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Bradley Pearce Ander, Ph.D., M.B.A.
Associate Adjunct Professor
Specialties
Bioinformatics (Artificial Intelligence/Machine Learning)
Neurology
Systems Biology
Department
Locations and Contact
Additional Numbers
Physician Referrals
Research/Academic Interests
Dr. Ander is interested in understanding the gene expression response after brain injury. He studies the relationships between different types of RNA molecules and how we can use this knowledge to improve therapies and treatment. He also looks at how individual genetic variation can contribute to unique transcriptional responses of RNA.
Ribonucleic acids (RNA) are the intermediary between DNA and protein, and they are highly dynamic in response to disease or injury. The interplay between coding and non-coding transcripts ultimately regulates and gives rise to biological processes and functions that allow complex cellular systems to function. In the transition from normal to pathophysiological condition, the balance of these interactions can shift. As we learn more about how these interactions are regulated, we can also focus on developing molecular interventions that improve health.
Dr. Ander has studied gene expression in neurological, neurodevelopmental and neurodegenerative disorders such as stroke, autism and Alzheimer’s disease incorporating the latest bioinformatics tools and techniques to analyze these and other disorders with his collaborators.
Division
Neurology
Undergraduate School
B.S., University of Winnipeg, Winnipeg, Manitoba, Canada 1999
Other School
M.B.A., Analytics, UC Davis, Davis CA 2018
Other School
Ph.D., Physiology, University of Manitoba, Winnipeg, Manitoba, Canada 2006
Fellowship
Neurology, Post-Doctoral Fellow, UC Davis, Davis CA 2006-2011
Supporting Education Excellence in Diversity (SEED) program (certification), UC Davis Medical Center, 2020
American Heart Association-Bugher Foundation: Bugher Fellow for Stroke 2009, 2010, 2011
Grant Pierce Award for Excellence in Cardiovascular Research, 2008
Heart & Stroke Foundation of Canada Postdoctoral Fellowship 2006, 2007, 2008
Henry Friesen Young Scientist Award, 2007
St. Boniface General Hospital Foundation Inc. Award for Cardiovascular Biology, 2006
Heart & Stroke Foundation of Canada Doctoral Research Award 2004, 2005, 2006
University of Manitoba Duff Roblin Fellowship 2003, 2004
Canadian Interuniversity Athletic Union Academic All-Canadian 1995, 1996, 1997, 1998, 1999, 2000
Governor General of Canada's Academic Medal - Bronze, 1995
Mike Klim Memorial Award, 1995
A complete list of Dr. Ander's peer-reviewed publications can be found at PubMed: https://www.ncbi.nlm.nih.gov/pubmed?term=3DAnder%20BP%5BAuthor%5D
Sykes GP, Kamtchum-Tatuene J, Falcione S, Zehnder S, Munsterman D, Stamova B, Ander BP, Sharp FR, Jickling G. Aging Immune System in Acute Ischemic Stroke: A Transcriptomic Analysis. Stroke. 2021 Apr;52(4):1355-1361. doi:10.1161/STROKEAHA.120.032040. Epub 2021 Mar 1. PMID:33641386.
Durocher M, Knepp B, Yee A, Jickling G, Rodriguez F, Ng K, Zhan X, Hamade F, Ferino E, Amini H, Carmona-Mora P, Hull H, Ander BP, Sharp FR, Stamova B. Molecular Correlates of Hemorrhage and Edema Volumes Following Human Intracerebral Hemorrhage Implicate Inflammation, Autophagy, mRNA Splicing, and T Cell Receptor Signaling. Transl Stroke Res. 2020 Nov 18. doi:10.1007/s12975-020-00869-y. Epub ahead of print. PMID:33206327.
Dykstra-Aiello C, Sharp FR, Jickling GC, Hull H, Hamade F, Shroff N, Durocher M, Cheng X, Zhan X, Liu D, Ander BP, Stamova BS. Alternative Splicing of Putative Stroke/Vascular Risk Factor Genes Expressed in Blood Following Ischemic Stroke Is Sexually Dimorphic and Cause-Specific. Front Neurol. 2020 Oct 22;11:584695. doi:10.3389/fneur.2020.584695. PMID:33193047.
Durocher M, Ander BP, Jickling G, Hamade F, Hull H, Knepp B, Liu DZ, Zhan X, Tran A, Cheng X, Ng K, Yee A, Sharp FR, Stamova B. Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage. J Neuroinflammation. 2019 Mar 5;16(1):56. doi:10.1186/s129 74-019-1433-4. PMID:3083699.
Shroff N, Ander BP, Zhan X, Stamova B, Liu D, Hull H, Hamade FR, Dykstra-Aiello C, Ng K, Sharp FR, Jickling GC. HDAC9 Polymorphism Alters Blood Gene Expression in Patients with Large Vessel Atherosclerotic Stroke. Transl Stroke Res. 2019 Feb;10(1):19-25. doi:10.1007/s12975-018-0619-x. Epub 2018 Apr 13. PMID:29651704.
Lv B, Cheng X, Sharp FR, Ander BP, Liu DZ. MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats. Front Neurosci. 2018 Oct 24;(12):767. doi:10.3389/fnins.2018.00767. eCollection 2018 PMID:30405345.
Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2018 Apr 13:271678X18769513. doi:10.1177/0271678X18769513. [Epub ahead of print] PMID:29651892.
Ye Z, Ander BP, Sharp FR, Zhan X. Cleaved β-Actin May Contribute to DNA Fragmentation Following Very Brief Focal Cerebral Ischemia. J Neuropathol Exp Neurol. 2018 Mar 1;77(3):260-265. doi:10.1093/jnen/nly003. PMID:29408985.
Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2018 Jan 1. doi:10.1177/0271678X18769513.