The Guo lab focuses on glial cell biology to promote myelin formation and regeneration in white matter injury and diseases, using genetic, molecular, and animal models to explore potential therapeutic interventions.
The Guo Lab
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Principal InvestigatorFuzheng Guo, Ph.D.
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Our Research Goals
Our long-term research goal is to devise novel therapeutic interventions for promoting myelin formation (myelination) and myelin regeneration (remyelination) in white matter injury or diseases.
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Current Projects
1) Astrocyte homeostasis and its function in CNS demyelination (NIH 1R01NS134887)
2) Protein PARylation and its function in myelination, demyelination, and remyelination (NIH R01NS123165)
3) Hypoxia inducible factors and neonatal white matter injury (NIH R21 NS109790 , NIH R01NS123080)
4) Role of P21-activated kinase 1 (PAK1) in CNS myelination, demyelination, and remyelination (NIH R21NS125464)
5) Wnt effector TCF7l2 in CNS myelin formation and repair (NIN R01NS094559)
6) Serpina3n/SERPINA3 regulation of CNS neuropathology -
Our Team
• Meina Zhu, M.D., Ph.D.
• Joohyun Park, Ph.D.
• Huimin Chen, Ph.D.
• Hyun Kyu Kim, Ph.D.
• Bhabotosh Barman, Ph.D.
• Annlin Titus
• Rohini Murali
• Evelyn Wong
• Audrey Park
• Jane Joseph
• Qihan (Kevin) Wang
• Nathan Wang
• Varun Natarajan
• Chengda Guo, PhD
Clinical Trials
Learn about the different clinical trials we offer.
Giving
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Fellowship Programs and Training Opportunities
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