James Scott Trimmer, Ph.D.
Distinguished Professor, Department of Physiology and Membrane Biology
Locations and Contact
Research/Academic Interests
Dr. Trimmer's research focuses on improving our understanding of brain function in health and disease. This includes studies of ion channel signaling complexes in neurons and their role in neurophysiology and their disruption in disease. He also directs a long running program aimed at generating renewable and recombinant antibodies for neuroscience research.
Undergraduate School
B.A., Biology, UC San Diego, La Jolla CA 1981
Other School
Ph.D., Marine Biology, Scripps Institution of Oceanography, UC San Diego, La Jolla CA 1987
Fellowship
Physiology, Yale School of Medicine, New Haven CT 1987-1990
Research Award, UC Davis School of Medicine, 2020
Clarivate Highly Cited Researcher (top 1% in field), 2019, 2020
Faculty Award for Excellence in Service to Graduate Students, UC Davis Graduate Student Association, 2014
Jacob Javits Neuroscience Investigator (MERIT) Award, NINDS/NIH 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007
Established Investigatorship, American Heart Association, 1994, 1995, 1996, 1997, 1998, 1999
To view a detailed list of Dr. Trimmer's publications, please click here.
Vierra NC, O'Dwyer SC, Matsumoto C, Santana LF, Trimmer JS. Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM junctions. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2110094118. doi:10.1073/pnas.2110094118. PMID:34750263.
Vierra NC, Kirmiz M, van der List D, Santana LF, Trimmer JS. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons. Elife. 2019 Oct 30;8:e49953. doi:10.7554/eLife.49953. PMID:31663850.
Dong JX, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, Trimmer JS. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. Elife. 2019 Sep 30;8:e48750. doi:10.7554/eLife.48750. PMID:31566565.
Andrews NP, Boeckman JX, Manning CF, Nguyen JT, Bechtold H, Dumitras C, Gong B, Nguyen K, van der List D, Murray KD, Engebrecht J, Trimmer JS. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain. Elife. 2019 Jan 22;8:e43322. doi:10.7554/eLife.43322. PMID:30667360.
Kirmiz M, Vierra NC, Palacio S, Trimmer JS. Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons. J Neurosci. 2018 Aug 29;38(35):7562-7584. doi:10.1523/JNEUROSCI.0893-18.2018. Epub 2018 Jul 16. PMID:30012696.
Trimmer JS. Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexity. Neuron. 2015 Jan 21;85(2):238-56. doi:10.1016/j.neuron.2014.12.042. PMID:25611506.
Rhodes KJ, Trimmer JS. Antibodies as valuable neuroscience research tools versus reagents of mass distraction. J Neurosci. 2006 Aug 2;26(31):8017-20. doi:10.1523/JNEUROSCI.2728-06.2006. PMID:16885215.
Park KS, Mohapatra DP, Misonou H, Trimmer JS. Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science. 2006 Aug 18;313(5789):976-9. doi:10.1126/science.1124254. PMID:16917065.
Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS. Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci. 2004 Jul;7(7):711-8. doi:10.1038/nn1260. Epub 2004 Jun 13. PMID:15195093.