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    Saiz Lab

The Saiz Laboratory primarily investigates the broad domains of fracture healing. Specifically, the lab focuses on the fracture healing response in the setting of polytrauma. We aim to define mechanistic cellular and molecular pathways involved in the physiologic response to trauma and fracture healing with a goal of identifying potential therapeutic targets. Additionally, we perform clinical and translational research given our direct clinical access. All our studies have specific clinical motivations and translational goals to advance the field of orthopaedic trauma care.

Augustine Saiz, M.D., was born and raised in Wisconsin and received his Bachelor of Science from the University of Wisconsin – Eau Claire with summa cum laude. He then attended the University of Wisconsin School of Medicine and Public Health, obtaining his medical degree with a Path of Distinction in Public Health. He completed his orthopaedic surgery residency with a year of research at UC Davis Health and received numerous awards during his residency years. His passion for orthopaedic traumatology led him to pursue a fellowship at UT Houston in Texas. Dr. Saiz’s contributions and recognition in the field of orthopaedic surgery have allowed him to participate in many national and international activities. He has been actively involved in AO Trauma North America and was selected for the prestigious AO John Border Memorial Fellowship and studied with Christoph Sommer in Chur where modern fracture surgery was developed. Dr. Saiz’s research interests include both clinical and basic science studies. Clinically, he is interested in surgical techniques, patient outcomes, and advancing treatment methods and protocols. Mechanistically, his lab investigates the systemic and local effects of polytrauma on fracture repair and the role of muscle injury on bone regeneration with the clinical goal of improving fracture healing. His research has resulted in numerous publications and national/international presentations. In addition, he serves on professional committees for the AO, AAOS, and the OTA Research Committee.

Systemic and Local Inflammatory Effects of Polytrauma on Fracture Healing
The Role of Senescence in Delayed Fracture Healing Following Polytrauma
Clinical Risk Factors and Predictive Biomarkers of Impaired Fracture Healing in Human Polytrauma Patients
Effects of Immunomodulation in Polytrauma on Fracture Repair

The Therapeutic Use of Mesenchymal Stem/Stromal Cells for Fracture Repair

One AO Abstract Award Finalist 2023
ORS ISFR Poster Award Finalist 2023
OTA Fellows Graduation Best Abstract Presentation 2022
ON/ICORS Education Scholarship 2022
OTA Research Grants Library Inclusion 2022
AO Trauma North America Young Investigator Award 2021
ORS ISFR Young Investigator 2021 3-Minute Thesis Finalist 2021
AO John Border Memorial Fellowship 2021
ASSH Linscheid-Dobyns Excellence in Wrist Research Award 2020
OTA Kathy Cramer Young Clinician Scholarship 2020
ORS 2020 Clinician Scholar Career Development Program 2020

COA Annual Meeting 2020 J. Harold LaBriola M.D. Award 2020

AO Trauma North America Fellow grant #171408-FEL2021, Saiz (PI) - October 2021 – 2023
Understanding the Mechanical Environment of Fracture Healing in the Human - AO Trauma North America Resident Research grant #171407, Saiz (PI) - September 2020 – 2021
Biomechanical Analysis of a Modified Triangular Osteosynthesis Technique for Treatment of Spinopelvic Dissociation
OTA Resident Research grant #1680, Saiz (PI) - January 2017 – 2018
Engineered Approaches for Muscle Repair to Promote Concurrent Bone Regeneration
Maryam Rahmati, Ph.D., Postdoctoral Fellow
Hannah Day, M.D., Orthopaedic surgery resident
Tony Baldini, Medical student
Renato Reyes, Undergraduate student
Jane Burgan

Click here to find a complete list of publications.


  • Gonzalez-Fernandez T, Tenorio AJ, Saiz AM Jr, Leach JK. Engineered Cell-Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of Mineralized Tissues. Adv Healthc Mater. 2022. PMID: 34968011


  • Saiz AM, Shieh AK, Hideshima K, Wong F, Klineberg EO, Eastman JG. Modified Lumbopelvic Fixation Technique Utilizing S1 Pedicle Screws for Spinopelvic Dissociation U-and H-Type Sacral Fractures with Kyphotic Deformity. Journal of Orthopaedic Trauma. 2021. PMID: 34510126
  • Rahmati M, Stötzel S, Khassawna TE, Iskhahova K, Florian Wieland DC, Zeller Plumhoff B, Haugen HJ. Early osteoimmunomodulatory effects of magnesium-calcium-zinc alloys. J Tissue Eng. 2021 PMID: 34589198


  • Saiz Jr AM, Gionet-Gonzales M, Lee MA, Leach JK. Conditioning of myoblast secretome using mesenchymal stem/stromal cell spheroids improves bone repair. Bone. 2019. PMID: 31102712