Jonathan Widdicombe, B.A., D. Phil.
Emeritus Professor, Department of Physiology & Membrane Biology
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Research/Academic Interests
Jonathan Widdicombe's research interests include writing occasional articles on the history of medicine and physiology.
Undergraduate School
B.A., Oxford University, Oxford, England 1970
Medical School
D.Phil., Pharmacology, Oxford University Medical School, Oxford, England 1975
Fellowship
Pharmacology, Oxford University, Oxford, England 1975-1976
Fellowship
Physiology, UC San Francisco, San Francisco CA 1976-1979
Fellowship
University of Alberta, Alberta, 1975-76
Director, NIH SCOR (Cystic Fibrosis Research Center), UCSF (1988-2003), 2003
Mary Morrow Prize for Excellence in Scientific Writing, UCSF, 1980
Widdicombe JH. A Brief History of Bronchitis in England and Wales. Chronic Obstr Pulm Dis. 2020 Oct;7(4):303-314. doi:10.15326/jcopdf.7.4.2020.0135. PMID:32989942.
Widdicombe JH, Wine JJ. Airway Gland Structure and Function. Physiol Rev. 2015 Oct;95(4):1241-319. doi:10.1152/physrev.00039.2014. PMID:26336032.
Uyekubo SN, Fischer H, Maminishkis A, Illek B, Miller SS, Widdicombe JH. cAMP-dependent absorption of chloride across airway epithelium. Am J Physiol. 1998 Dec;275(6):L1219-27. doi:10.1152/ajplung.1998.275.6.L1219. PMID:9843860.
Shen BQ, Finkbeiner WE, Wine JJ, Mrsny RJ, Widdicombe JH. Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am J Physiol. 1994 May;266(5 Pt 1):L493-501. doi:10.1152/ajplung.1994.266.5.L493. PMID:7515578.
Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH. Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol. 1992 Jun;262(6 Pt 1):L713-24. doi:10.1152/ajplung.1992.262.6.L713. PMID:1616056.
Barthelson R, Widdicombe J. Cyclic adenosine monophosphate-dependent kinase in cystic fibrosis tracheal epithelium. J Clin Invest. 1987 Dec;80(6):1799-802. doi:10.1172/JCI113274. PMID:3680529.
Evans DJ, Matsumoto PS, Widdicombe JH, Li-Yun C, Maminishkis AA, Miller SS. Pseudomonas aeruginosa induces changes in fluid transport across airway surface epithelia. Am J Physiol. 1998 Nov;275(5):C1284-90. doi:10.1152/ajpcell.1998.275.5.C1284. PMID:9814977.
Zabner J, Smith JJ, Karp PH, Widdicombe JH, Welsh MJ. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Mol Cell. 1998 Sep;2(3):397-403. doi:10.1016/s1097-2765(00)80284-1. PMID:9774978.
Lee MC, Penland CM, Widdicombe JH, Wine JJ. Evidence that Calu-3 human airway cells secrete bicarbonate. Am J Physiol. 1998 Mar;274(3):L450-3. doi:10.1152/ajplung.1998.274.3.L450. PMID:9530182.
Zhang L, Wang D, Fischer H, Fan P-D, Widdicombe JH, Kan YW, Dong J-Y. Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes. Proc Natl Acad Sci USA. 1998;95(17):10158-10163. doi:10.1073/pnas.95.17.10158.