Katherine Rauen, M.D., Ph.D.

Katherine Rauen, M.D., Ph.D.

Specialties

Genomics

Genetics

RASopathies

Department

Pediatrics

Title

  • Chief, Division of Genomic Medicine
  • Professor, Department of Pediatrics
  • Albert Holmes Rowe Endowed Chair in Human Genetics II

Reviews

To see if Katherine Rauen is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis MIND Institute

2825 50th St.
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Phone: 916-703-0300
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Clinical Interests

Dr. Raun is the attending for both the Biochemical Genetics and Dysmorphology services for UC Davis Health and also supervises medical genetics fellows, rotation residents and medical students. In addition, Dr. Rauen covers consult servicesfor Mercy San Juan and Methodist hospitals while on service and also attends at UC Davis MIND Institute Massie Family Clinic.

Dr. Rauen launched the UC Davis NF/Ras Pathway Clinic to provide a multidisciplinary approach to the diagnosis and care of individuals with RASopathies [Neurofibromatosis types 1 and 2, Noonan/LEOPARD, CFC, Costello, Legius syndromes and others], or individuals with a phenotype which is suggestive of a diagnosis in this pathway. 

Research/Academic Interests

Dr. Rauen's research focuses on Array CGH, Cardio-Facio-Cutaneous Syndrome, Cancer Genomics, Cancer Syndromes, Clinical Trials, Costello Syndrome, Constitutional Chromosome Aberrations, Cytogenetics, Congenital Abnormalities, Genetic Medicine, Medical Education, Mouse Models, Myogenesis, Myopathy, Neurofibromatosis 1, Noonan Syndrome, Prenatal Genetics, RASopathy, Ras/MAPK Pathway, Small Molecule Inhibitors and Signal Transduction.

Division

Genomic Medicine

Center/Program Affiliation

UC Davis Children's Hospital
UC Davis MIND Institute
Genome Center

Education

M.D., UC Irvine College of Medicine, Irvine CA 1995

Ph.D., Genetics, UC Davis, Davis CA 1992

B.S., Biology, California State University, Bakersfield, Bakersfield CA 1981

M.S. Physiology, UC Davis, Davis CA 1985

Residency

Pediatrics, UC San Francisco, San Francisco CA 1995-1997

Fellowships

Medical Genetics, UC San Francisco, San Francisco CA 1997-2000

Board Certifications

American Board of Medical Genetics,

American Board of Pediatrics,

Professional Memberships

American College of Medical Genetics and Genomics

American Society of Gene Therapy

American Society of Human Genetics

Association of Professors in Human and Medical Genetics

Society for Pediatric Research

Western Society for Pediatric Research

Honors and Awards

Sacramento Magazine Top Doctor, 2016, 2017, 2018, 2019

Costello Syndrome Family Network Award of Service, 2019

March of Dimes Service Award, 2017, 2018

Award of Service RASopahtiesNet, 2017

Global Genes RARE Champion of Hope � Science, 2014

UC Davis Albert Holmes Rowe Endowed Chair in Human Genetics II, 2014

Presidential Early Career Awards for Scientists and Engineers (2012), 2013

Costello Syndrome Family Network Recognition of 10 Years of Service, 2011

Award of Appreciation - Children�s Tumor Foundation, 2010

CFC International Award of Appreciation, 2010

Award of Recognition-UCSF Department of OB/Gyn and Reproductive Sciences, 2009

NF Inc Go the Extra Mile Award, 2009

CFC International Award of Service, 2007

Costello Syndrome Family Network Award of Dedication, 2007

CFC International Achievement Award for Gene Discovery, 2006

Select Recent Publications

Castel P, Rauen KA, McCormick F. The duality of human oncoproteins: drivers of cancer and congenital disorders. Nat Rev Cancer. 2020 Jul;20(7):383-397. doi:10.1038/s41568-020-0256-z. Epub 2020 Apr 27. PMID:32341551.

Gripp KW, Morse LA, Axelrad M, Chatfield KC, Chidekel A, Dobyns W, Doyle D, Kerr B, Lin AE, Schwartz DD, Sibbles BJ, Siegel D, Shankar SP, Stevenson DA, Thacker MM, Weaver KN, White SM, Rauen KA. Costello syndrome: Clinical phenotype, genotype, and management guidelines. Am J Med Genet A. 2019 Sep;179(9):1725-1744. doi:10.1002/ajmg.a.61270. Epub 2019 Jun 20. PMID:31222966.

Tidyman WE, Rauen KA. Pathogenetics of the RASopathies. Hum Mol Genet. 2016 Oct 1;25(R2):R123-R132. doi:10.1093/hmg/ddw191. Epub 2016 Jul 12. PMID:27412009.

Tidyman, WE, KA Rauen. Expansion of the RASopathies. Curr Genet Med Rep. 2016 Sep;4(3):57-64. doi:10.1007/s40142-016-0100-7. Epub 2016 Jul 1. PMID:27942422.

Adviento B, Corbin IL, Widjaja F, Desachy G, Enrique N, Rosser T, Risi S, Marco EJ, Hendren RL, Bearden CE, Rauen KA, Weiss LA. Autism traits in the RASopathies. J Med Genet. 2014 Jan;51(1):10-20. doi:10.1136/jmedgenet-2013-101951. Epub 2013 Oct 7. PMID:24101678.

Siegel DH, McKenzie J, Frieden IJ, Rauen KA. Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome. Br J Dermatol. 2011 Mar;164(3):521-9. doi:10.1111/j.1365-2133.2010.10122.x. Epub 2011 Jan 28. PMID:21062266.

Rauen KA, Tidyman WE, Estep AL, Sampath S, Peltier HM, Bale SJ, Lacassie Y. Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations. Am J Med Genet A. 2010 Apr;152A(4):807-14. doi:10.1002/ajmg.a.33342. PMID:20358587.

Pierpont ME, Magoulas PL, Adi S, Kavamura MI, Neri G, Noonan J, Pierpont EI, Reinker K, Roberts AE, Shankar S, Sullivan J, Wolford M, Conger B, Santa Cruz M, Rauen KA. Cardio-facio-cutaneous syndrome: clinical features, diagnosis, and management guidelines. Pediatrics. 2014 Oct;134(4):e1149-62. doi:10.1542/peds.2013-3189. Epub 2014 Sep 1. PMID:25180280.

Tidyman WE, Lee HS, Rauen KA. Skeletal muscle pathology in Costello and cardio-facio-cutaneous syndromes: developmental consequences of germline Ras/MAPK activation on myogenesis. Am J Med Genet C Semin Med Genet. 2011 May 15;157C(2):104-14. doi:10.1002/ajmg.c.30298. Epub 2011 Apr 14. PMID:21495178.

Rauen KA. The RASopathies. Annu Rev Genomics Hum Genet. 2013;14:355-69. doi:10.1146/annurev-genom-091212-153523. Epub 2013 Jul 15. PMID:23875798.