolomei F, Dykzeul N, Slavotinek, Yip T, Bandres-Ciga S, Simpson BN, Suhrie K, Shankar S, Veith R, Bragg J, Powell C, Kingsmore SF, Dimmock D, Maron J, Davis J, Del Campo M. Insights into the perinatal phenotype of infants with Kabuki syndrome identified by genome-wide sequencing. American J Med Genet Part A, 2023 Jan 18. doi: 10.1002/ajmg.a.63097. 


Scocchia A*, Wigby KM*, Masser-Frye D, Del Campo M, Galarreta CI, Thorpe E, McEachern J, Robinson K, Gross A; ICSL Interpretation and Reporting Team, Ajay SS, Rajan V, Perry DL, Belmont JW, Bentley DR, Jones MC, Taft RJ. Clinical whole genome sequencing as a first-tier test at a resource-limited dysmorphology clinic in Mexico. NPJ Genom Med. 2019 Feb 14;4:5

Maron JL, Kingsmore S, Gelb BD, Vockley J, Wigby K, Bragg J, Stroustrup A, Poindexter B, Suhrie K, Kim JH, Diacovo T, Powell CM, Trembath A, Guidugli L, Ellsworth KA, Reed D, Kurfiss A, Breeze JL, Trinquart L, Davis JM. Rapid Whole-Genomic Sequencing and a Targeted Neonatal Gene Panel in Infants With a Suspected Genetic Disorder. JAMA. 2023 Jul 11;330(2):161-169. doi: 10.1001/jama.2023.9350

Kingsmore SF, Cakici JA, Clark MM, Gaughran M, Feddock M, Batalov S, Bainbridge MN, Carroll JM, Caylor SA, Clarke C, Ding Y, Ellsworth K, Farnaes L, Hildreth A, Hobbs C, James K, Kint CI, Lenberg J, Nahas S, Prince L, Reyes I, Salz L, Sanford E, Schols P, Sweeney N, Tokita M, Veeraraghavan N, Watkins K, Wigby K, Wong T, Chowdhury S, Wright MS, Dimmock D. A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants. Am J Hum Genet. 2019 Oct, 105, 719-733

Dimmock D, Caylor S, Waldman B, Benson W, Ashburner C, Carmichael JL, Carroll J, Cham E, Chowdhury S, Cleary J, D'Harlingue A, Doshi A, Ellsworth K, Galarreta CI, Hobbs C, Houtchens K, Hunt J, Joe P, Joseph M, Kaplan RH, Kingsmore SF, Knight J, Kochhar A, Kronick RG, Limon J, Martin M, Rauen KA, Schwarz A, Shankar SP, Spicer R, Rojas MA, Vargas-Shiraishi O, Wigby K, Zadeh N, Farnaes L. Project Baby Bear: Rapid precision care incorporating rWGS in 5 California children's hospitals demonstrates improved clinical outcomes and reduced costs of care. Am J Hum Genet. 2021 Jul 1;108(7):1231-1238. doi: 10.1016/j.ajhg.2021.05.008.

NICUSeq Study Group, Krantz ID, Medne L, Weatherly JM, Wild KT, Biswas S, Devkota B, Hartman T, Brunelli L, Fishler KP, Abdul-Rahman O, Euteneuer JC, Hoover D, Dimmock D, Cleary J, Farnaes L, Knight J, Schwarz AJ, Vargas-Shiraishi OM, Wigby K, Zadeh N, Shinawi M, Wambach JA, Baldridge D, Cole FS, Wegner DJ, Urraca N, Holtrop S, Mostafavi R, Mroczkowski HJ, Pivnick EK, Ward JC, Talati A, Brown CW, Belmont JW, Ortega JL, Robinson KD, Brocklehurst WT, Perry DL, Ajay SS, Hagelstrom RT, Bennett M, Rajan V, Taft RJ. Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial. JAMA Pediatr. 2021 Sep 27:e213496. doi: 10.1001/jamapediatrics.2021.3496