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Kristin Nicole Grimsrud, D.V.M., Ph.D., C.V.A., C.C.R.V.
Associate Clinical Professor, Department of Pathology
Associate Director of Vivaria and Veterinary Care, Mouse Biology Program
Shriners Children's Neil Reitman Endowed Professor in Pediatric Burn Research, Shriners Children's Northern California
Kristin Nicole Grimsrud is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Specialties
Veterinarian Medicine
Pharmacology and Toxicology
Department
Locations and Contact
Additional Numbers
Physician Referrals
Philosophy of Care
My clinical focus is on the care and oversight of laboratory rodents, particularly mice and rats, used in biomedical research. I support a broad range of studies, including those involving genetic modification, metabolism, surgery, vaccine development, and pharmacology. I have additional interests in pathogen biosecurity, infectious disease management in vivaria, and the use of animal models to inform special population pharmacology and translational medicine.
A central theme of my work is the application of pharmacogenetics to improve drug safety and efficacy. I investigate how genetic variation influences drug metabolism and response, particularly in opioids, with the goal of personalizing therapy for vulnerable populations. My human clinical research focuses on pediatric and burn patients, populations that often face heightened risks of adverse drug reactions due to complex physiology and developmental variation. By combining pharmacogenetic insights with translational models, I aim to optimize anesthetic and analgesic dosing regimens and advance precision medicine in critically ill and medically complex patients.
Clinical Interests
Dr. Grimsrud is dedicated to providing the highest standard of care for research animals, with a focus on minimizing stress, reducing discomfort, and promoting overall well-being. Her clinical research is driven by a commitment to improving human patient care by advancing pharmacological understanding, particularly in the context of interindividual variability in drug metabolism and response. Through her work, she aims to enhance both animal welfare, translational research outcomes, and improve drug effiacy and pain management in human patient populations.
Research/Academic Interests
Kristin Grimsrud’s research focuses on improving drug dosing and safety in vulnerable populations through the integration of pharmacogenetics, translational models, and precision medicine. She studies how genetic variation influences anesthetic and analgesic drug metabolism, with a particular emphasis on pediatric and burn patients. Her work bridges preclinical rodent models and human clinical research to inform individualized treatment strategies and advance care in critical and complex medical settings.
Center/Program Affiliation
Undergraduate School
B.S., Animal Biology, UC Davis, Davis CA 2006
Other School
Ph.D., Pharmacology and Toxicology, UC Davis, Davis CA 2012
Other School
D.V.M., UC Davis School of Veterinary Medicine, Davis CA 2011
Residency
Laboratory Animal Medicine, UC Davis, Davis CA 2013-2015
Fellowship
PostDoc Cardiothorasic Surgery, UC Davis School of Medicine, Sacramento CA 2015-2016
Top 5 Abstract, American Burn Association, 2022
Research Poster Award, UCD Human Genomics Symposium, 2019
Clinical Research Award, American Burn Association, 2018
Buck Scholarship Recipient 2002-2012,
Veterinary Scientist Training Program Fellow, Dual DVM/PhD Program 2006-2012,
McNew JF, Davis DJ, Grimsrud KN, Bryda EC. Comparison of Thermal and Mechanical Pain Testing Modalities in Sprague Dawley and Fischer 344 Rats (Rattus norvegicus). J Am Assoc Lab Anim Sci. 2024 Mar 8. doi: 10.30802/AALAS-JAALAS-23-000094. Epub ahead of print. PMID: 38458616.
Zheng JX, Randall S, Grimsrud K, Bainbridge S, Tran NK. Not Carfentanil-A Case of Unexpected Xylazine Detection. J Appl Lab Med. 2024 May 2;9(3):629-634. doi: 10.1093/jalm/jfad119. PMID: 38300830.
Grimsrud KN, Davis RR, Tepper CG and Palmieri TL. Pharmacogenetic gene-drug associations in pediatric burn and surgery patients. Journal of Burn Care & Research. 2022 May 10:irac062. doi: 10.1093/jbcr/irac062. Epub ahead of print. PMID: 35639664.
Shankar SP, Grimsrud K, Lanoue L, et al.,. DPH5 dysfunction: a novel 1 cause of embryonic lethality or profound neurodevelopmental disorder recapitulated in a mouse model. Genetics in Medicine. 2022 Jul;24(7):1567-1582. doi: 10.1016/j.gim.2022.03.014. Epub 2022 Apr 28. PMID: 35482014.
Fuetsch SR, Stewart LA, Imai DM, Beckett LA, Li Y, Lloyd KCK, Grimsrud KN. Injection Reactions after Administration of Sustained-release Meloxicam to BALB/cJ, C57BL/6J, and Crl:CD1(ICR) Mice. J Am Assoc Lab Anim Sci. 2021 Jan 5. doi:10.30802/AALAS-JAALAS-20-000042. Epub ahead of print. PMID:33402233.
Grimsrud KN, Lima KM, Tran NK, Palmieri TL. Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients. J Burn Care Res. 2020 Jan 30;41(1):8-14. doi:10.1093/jbcr/irz144. PMID:31538188.
Grimsrud KN, Ivanova X, Sherwin CM, Palmieri TL, Tran NK. Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. J Burn Care Res. 2019 Jan 1;40(1):91-96. doi:10.1093/jbcr/iry053. PMID:30371861.
Steele AN, Grimsrud KN, Sen S, Palmieri TL, Greenhalgh DG, Tran NK. Gap analysis of pharmacokinetics and pharmacodynamics in burn patients: a review. J Burn Care Res. 2015 May-Jun;36(3):e194-211. doi:10.1097/BCR.0000000000000120. PMID:25942648.
Sherwin CM, Stockmann C, Grimsrud K, Herd DW, Anderson BJ, Spigarelli MG. Development of an optimal sampling schedule for children receiving ketamine for short-term procedural sedation and analgesia. Paediatr Anaesth. 2015 Feb;25(2):211-6. doi:10.1111/pan.12521. Epub 2014 Sep 12. PMID:25212712.
Grimsrud KN, Sherwin CM, Constance JE, Tak C, Zuppa AF, Spigarelli MG, Mihalopoulos NL. Special population considerations and regulatory affairs for clinical research. Clin Res Regul Aff. 2015;32(2):47-56. doi:10.3109/10601333.2015.1001900. PMID:26401094.