• Bioengineered Model of the Bone Marrow to Study and Combat Cancer

    Leach Lab

Research in the Leach laboratory is in the broad area of biomaterials and tissue engineering to address key clinical challenges affecting society. We seek to engineer functional replacement and temporary bridge tissues while also developing model systems to study physiological and pathophysiological tissue formation. Our projects are broad in scope, pursuing innovative research in bone, muscle, cartilage, and skin tissue engineering, as well as developing approaches to interrogate and combat cancer. Furthermore, we use these platforms to explore tissue crosstalk to better understand the interplay of organ system homeostasis and repair.

All projects in the lab are linked by the hypothesis that combinatorial approaches to tissue formation are superior to individual stimulation. More specifically, successful tissue engineering approaches will be realized upon the proper spatial and temporal presentation of cells, signaling molecules, biomaterials, and mechanical stimulation.

Leach Lab photo taken in April 2024 in front of the Oak Park research building Orthopaedic Surgery department sign

David H. Ramos, Ph.D. -- Postdoctoral Fellow
           
Katherine Griffin -- Graduate Student
           
Sabrina Mierswa -- Graduate Student
           
Shierly Fok Lau, M.S. -- Graduate Student
           
Andie Filler -- Graduate Student
           
Alex S. Kermani, M.S. -- Graduate Student
           
Erika Wheeler, M.S. -- Graduate Student
           
Langston Wu -- Undergraduate Student

  • Member, Biomedical Engineering Society (BMES)
  • Member, Society for Biomaterials (SFB)
  • Member, Tissue Engineering and Regenerative Medicine International Society (TERMIS)
  • Member, Orthopaedic Research Society (ORS)

Motivation

Our laboratory is interested in determining the proper mixture of stimulatory signals to induce the formation and regeneration of various tissues. We utilize our expertise in biomaterials, drug and gene delivery, and mammalian cell culture to develop model systems for the investigation of tissue regeneration. We have ongoing projects in the engineering of numerous tissues, including bone, blood vessels, cornea, and wound healing.  

Projects

  • Biomaterials-based strategies to induce angiogenesis
  • Controlling the oxygen microenvironment to manipulate cellular behavior
  • Cell-cell interactions to promote tissue formation
  • Development of biomimetic materials for use in bone tissue engineering
  • Development of novel systems for sustained gene delivery
  • Validation of tissue regeneration using noninvasive in vivo imaging modalities

State of Minds: Air Quality, Stem Cells, Peace Corps, Neanderthal Genome (See one of our collaborations starting at 18:51) http://www.uctv.tv/search-details.aspx?showID=20692

Leach Lab Healing Bones You Tube Video    

  • Program co-chair, BMES 2020 Annual Meeting
  • Fellow, Biomedical Engineering Society (BMES), Class of 2018
  • Member, University of Oklahoma Gallogly College of Engineering Board of Visitors, 2018-present
  • College of Fellows, American Institute for Medical and Biological Engineering (AIMBE), 2017
  • Standing member, Biomaterials and Biointerfaces (BMBI) Study Section, NIH, 2016-2020
  • Fellowship Award for Excellence in Mentoring, UC Davis Office of Graduate Studies, 2015
  • University of Oklahoma College of Engineering Samuel Wilson Lectureship, 2015
  • UC Davis College of Engineering Outstanding Faculty Teaching Award, 2014
  • Page Morton Hunter Distinguished Lecturer, Clemson University, 2012
  • UC Davis Mid-Career Leadership Program Participant, 2011
  • NIH Loan Repayment Program Award, 2010
  • The Hartwell Foundation Individual Biomedical Research Award, 2008
  • NIH National Research Service Award Postdoctoral Fellowship, 2004

Representative recent papers from the Leach lab listed below can all be viewed freely through Open Access. All papers can be found on PubMed through the National Library of Medicine.

  1. Lowen JM, Wheeler E, Shimamoto NK, Ramos-Rodriguez DH, Griffin KH, Bond GC, Leach JK. Functionalized annealed microgels for spatial control of osteogenic and chondrogenic differentiation of mesenchymal stromal cells. In press, Advanced Functional Materials. https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202311017
  2. Casella A, Lowen JM, Griffin KH, Shimamoto NK, Ramos-Rodriguez DH, Panitch A, Leach JK. Conductive microgel annealed scaffolds enhance myogenic potential of myoblastic cells. Advanced Healthcare Materials 2023; e2302500. PMID: 38069833. https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202302500
  3. Griffin KH, Thorpe SW, Sebastian A, Hum NR, Coonan TP, Sagheb I, Loots GG, Randall RL, Leach JK. Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening. Proceedings of the National Academy of Sciences 2023; 120(39):e2302101120. PMID: 37729195. https://www.pnas.org/doi/full/10.1073/pnas.2302101120
  4. Gresham RCH, Filler AC, Fok SW, Czachor M, Schmier N, Pearson C, Bahney C, Leach JK. Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells. Journal of Biomedical Materials Research Part A 2024; 112(5):770-780. PMID: 38095311. https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37657
  5. Thai VL, Ramos-Rodriguez DH, Mesfin M, Leach JK. Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing. Materials Today Bio 2023; 22: 100769. PMID: 37636986. https://www.sciencedirect.com/science/article/pii/S2590006423002296
  6. Fok SW, Gresham RCH, Ryan W, Osipov B, Bahney C, Leach JK. Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices. Frontiers in Bioengineering and Biotechnology 2023; 11:1091157. PMID: 36756385. https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1091157/full
  7. Gionet-Gonzales MA, Gresham RCH, Griffin KH, Wolgemuth R, Casella AC, Ramos-Rodriquez DH, Lowen J, Smith LR, Leach JK. Mesenchymal stromal cell spheroids in sulfated alginate enhance muscle regeneration. Acta Biomaterialia 2023; 155:271-281. PMID: 36328130. https://www.sciencedirect.com/science/article/pii/S1742706122007115?via%3Dihub
  8. Gonzalez-Fernandez T, Tenorio AJ, Saiz AM, Leach JK. Engineered cell-secreted extracellular matrix modulates cell spheroid mechanosensing and amplifies their response to inductive cues for the formation of mineralized tissues. Advanced Healthcare Materials 2022, 11:e2102337. PMID: 34968011. https://onlinelibrary.wiley.com/doi/10.1002/adhm.202102337

2024

Sept 19, 2024 - Congratulations to Erika Wheeler for advancing to Ph.D. Candidacy!

July 30, 2024 - Congratulations to Katie Griffin for successfully defending her Ph.D. thesis dissertation!

June 10, 2024 - Congratulations to Alex Kermani for advancing to Ph.D. Candidacy! 

May 30, 2024 - Congratulations to Andie Filler for advancing to Ph.D. Candidacy! 

2023

June 2023 - Congratulations to Laney Casella for successfully defending her Ph.D. thesis dissertation!

June 2023 - Congratulations to Bobby Gresham for successfully defending his Ph.D. thesis dissertation!

June 2023 - Congratulations to Jeremy Lowen for successfully defending his Ph.D. thesis dissertation!

2021

Aug. 24, 2021 - Congratulations to Laney Casella for receiving the Achievement Rewards for College Scientists (ARCS) Scholarship!

July 21, 2021 - Congratulations to Marissa Gionet-Gonzales for successfully defending her Ph.D. thesis dissertation!

June 15, 2021 - Congratulations to Laney Casella on being accepted to the Leaders for the Future program!

May 06, 2021 - Congratulations to Bobby Gresham for advancing to Ph.D. candidacy!

May 05, 2021 - Congratulations to Brandon and Tomas for being awarded a Summer VIRC fellowship! The Veterinary Institute for Regenerative Cures awarded a summer fellowship to Brandon Zabaneh and Tomas Gonzalez-Fernandez, Ph.D. for their project entitled, "Engineering a 3D printable gelatin-methacrylate bioink to couple innervation and vascularization for tissue repair". Congratulations!

May 04, 2021 - Congratulations to Laney Casella for being awarded an SWE scholarship! Laney was awarded the 2021 Golden West Region Legacy scholarship through the Society of Women Engineers!

March 18, 2021- Welcome Shierly Fok Lau to the Leach lab!

March 02, 2021 - Welcome Sabrina Mierswa to the Leach lab!

Jan. 28, 2021 - Congratulations to Marissa Gionet-Gonzales for receiving the UC Davis College of Engineering Excellence in Graduate Student Equity, Diversity, and Inclusion Award!

2020

Dec. 21, 2020 - Congratulations to Takeyah Campbell for passing her master’s exam!

Dec. 07, 2020 - Congratulations to Vicky Thai for advancing to Ph.D. candidacy!

Nov. 13, 2020 - Congratulations to Katie Griffin for advancing to Ph.D. candidacy!

Aug. 28, 2020 - Congratulations to Laney Casella for advancing to Ph.D. candidacy!

Aug. 24, 2020 - Congratulations to Jeremy Lowen for advancing to Ph.D. candidacy!

Aug. 13, 2020- Congratulations to Charlotte Vorwald for successfully defending her Ph.D. thesis dissertation!

March 12, 2020 - Congratulations to Tomas for being chosen to attend the Nobel Laureate meeting! The University of California’s Office of the President and the Office of the Chief Investment Officer announced the inaugural class of the UC President’s Lindau Nobel Laureate Meetings Fellows, an extraordinary group of 20 young scientists, scholars, and economists selected from nine UC campuses.

Feb. 26, 2020 - Congratulations to Leach lab alum and orthopedic surgeon Augie Saiz for receiving a grant from AO Trauma North America! With this grant, he can perform a spinopelvic biomechanical study. Augie's paper published in Bone has also been selected as a California Orthopaedic Association award-winning paper.

2019

Dec. 10, 2019 - Congratulations to Jackie Woods for successfully defending her Ph.D. thesis dissertation!

Oct. 22, 2019 - Congratulations to Marissa Gionet-Gonzales for being awarded one of the Richard and Joy Dorf Graduate Fellowships!

Sep. 24, 2019 - Congratulations to Jackie Woods (née Whitehead) for winning the 2019 BME Outstanding Graduate Student Award!

June 10, 2019 - Congratulations to Marissa Gionet-Gonzales for advancing to Ph.D. candidacy!

May 16, 2019 - Congratulations to Charlotte Vorwald on being accepted to the Professors for the Future program!

April 27, 2019 - Congratulations to Jackie Whitehead for winning the People’s Choice for Best Oral Presentation award!

April 27, 2019 - Marissa Gionet-Gonzales and Jackie Whitehead gave oral presentations, and Charlotte Vorwald gave a poster presentation on their research at the 8th Annual BMEGG Research Symposium.

April 27, 2019 - Shreeya Joshee presented a poster on her work at the UC Davis 30th Annual Undergraduate Research Conference.

April 27, 2019 - Alex Tenorio presented a poster on his work at the UC Davis 30th Annual Undergraduate Research Conference.

April 11, 2019 - Congratulations to Jackie Whitehead on being awarded a Schwall Dissertation Year Fellowship!

April 09, 2019 - Congratulations to Jeremy Lowen for being awarded the NSF GRFP Honorable Mention!

April 06, 2019 - Marissa Gionet-Gonzales and Tomas Gonzalez-Fernandez gave podium presentations at the 2019 Society for Biomaterials Conference!

March 31, 2019 - Welcome Jeremy Lowen and Vicky Thai to the Leach Lab!

2018

Dec. 01, 2018 - Congratulations to Jenna Harvestine for successfully defending her Ph.D. thesis dissertation!

Nov. 14, 2018 - Congratulations to Tomas Gonzalez-Fernandez for being awarded a Postdoctoral Fellowship from the American Heart Association!

Nov. 01, 2018 - Welcome Bobby Gresham to the Leach Lab!

Oct. 20, 2018 - Kaitlin Murphy Fogg (lab alumna), Jackie Whitehead, and Charlotte Vorwald presented oral presentations at the 2018 BMES Annual Meeting in Atlanta, Georgia

Oct. 20, 2018 - Congratulations to Kent for being named a BMES Fellow!

Sep. 07, 2018 - Kent and Tomas presented at the 5th TERMIS World Congress in Kyoto, Japan.

July 26, 2018 - Congratulations to Osamu Yasui for being selected as a Goldwater Scholarship recipient!

June 27, 2018 - Congratulations to Marissa Gionet-Gonzales for being awarded an NIH Diversity Supplement!

May 24, 2018 - Congratulations to Jackie Whitehead for being awarded an ARCS fellowship!

May 04, 2018 - Jenna Harvestine, Marissa Gionet-Gonzales, Charlotte Vorwald, and Jackie Whitehead gave poster presentations on their research at the 7th Annual BMEGG Research Day

May 03, 2018 - Congratulations to Jackie Whitehead for advancing to Ph.D. candidacy!

March 20, 2018 - Welcome Takeyah Campbell and Laney Casella to the Leach Lab!

Feb. 12, 2018 - Welcome Tomas Gonzalez-Fernandez to the Leach Lab!

2019

Dec. 14, 2017 - Congratulations to Charlotte Vorwald for advancing to Ph.D. candidacy!

Oct. 13, 2017 - Ben Hung, Jenna Harvestine, Charlotte Vorwald, and Jackie Whitehead presented oral presentations at the 2017 BMES Annual Meeting in Phoenix, Arizona

Sep. 21, 2017 - Congratulations to Steve Ho for successfully defending his Ph.D. thesis dissertation!

Aug.31, 2017 - Congratulations to Jenna Harvestine for being selected as a UC Davis Business Development Fellow!

June 14, 2017 - Congratulations to Debika Mitra for successfully defending her Ph.D. thesis dissertation!

June 01, 2017 - Congratulations to Charlotte Vorwald for being awarded a T32 Fellowship in Basic and Translational Cardiovascular Science, funded by the NIH

May 19, 2017 - Congratulations to Jenna Harvestine for winning Best Oral Presentation!

May 19, 2017 - Steve Ho, Debika Mitra, and Jenna Harvestine gave oral presentations, and Charlotte Vorwald and Jackie Whitehead gave poster presentations on their research at the 6th Annual BMEGG Research Day

May 02, 2017 - Jonathan Chen presented a poster on his work with composite scaffolds at the UC Davis 28th Annual Undergraduate Research Conference

April 10, 2017 - Congratulations to Osamu Yasui for being selected as a Beckman Scholar for 2017-2018!

April 03, 2017 - Welcome Marissa Gionet-Gonzales to the Leach Lab!

March 22, 2017 - Leach Lab awarded a new R01 to study dual peptide presentation from bioengineered carriers to potentiate tissue repair

2016

Dec. 05, 2016 - Congratulations to Jenna Harvestine for advancing to Ph.D. candidacy!

July 27, 2016 - Welcome Ben Hung to the Leach Lab!

June 09, 2016 - Congratulations to Kaitlin Murphy for successfully defending her Ph.D. thesis dissertation!

June 07, 2016 - Congratulations to Kaitlin Murphy for winning the 2016 BMEGG Outstanding Graduate Student Award!

May 19, 2016 - Congratulations to Debika Mitra for winning the award for Best Poster!

May 19, 2016 - Kaitlin Murphy, Steve Ho, Debika Mitra, and Jenna Harvestine presented their research at the 5th Annual BMEGG Research Day

May 04, 2016 - Congratulations to Debika Mitra and Kent Leach for winning the 2015-2016 Mentoring at Critical Transitions (MCT) fellowship award!

Jan. 01, 2016 - Welcome Jackie Whitehead to the Leach Lab!

2015

Nov. 01, 2015 - Congratulations to Steve Ho for advancing to Ph.D. candidacy.

Oct. 01, 2015 - Welcome Charlotte Vorwald to the Leach Lab!

July 20, 2015 - Leach Lab awarded a new R01 to study the role of biomaterials to instruct the function of entrapped cell spheroids!

July 10, 2015 - Congratulations to Steve Ho for being awarded a T32 Fellowship under the Animal Models of Infectious Diseases Training Program, funded by the National Institutes of Health!

July 01, 2015 - Kent Leach is promoted to Professor of Biomedical Engineering and Orthopaedic Surgery

June 01, 2015 - Congratulations to Allison Hoch for successfully defending her Ph.D. thesis dissertation!

April 01, 2015 - Congratulations to Jenna Harvestine for being awarded the National Defense Science and Engineering Graduate (NDSEG) Fellowship!

March 01, 2015 - Welcome Jenna Harvestine to the Leach Lab!

Feb 01, 2015 - News10 KXTV-ABC interviewed Kent Leach in Sacramento about how the new grant will benefit California patients.

Jan. 02, 2015 - Leach lab (in collaboration with Marcu and Athanasiou labs) was awarded a Tools and Technology Award from the California Institute for Regenerative Medicine to develop nondestructive methods to measure the maturation of engineered bone and cartilage!

2014

Dec. 20, 2014 - Congratulations to Kaitlin Murphy for winning an American Heart Association (AHA) Fellowship!

Dec. 14, 2014 - Debika Mitra presented an oral presentation at the 2014 TERMIS-AM Annual Meeting in Washington, D.C.

Nov. 01, 2014 - Congratulations to Beko Binder for successfully defending his Ph.D. thesis dissertation!

Oct. 23, 2014 - Congratulations to Debika Mitra for winning the 2014 BMES Reviewer's Choice Poster Award! Kaitlin Murphy and Beko Binder presented oral presentations, and Caroline Vissers also presented a poster at the 2014 BMES Annual Meeting in San Antonio, TX.

Sep. 01, 2014 - Congratulations to Debika Mitra for advancing to Ph.D. candidacy!

Sep. 01, 2014 - Congratulations to Debika Mitra for winning a California Institute for Regenerative Medicine (CIRM) Fellowship!

Aug. 01, 2014 - Caroline Vissers presented her research at IEEE Engineering in Medicine and Biology Conference in Chicago, IL, and the Beckman Symposium in Irvine, CA.

July 01, 2014 - Allison Hoch began her six-month co-op at Genentech in Early Stage Cell Culture

June 01, 2014 - Caroline Vissers was awarded the Departmental Citation Award for True Distinction in the Major!

June 01, 2014 - Kent Leach won the 2014 Outstanding Faculty Teaching Award!

May 20, 2014 - Kaitlin Murphy, Debika Mitra, and Allison Hoch presented their research at the 3rd Annual BMEGG Research Day

May 01, 2014 - Caroline Vissers was awarded the Chancellor’s Award for Excellence in Undergraduate Research!

May 01, 2014 - Congratulations to Beko Binder for winning the 2014 BMEGG Outstanding Graduate Student award!

April 01, 2014 - Allison Hoch presented an oral presentation, and Debika Mitra presented a poster at the Annual UC Davis Interdisciplinary Graduate and Professional Symposium (IGPS) in Davis, CA.

April 01, 2014 - Allison Hoch presented an oral presentation, and Debika Mitra presented a poster at the 23rd Annual UC Davis Biotechnology Retreat in Napa, CA.

April 01, 2014 - Congratulations to Beko Binder for winning a Floyd and Mary Schwall Dissertation Year Fellowship for 2014-2015!

March 01, 2014 - Congratulations to Allison Hoch for winning an Achievement Rewards for College Scientists (ARCS) scholarship for 2014-2015!

March 01, 2014 - Congratulations to Allison Hoch for winning the UC Davis Biotechnology fellowship for 2014-2015!

March 01, 2014 - Allison Hoch and Beko Binder presented rapid-fire presentations and posters at the 4th International Conference on Stem Cell Engineering (ICSCE) in Coronado, CA

Feb. 01, 2014 - The Leach lab welcomes a new post-doctoral researcher, Nina Vollmer, Ph.D.!  Nina received her Ph.D. in Materials Science, Colorado School of Mines, Golden, Colorado

2013

Dec. 01, 2013 - Congratulations to Miles Wilkinson for receiving his MS!

Nov. 01, 2013 - Congratulations to Kaitlin Murphy for advancing to Ph.D. candidacy!

Sep. 27, 2013 - Beko Binder presented an oral presentation, and Allison Hoch presented a poster at BMES in Seattle, WA.

June 01, 2013 - Hillary Davis, MD, Ph.D., received the Loren D. Carlson Student Research Award from the UC Davis School of Medicine!

June 01, 2013 - Vaishali Mittal was recognized for her efforts with the 2013 Outstanding Undergraduate Researcher Award for the Department of Biomedical Engineering!

May 01, 2013 - Allie has been awarded a UC Davis Biotechnology Training Program fellowship and an Achievement Rewards for College Scientists (ARCS) Scholarship!

May 01, 2013 - Samir Batarni has been selected to participate in the Biology Scholars Advanced Research Program (BSHARP) for 2013 and 2014!

May 01, 2013 - Caroline Vissers has been selected as a Beckman Scholar for 2013-2014!

May 01, 2013 - Sophia Fang presented her research at the Mayo Clinic through the CTSC Training Program

May 01, 2013 - Ganesh Ingavle has been named a Marie Curie Research Fellow to conduct research at the University of Brighton, starting in Fall 2013!

2012

May 20, 2012 - Congratulations to Beko Binder for winning Honorable Mention in Best Oral Presentation and Allison Hoch for winning the Best Poster Presentation at the 1st annual UC Davis Biomedical Engineering Graduate Group Research Conference!

May 01, 2012 - Congratulations to Allison Hoch for advancing to Ph.D. candidacy!

April 01, 2012 - Congratulations to Steve Ho for winning a 2012 Whitaker International Fellowship! Steve will be going to Zurich, Switzerland, at ETHZ (Swiss Federal Institute of Technology Zurich) next summer to work in the Skeletal Tissue Engineering Group at the Institute of Biomechanics under Professor Ralph Müller and Professor Sandra Hofmann.

2011

Dec. 01, 2011 - Congratulations to Martin Decaris for successfully defending his Ph.D. thesis dissertation!

Oct. 13, 2011 - Archana Bhat, Allison Hoch, Martin Decaris, and Kent Leach present at BMES 2011. A poster titled "Extracellular Matrix-coated Microbeads Deployed in Alginate Hydrogels for Bone Formation" was presented.

Sep. 20, 2011 - Congratulations to Kent Leach for being appointed Chair of the Biomedical Engineering Graduate Group for the next three years!

Sep. 01, 2011 - Congratulations to Beko Binder for earning a California Institute for Regenerative Medicine (CIRM) Fellowship!

Aug. 01, 2011 - Congratulations to Diana Morales-Hernández for completing her Masters!

April 01, 2011 - Congratulations to Allison Hoch for earning a Whitaker International Fellowship! Allison will perform research at the University Hospital Basel, Switzerland, with Professor Ivan Martin for one year.

March 01, 2011 - Congratulations to Hillary Davis for successfully defending her dissertation! Hillary has one degree down during her Physician Scientist Training Program training. Way to go!

Feb. 01, 2011- Kent Leach is interviewed for a UC Davis PBS Spotlight video: Making stem cells stick to business, and the Leach lab gets some airtime!

Jan. 01, 2011 - Congratulations to Hillary Davis for authoring the #1 most downloaded article in the Annals of Biomedical Engineering for the last 30 days!

2010

Oct. 01, 2010 - Congratulations to Jiawei He for successfully defending his dissertation! Jiawei is the first Ph.D. student to graduate from the Leach lab!

June 17, 2010 - Kent received a CDMRP Hypothesis Development Award from the U.S. Army!

June 01, 2010 - Congratulations to Chris Horner for winning the 2010 Department of Biomedical Engineering Outstanding Undergraduate Researcher Award!