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Da Zhi Liu, Ph.D.Professor Med Neuroscience Building |
Research Interests
During his early career, Da Zhi Liu, Ph.D. came up with a new concept “Aberrate Cell Cycle Disease (ACCD)”, revealing that tumor growth in cancers and neuronal death in neurological disorders share the common mechanism of “aberrant cell cycle re-entry”. Based on the ACCD concept, he established a program entitled “Leveraging Cancer Elements to Study Neurological Disorder and Mental Illness”. This research program has led to four patented products (e.g., tumor suppressor microRNAs, FDA-approved kinase inhibitors) for the treatment of acute brain injury and mental illness. In addition to academic pursuits, he founded a UCD-affiliated startup company "Mirnova Therapeutics” in the process of licensing the patented products from the UCD, with the mission to develop safe, effective and affordable drugs.
Education
University of California at Davis, Post-doc, Neuroscience, 2010
Shanghai Institute of Materia Medica, Ph.D., Shanghai, Neuro-Pharmacology, 2005
Tongji Medical School, Master, Wuhan, Cardio-Pharmacology, 2022
Anhui Traditional Medical College, Hefei, PharmD. 1998
Professional Memberships
Society for Cerebral Blood Flow and Metabolism
Curriculum Development and Teaching
University Honors Course (HNR 198, 3 Units)
Title: “The Cell Cycle and Disease”
First Year Seminar (FYS 001, I Unit; FYS 003 1 Unit)
Title: “Aberrant Cell Cycle- A Common Mechanism of Cancers and Neurological Disorders” Service
Service
DoD-TBIPHRP study panels (TR-DD, FP-TT, etc.)
Admission Committee (UC Davis SOM)
Research Activities and Funding
MicroRNA Therapeutics for Traumatic Brain Injury (R01NS114061) February 15, 2020 - January 31, 2025
Role of the Src in Traumatic Brain Injury (R01NS089901) May 15,2015 - February 28, 2020
Patents
Liu DZ. Methods for Treating Brain Injury. PCT/US19/019235 https://patents.google.com/patent/WO2019165267A1/en
Liu DZ, Lyeth B. Martin R, Shahlaie K. METHODS OF USINg DASATINIB to TREAT TRAUMATIC BRAIN INJURY. PCT/US2022/051052
Liu DZ, Lyeth B. Martin R, Shahlaie K. METHODS OF USINg Abemaciclib to TREAT TRAUMATIC BRAIN INJURY PCT/US2022/051931
Publications
Lui A, Do T, Alzayat O, Yu N, Phyu S, Santuya HJ, Liang B, Kailash V, Liu D, Inslicht SS, Shahlaie K, Liu D. Tumor Suppressor MicroRNAs in Clinical and Preclinical Trials for Neurological Disorders. Pharmaceuticals 2024 Mar 27; 17(4). PMCID: PMC11054060
Ameen SS, Griem-Krey N, Dufour A, Hossain MI, Hoque A, Sturgeon S, Nandurkar H, Draxler DF, Medcalf RL, Kamaruddin MA, Lucet IS, Leeming MG, Liu D, Dhillon A, Lim JP, Basheer F, Zhu HJ, Bokhari L, Roulston CL, Paradkar PN, Kleifeld O, Clarkson AN, Wellendorph P, Ciccotosto GD, Williamson NA, Ang CS, Cheng H C. N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection. Mol Cell Proteomics. 2023, 22: 100543. PMID: 37030595
Lui A, Alzayat O, Do T, Perekopskiy D, Gann M, Elgokhy TS, Gao J, Liu DZ. Multi-targeted anti-inflammatory drugs for the treatment of neurological disorders. Neural Regen Res. 2023 Apr;18(4):805-806. PMID: 36204844
Lui A, Vanleuven J, Perekopskiy D, Liu D, Xu D, Alzayat O, Elgokhy T, Do T, Gann M, Liu DZ. FDA-Approved Kinase Inhibitors in Preclinical and Clinical Trials for Neurological Disorders. Pharmaceuticals. 2022, 15: 1546. PMID: 36558997
Ye Z, Izadi A, Gurkoff GG, Rickerl K, Sharp FR, Ander BP, Bauer AZ, Lui A, Lyeth BG, Liu DZ. Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury. J Neurotrauma. 2022 Apr;39(7-8):520-529. PMID: 35109711
Lv B, Cheng XY, Sharp FR, Ander BP, Liu DZ. Broad therapeutic window of miR-122 mimic to improve stroke outcome through indirect inhibition of NOS2. Front. Neurosci. 2018;12:767. PMID: 30405345
Liu DZ. Repurposing cancer drugs to treat neurological diseases – Src inhibitors as examples. Neural Regen Res. 2017 Jun;12(6):910-911. PMID: 28761420
Liu DZ, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B, Sharp FR. Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2016;36(8):1374-83. PMID: 26661204
Liu DZ. Aberrant cell cycle re-entry: Links between Cancers and Alzheimer’s disease. JSM Alzheimer’s Disease and Related Dementia. 2014; 1(2):1006. Editorial
Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B, Liu D. microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted GeneTargets. PLos One. 2014;9(6):e99283. PMID: 24911610
Liu DZ, Sharp FR, Van KC, Ander BP, Ghiasvand R, Stamova B, Zhan X, Jickling GC, Lyeth BG. Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury. J Neurotrauma. 2014 Jul 15;31(14):1268-76. PMID: 24428562
Liu DZ. Mutations in Tumor Suppressor Genes: Links between Cancers and Autism Spectrum Disorders? Journal of Cytology & Histology. 2013; 5:e109. Editorial
Liu DZ, Ander BP, Cell Cycle Inhibition without Disruption of Neurogenesis is a Strategy for Treatment of Aberrant Cell Cycle Diseases: an Update. ScientificWorldJournal. 2012; 2012:491737. PMID: 22547985. Review
Liu DZ, Tian Y, Ander BP, Xu H, Stamova B, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage and kainate seizures. J Cereb Blood Flow Metab. 2010 Jan;30(1):92-101. PMID: 19724284
Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood brain barrier breakdown and repair after thrombin-induced brain injury. Ann Neurol. 2010;67(4):526-33. PMID: 20437588
Liu DZ, Cheng XY, Ander BP, Xu H, Davis RR, Gregg JP, Sharp FR. Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol. Dis. 2008 May;30(2):201-11. PMID: 18343677.
