In trauma, often the injuries are much more than the cuts and bruises and fractures. Treating the whole patient requires true empathy and a kind of humility and willingness to consider that it is difficult to completely understand the complexity of another person's lived experience but essential to try. I like to think that we do much more than procedures and operations and that the impact of our care should extend well beyond when the patient leaves our door.
Ian Brown has a broad interest in trauma with a particular focus on acute coagulopathy and endotheliopathy in trauma. Additionally, he has a strong interest in curbing violence-related trauma recidivism and is a co-founder of the UC Davis Wraparound Hospital-based Violence Intervention Program.
In Dr. Brown's role as a surgeon and researcher, he has two primary interests. The first is in understanding the intersection between coagulation and inflammation in the setting of acute severe trauma and how this interplay impacts outcomes through consequences of coagulopathy and endotheliopathy. His second focus is on social determinants health that contribute to violence-related trauma recidivism and how hospital-based violence intervention programs (HVIP) such as the UC Davis Wraparound HVIP can disrupt cycles of violence through trauma-informed, culturally competent interventions.
Our lab investigates the role of cell-adhesion molecules such as P-selectin in inflammatory processes and intravascular thromboembolic injury in the setting of trauma. We previously developed a model of blunt thoracic trauma and found that in situ pulmonary arterial thrombosis (PAT) in the model was dependent on the presence of the cell adhesion molecule P-selectin. By understanding the natural history of PAT and the role and regulation of P-selectin in this history, we seek to help determine the necessity of intervention and to investigate the efficacy of P-selectin blockade as an alternative to anti-coagulation for intervention. More broadly, cell adhesion molecules such as P-selectin likely play a role in thrombosis in the setting of vascular injury, vascular repair, injuries of ischemia and reperfusion, and potentially in the setting of infection and sepsis. Understanding the biology of cell adhesion molecules such as P-selectin may therefore contribute to the continuing evolution of resuscitation paradigms that improve trauma-associated outcomes.
With the Wraparound HVIP, we incorporate trauma-informed, relationship-based mentoring, culturally affirming case management, and partnerships with natural and community supports to facilitate holistic recovery from violent injury and reduce the risk for future violence involvement. Our Violence Intervention Specialists are trained to use a foundation of cultural competency and lived experience to provide crisis intervention, case management, mentoring, and connection to community resources. We use a mixed methods approach with quantitative and qualitative data analysis to understand the social determinants that contribute to violence-related trauma and to evaluate the impact and efficacy of interventions.
B.S., Stanford University, Palo Alto CA 1997
M.D., University of Chicago, Pritzker School of Medicine, Chicago IL 2007
Ph.D., Immunology, University of Chicago, Chicago IL 2005
General Surgery, UC San Francisco Medical Center, San Francisco CA 2007-2008
General Surgery, UC San Francisco Medical Center, San Francisco CA 2007-2014
Trauma and Surgical Critical Care, UC Davis Medical Center, Sacramento CA 2014-2015
American Surgical Association Foundation Fellowship Research Award, 2020
American Association for the Surgery of Trauma, Acute Care Surgery Research Scholarship, 2019
UCSF Azakie-Chesson Award for Compassion in Surgery, 2014
Brown IE. Comment on "The Long-term Risk of Venous Thromboembolism After Blunt Splenic Injury Managed by Embolization". Ann Surg. 2020 Mar;271(3):e101. doi:10.1097/SLA.0000000000003761. PMID:32079831.
Schutzman LM, Rigor RR, Khosravi N, Galante JM, Brown IE. P-Selectin is Critical for De Novo Pulmonary Arterial Thrombosis following Blunt Thoracic Trauma. J Trauma Acute Care Surg. 2019 Apr;86(4):583-591. doi:10.1097/TA.0000000000002166.
Brown IE, Rigor RR, Schutzman LM, Khosravi N, Chung K, Becker JA, Pivetti CD, Best GT, Chavez JC, Galante JM. Pulmonary arterial thrombosis in a murine model of blunt thoracic trauma. Shock. 2018 Dec;50(6):696-705. doi:10.1097/SHK.0000000000001109.
Iverson KT, Curtis E, Salcedo E, Anderson J, Brown I. New Fragmenting Bullet Leads to Unexpected Injury Pattern: a Case Report involving the Radically Invasive Projectile. Trauma. 2018 Mar 25. doi:10.1177/1460408618759365.
Anderson JE, Brown IE, Olson KA, Iverson, K, Cocanour CS, Galante, JM. Non-occlusive Mesenteric Ischemia in Patients with Methamphetamine Use. J Trauma Acute Care Surg. 2018 Jun;84(6):885-892. doi:10.1097/TA.0000000000001855.
Salcedo ES, Brown IE, Corwin MT, Galante JM. Pelvic angioembolization in trauma - Indications and outcomes. Int J Surg. 2016 Sep;33(Pt B):231-236. doi:10.1016/j.ijsu.2016.02.057. Epub 2016 Feb 18.
Brown I, Bellevue O, Shawo A, Woldesemayat H, Lyo V, Rayikanti B, Lee M, Uzosike E, Kasravi S, Harris HW. Low dose cyclophosphamide improves survival in a murine treatment model of sepsis. Shock. 2015 Jan;43(1):92-8. doi:10.1097/SHK.0000000000000263.
Kline J, Brown I, Zha Y, Blank C, Strickler C, Wouters H, Zhang L, Gajewski, TF. Homeostatic proliferation plus regulatory T cell depletion promotes potent rejection of B16 melanoma. Clin Cancer Res. 2008 May 15;14(10):3156-67. doi:10.1158/1078-0432.CCR-07-4696.
Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, Brown I, Praveen K, Stang S, Stone JC, Gajewski TF. T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase. Nat Immunol. 2006 Nov;7(11):1166-73. doi:10.1038/ni1394. Epub 2006 Oct 8.
Brown IE, Blank C, Kline J, Kacha AK, Gajewski TF. Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. J Immunol. 2006 Oct 1;177(7):4521-9. doi:10.4049/jimmunol.177.7.4521.