Aili Guo, M.D. for UC Davis Health

Aili Guo, M.D.

Health Sciences Clinic Professor, Division of Endocrinology

To see if Aili Guo is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).




Locations and Contact

Lawrence J. Ellison Ambulatory Care Center

Lawrence J. Ellison Ambulatory Care Center
4860 Y St.
Sacramento, CA 95817

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UC Davis Medical Group - Sacramento (Campus Commons)

UC Davis Medical Group - Sacramento (Campus Commons)
500 University Avenue, Ste. 220
Sacramento, CA 95825

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Phone: 916-286-8700

Additional Numbers

Clinic Phone


Clinic Phone


Physician Referrals

800-4-UCDAVIS (800-482-3284)

Philosophy of Care

My philosophy of care is to treat every patient with respect and dedication, and to deliver evidence-based patient-centered high-quality care at UC Davis.

Clinical Interests

Dr. Guo is a board-certified endocrinologist offering care to patients with various endocrine conditions such as thyroid disease, diabetes mellitus, osteoporosis, parathyroid disease, and others.

Research/Academic Interests

Dr. Guo has done research in the past relating to thyroid nodule evaluation, promotion of pancreatic β-cell preservation and therapeutic stratigies in diabetes mellitus, and neuroendocrine-immune crosstalk in hypothalamic pituitary adrenal axis function. Currently she is part of a multidisciplinary research team at UC Davis to improve the diagnosis and linkage-to-care of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes. This is the patient population associated with an increased risk of death. Dr. Guo also enjoys teaching medical students, residents and endocrine fellows, in particular thyroid functional disease.


Endocrinology, Diabetes, and Metabolism

Center/Program Affiliation

UC Davis Medical Group

Undergraduate School

B.S., Sun Yat-Sen University of Medical Sciences, Guangzhou China 1983

Medical School

M.D., Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 1989


Internal Medicine, University of Utah School of Medicine, Salt Lake City UT 2005-2007


Internal Medicine/Endocrinology, University of Utah School of Medicine, Salt Lake City UT 2007-2010

Chen X, Daniels NA, Cottrill D, Cao Y, Wang X, Li Y, Shriwas P, Qian Y, Archer MW, Whitticar NB, Jahan I, Nunemaker CS, Guo A. Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism. Diabetes Metab Syndr Obes. 2021 Feb 24;14:759-772. doi:10.2147/DMSO.S284295. PMID:33658814.

Guo A, Kaminoh Y, Forward T, Schwartz FL, Jenkinson S. Fine Needle Aspiration of Thyroid Nodules Using the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience in a Rural Setting. Int J Endocrinol. 2017;2017:9601735. doi:10.1155/2017/9601735. Epub 2017 Feb 9. PMID:28280507. 

Guo A, Daniels NA, Thuma J, McCall KD, Malgor R, Schwartz FL. Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice. PLoS One. 2015 Jan 29;10(1):e0117556. doi:10.1371/journal.pone.0117556. PMID:25633992.

Slepchenko KG, Daniels NA, Guo A, Li YV. Autocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion. Endocrine. 2015 Sep;50(1):110-22. doi:10.1007/s12020-015-0568-z. Epub 2015 Mar 15. PMID:25771886.

Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. Mol Cell Biol. 2015 Mar;35(5):831-46. doi:10.1128/MCB.01109-14. Epub 2014 Dec 22. PMID:25535334.

Schwartz FL, Guo A, Marling CR, Shubrook JH. Analysis of use of an automated bolus calculator reduces fear of hypoglycemia and improves confidence in dosage accuracy in type 1 diabetes mellitus patients treated with multiple daily insulin injections. J Diabetes Sci Technol. 2012 Jan 1;6(1):150-2. doi:10.1177/193229681200600118. PMID:22401333.

Shubrook J, Colucci R, Guo A, Schwartz F. Saxagliptin: A Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. Clin Med Insights Endocrinol Diabetes. 2011;4:1-12. doi:10.4137/CMED.S5114. Epub 2011 Jan 12. PMID:22879789.

O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306. doi:10.1016/j.cmet.2007.09.001. PMID:17908558.

Guo A, Nie F, Wong-Riley M. Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system. J Comp Neurol. 2000 Feb 7;417(2):221-32. doi:10.1002/(sici)1096-9861(20000207)417:2<221::aid-cne7>;2-4. PMID:10660899.

Wong-Riley M, Guo A, Bachman NJ, Lomax MI. Human COX6A1 gene: promoter analysis, cDNA isolation and expression in the monkey brain. Gene. 2000 Apr 18;247(1-2):63-75. doi:10.1016/s0378-1119(00)00121-9. PMID:10773445.