Current Trials and Studies

Title: Autologous Muscle Derived Cells for Treatment of Tongue Dysphagia (REVIVE)

Experimental stem cell therapy for swallowing disorders resulting from treatment for head and neck cancer.

ClinicalTrials.Gov Identifier: NCT05421689, UC Davis IRB#1851097

Description of the Clinical Trial: To compare the potential benefits of muscle stem cells injected into the tongue in subjects with moderate swallowing difficulty from head and neck cancer treatment to placebo. This is a double-blind, randomized, placebo-controlled Phase II clinical trial.

Principal Investigator: Peter Belafsky, M.D., M.P.H., Ph.D., Department of Otolaryngology

Study Website: https://studypages.com/s/stem-cell-clinical-trial-for-swallowing-disorders-revive-460666/

Study In-Take Questionnaire: https://ucdavis.co1.qualtrics.com/jfe/form/SV_4O9WMsjw9EKto6q

For questions about this clinical trial, please email: HS-ENTStemCell@ucdavis.edu.

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu

Research joint email address: HS-OTO Study hs-oto-study@ou.ad3.ucdavis.edu

Title: Factors Related to Hearing Loss in the Uninsured Population

ClinicalTrials.gov Identifier: UC Davis IRB#2083097

Description of Research Study: There is currently no data describing the hearing loss rate among the uninsured population. By measuring the hearing loss rate among the uninsured population, we would be able to report the rate of hearing loss in this unique population, and shed light on contributing factors and associated disabilities that result from the hearing loss.  Data collection will occur at local Sacramento Student-run clinics.

Principal Investigator: Doron Sagiv M.D., Department of Otolaryngology

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu

Title: Exercise and Nutritional Prehabilitation for Head and Neck Cancer Patients

ClinicalTrials.gov Identifier: UC Davis IRB#2072911

Description of Research Study: Assess the acceptability, feasibility, and safety to establish a 2-week prehabilitation exercise and nutrition program for head and neck cancer patients. 

Principal Investigator: Marianne Abouyared M.D., Department of Otolaryngology

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu

Title: Predicting Cochlear Implant Outcomes in the Elderly: Speech Comprehension and Quality of Life

ClinicalTrials.gov Identifier: UC Davis IRB#2071014

Description of Research Study: This study will use a standard clinical audiological exam, a series of behavioral and survey questions, and a task while subjects listen to speech at a comfortable volume and while EEG (electroencephalography) is recorded. Patients will participate for 1 year and complete 4 study visits.

Principal Investigator: Doron Sagiv M.D., Department of Otolaryngology

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu

Title: Health Domains for Children with Cleft Palate

ClinicalTrials.gov Identifier: UC Davis IRB#1692650

Description of Research Study: The purpose of this study is to see which areas in health are most concerning for parents with children with cleft palate at different ages.

Principal Investigator: Jamie Funamura M.D., M.P.H., Department of Otolaryngology

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu

Title: Lyra Shell - ENLIGHTEN 1: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis (CRS) in Adults

ClinicalTrials.gov Identifier: NCT05295459, UC Davis IRB#1860452

Description of Research Study: The purpose of this study is to find out if a study product, that had a slow-release drug matrix which is inserted in the nostrils works and is safe in participants with chronic rhinosinusitis.

Principal Investigator: Toby Steele M.D., Department of Otolaryngology

Research Coordinator: Randev Sandhu, UC Davis Department of Otolaryngology, 916-734-2863, rssandhu@ucdavis.edu