Charles S. DeCarli, M.D.
- Director of Alzheimer's Disease Center
Philosophy of Care
I believe in providing compassionate, person-centered to patients with Alzheimer's disease and their caregivers. This philosophy prioritizes the needs of the individual and respects their individual beliefs and values, along with the beliefs and values of those who support them.
Dr. DeCarli is the director of UC Davis Health's Alzheimer’s Disease Center, a National Institutes of Health-funded Alzheimer’s research center. He is also Director of the Imaging of Dementia and Aging (IDeA) laboratory.
His clinical care focuses on the diagnosis and initial management of individuals with mild cognitive impairment and dementia.
Dr. DeCarli's research focuses on using advanced structural and functional brain imaging to study normal aging, mild cognitive impairment, and dementia, and the role of genetics, cerebrovascular disease and Alzheimer's disease on these processes.
Dr. DeCarli is one of the champions of the Healthy Brain Aging Initiative, which seeks to advance novel approaches to optimize brain health from birth.
M.D., George Washington University, Washington, D.C., 1982
B.S., UC Santa Barbara, Santa Barbara, California, 1978
George Washington University Medical Center, Washington, District of Columbia, 1982-84
Strong Memorial Hospital, Rochester, New York, 1984-87
National Institute on Aging, Bethesda, Maryland, 1987-89
American Board of Neurology and Psychiatry, 1990
American Medical EEG Association - Electroencephalography,
Alzheimer's Disease Association, Neuroimaging Work Group
Alzheimer's Imaging Consortium
American Academy of Neurology
American Association for the Advancement of Science
American Heart Association
International Society for Vascular Behavioral and Cognitive Disorders
Society for Neuroscience
Honors and Awards
UC Davis School of Medicine Research Award, 2018,
A Sacramento Best Doctor, 2015,
Resident Education Teaching Award, “Excellence in Inpatient Teaching”, UC Davis Department of Neurology, 2014,
Victor and Genevieve Orsi Chair in Alzheimer’s Research, 2012,
Mayo Clinic Visiting Professor, 2012,
J. Allyn Taylor International Prize in Medicine—Imaging of the Aging Brain, 2010,
Dean’s Excellence in Research Mentoring Award, 2008,
Outstanding Teacher of the Year, UC Davis Department of Neurology, 2004,
Select Recent Publications
Nakanishi K, Jin Z, Homma S, Elkind MSV, Rundek T, Lee SC, Tugcu A, Yoshita M, DeCarli C, Wright CB, Sacco RL, Di Tullio MR. Association Between Heart Rate and Subclinical Cerebrovascular Disease in the Elderly. Stroke. 2018 Feb;49(2):319-324. doi: 10.1161/STROKEAHA.117.019355. Epub 2017 Dec 28.
Fletcher E, Gavett B, Harvey D, Farias ST, Olichney J, Beckett L, DeCarli C, Mungas D. Brain volume change and cognitive trajectories in aging. Neuropsychology. 2018 Mar 1. doi: 10.1037/neu0000447
Gavett BE, Fletcher E, Harvey D, Farias ST, Olichney J, Beckett L, DeCarli C, Mungas D. Ethnoracial differences in brain structure change and cognitive change. Neuropsychology. 2018 Apr 12. doi: 10.1037/neu0000452
Sarnowski C, Satizabal CL, DeCarli C, Pitsillides AN, Cupples LA, Vasan RS, Wilson JG, Bis JC, Fornage M, Beiser AS, DeStefano AL, Dupuis J, Seshadri S; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Neurocognitive Working Group. Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology. 2017 Dec 27. pii: 10.1212/WNL.0000000000004820. doi: 10.1212/WNL.0000000000004820
Dadar M, Maranzano J, Ducharme S, Carmichael OT, Decarli C, Collins DL; Alzheimer's Disease Neuroimaging Initiative. Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging. Hum Brain Mapp. 2017 Nov 27. doi: 10.1002/hbm.23894.
Weinstein G, Zelber-Sagi S, Preis SR, Beiser AS, DeCarli C, Speliotes EK, Satizabal CL, Vasan RS, Seshadri S. Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-Aged Adults in the Framingham Study. JAMA Neurol. 2017 Nov 20. doi: 10.1001/jamaneurol.2017.3229
McGrath ER, Beiser AS, DeCarli C, Plourde KL, Vasan RS, Greenberg SM, Seshadri S. Blood pressure from mid- to late life and risk of incident dementia. Neurology. 2017 Nov 8. pii: 10.1212/WNL.0000000000004741. doi: 10.1212/WNL.0000000000004741
Wright CB, Dong C, Perez EJ, De Rosa J, Yoshita M, Rundek T, DeCarli C, Gutierrez J, Elkind MSV, Sacco RL. Subclinical Cerebrovascular Disease Increases the Risk of Incident Stroke and Mortality: The Northern Manhattan Study. J Am Heart Assoc. 2017 Aug 28;6(9). pii: e004069. doi: 10.1161/JAHA.116.004069
Harawa NT, Manson SM, Mangione CM, Penner LA, Norris KC, DeCarli C, Scarinci IC, Zissimopoulos J, Buchwald DS, Hinton L, Pérez-Stable EJ. Strategies for enhancing research in aging health disparities by mentoring diverse investigators. J Clin Transl Sci. 2017 Jun;1(3):167-175. doi: 10.1017/cts.2016.23. Epub 2017 Feb 23
Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, Mitchell GF. Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults. J Am Heart Assoc. 2017 Aug 17;6(8). pii: e006206. doi: 10.1161/JAHA.117.006206