Alaa Afify, M.D.

Alaa M. Afify, M.D.



Pathology and Laboratory Medicine

Pathology - Anatomic



  • Director of Cytopathology
  • Professor


To see if Alaa M. Afify is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Pathology Building

4400 V St.
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Philosophy of Care

Dr. Afify's philosophy is that patient care comes first under all circumstances, and never to delay any work.

Clinical Interests

Dr. Afify's subspecialty is cytopathology, including fine-needle aspiration cytology, body fluids and Pap tests. He is a recognized expert in performing and evaluating fine-needle aspiration biopsies. Other areas of expertise include gynecologic and endocrine pathology.

Research/Academic Interests

Dr. Afify has research interests in hyaluronan and its receptor, CD44. He is researching the role of CD44 on cancer, including its effects on cell migration, invasion and proliferation. Recently, his lab is developing immunoliposomes that will target specific cancer cells.



Center/Program Affiliation

UC Davis Comprehensive Cancer Center


M.D., Alexandria University and School of Medicine, Alexandria, 1981

Internship: Woodhull Medical and Mental Health Center, New York City NY 1991-1992


Anatomic Pathology & Clinical Pathology, Brown University School of Medicine, Providence RI 1992-1996


Cytopathology, Washington University School of Medicine, St. Louis MO 1997-1998

Oncologic Surgical Pathology, Roswell Park Cancer Institute, Buffalo NY 1996-1997

Board Certifications

American Board of Pathology, Anatomic and Clinical Pathology, 1997

American Board of Pathology, Cytopathology, 1998

Professional Memberships

American Society of Cytopathology

College of American Pathologists

United States and Canadian Academy of Pathology

Honors and Awards

Best graduating resident of the year, 1996

Select Recent Publications

Afify AM, Tate S, Durbin-Johnson B, Rocke DM, Konia T. Expression of CD44s and CD44v6 in lung cancer and their correlation with prognostic factors. Int J Biol Markers. 2011 Jan-Mar;26(1):50-7.

Devaraj S, Tobias P, Kasinath BS, Ramsamooj R, Afify A, Jialal I. Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1796-804. Epub 2011 May 26

Alaa Afify and Lydia Howell. Cervical cancer screening, effective clinician and laboratory partnership. J of female patient, 2010 35(8):27-29.

Afify A, Purnell P, Nguyen L. Role ofCD44s and CD44v6 on human breast cancer cell adhesion, migration, and invasion. Exp Mol Pathol, 86(2): 95-100. 2009

Afify A, Yu C, Hejazi N, Howell L. The Diagnostic Utility of Cell Blocks Prepared From Residual SurePath Pap Material for Detection of Human Papilloma Virus. Appl Immunohistochem Mol Morphol, 95-100. 2009

Howell LP, Wilton M, Bishop J, Afify A. Living with uncertainty: Equivocal Pap test results and the evolution of ASC terminology. Diagn Cytopathol. 2009 Oct 23. [Epub ahead ofprint] PMID: 19856423

Singh U, Dasu MR, Yancey PG, Afify A, Devaraj S, Jialal 1.Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats. J Lipid Res, 49(5): 1015-23. 2008

Afify A, McNiel MA, Braggin J, Bailey H, Paulino AF. Expression of CD44s, CD44v6, and hyaluronan across the spectrum of normal-hyperplasia-carcinoma in breast. Appl Immunohistochem Mol Morphol, 16(2): 121-7. 2008

Afify AM, Lin-Chang L, Howell L. Correlation of Cytologic Examination with ELISA Assays for Hyaluronan and Soluble CD44v6 Levels in Evaluation of Effusions. Diagnostic cytopathology, 35: 105-110. 2007

Afify AM, Pang L, Howell L. Diagnostic Utility of CD44 standard, CD44v6, and CD44v3-10 Expression in Adenocarcinomas Presenting in Serous Fluids. Applied Immunohistochemistry & Molecular Morphology, 15(4): 446-50. 2007