Paul J. Hagerman, M.D., Ph.D. for UC Davis Health

Paul J. Hagerman, M.D., Ph.D.

Professor, Department of Biochemistry and Molecular Medicine

MIND Institute Investigator



Molecular Genetics

Locations and Contact

Tupper Hall

4455 Tupper Hall
Davis, CA 95616

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Additional Numbers



Research/Academic Interests

Dr. Hagerman's research focuses on the clinical and molecular underpinnings of disorders of the fragile X (FMR1) gene, mutations of which are responsible for fragile X syndrome (FXS) - the leading heritable form of intellectual impairment, fragile X-associated primary ovarian insufficiency (FXPOI) - the leading heritable form of early menopause, and fragile X-associated tremor/ataxia syndrome (FXTAS) - one of the leading single-gene forms of neurodegeneration. The Hagerman lab is particularly interested in the "RNA toxicity" model for FXTAS, both in terms of identifying the key players in the pathogenesis of this disorder and for therapeutic targeting of the pathogenic mechanism.


Biological Chemistry

Center/Program Affiliation

UC Davis MIND Institute

Undergraduate School

B.A., Chemistry, University of Oregon, Eugene OR 1971

Medical School

M.D., Stanford University School of Medicine, Stanford CA 1977

Other School

Ph.D., Biochemistry, Stanford University School of Medicine, Stanford CA 1977


Chemistry/Leukemia Society, UC San Diego, La Jolla CA 1977-1980

Distinguished Professor, 2013

UC Davis School of Medicine Research Award, 2011

William Rosen Research Award, National Fragile X Foundation - Outstanding Research on FXS Stallone Fund for Autism Research, 2002

Stallone Fund for Autism Research,

Milheim Foundation Award for Cancer Research,

To view all of Dr. Hagerman's publications on PubMed, visit:

Holm KN, Herren AW, Taylor SL, Randol JL, Kim K, Espinal G, Martiínez-Cerdeño V, Pessah IN, Hagerman RJ, Hagerman PJ. Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome. Front Mol Biosci. 2021 Jan 29;7:600840. doi:10.3389/fmolb.2020.600840. Erratum in: Front Mol Biosci. 2021 May 11;8:695407. PMID:33585555.

Ma L, Herren AW, Espinal G, Randol J, McLaughlin B, Martinez-Cerdeño V, Pessah IN, Hagerman RJ, Hagerman PJ. Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome. Acta Neuropathol Commun. 2019 Sep 3;7(1):143. doi:10.1186/s40478-019-0796-1. PMID:31481131.

Kim K, Hessl D, Randol JL, Espinal GM, Schneider A, Protic D, Aydin EY, Hagerman RJ, Hagerman PJ. Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions. PLoS One. 2019 Dec 31;14(12):e0226811. doi:10.1371/journal.pone.0226811. PMID:31891607.

Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB Jr, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ. Fragile X syndrome. Nat Rev Dis Primers. 2017 Sep 29;3:17065. doi:10.1038/nrdp.2017.65. PMID:28960184.

Robin G, López JR, Espinal GM, Hulsizer S, Hagerman PJ, Pessah IN. Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2017 Jul 15;26(14):2649-2666. doi:10.1093/hmg/ddx148. PMID:28444183.

Pham TT, Yin J, Eid JS, Adams E, Lam R, Turner SW, Loomis EW, Wang JY, Hagerman PJ, Hanes JW. Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications. Mol Genet Genomics. 2016 Jun;291(3):1491-504. doi:10.1007/s00438-016-1167-2. Epub 2016 Jan 29. PMID:26825750.