Tsung-Yu Chen, M.D., M.S., Ph.D.

Tsung-Yu Chen, M.D., M.S., Ph.D.






  • Professor




Center/Program Affiliation

Center for Neuroscience


M.D., National Yang-Ming Medical School, Taipei, 1986

Ph.D., Johns Hopkins University School of Medicine, Baltimore, Maryland, 1994

Internship: National Yang-Ming Medical School/Veteran General Hospital-Taipei, Taipei, 1984-86


Brandeis University, Ealtham, Massachusetts, 1994-96

Professional Memberships

Biophysical Society

Society for General Physiologists

Honors and Awards

Paul F. Cranefield Award, Society of General Physiologists, 2004

Michael A. Shanoff Research Award, Johns Hopkins University School of Medicine, 1994

Scholarship of Ministry of Education, Taiwan, 1989

Shun-Ro In Research Award, Yang-Ming Medical College, Taiwan., 1988

Select Recent Publications

Chen T-Y, Lin Y-F., and Zheng J. (2009) Electrophysiological Measurements of Membrane Proteins. In Handbook of Modern Biophysics, Vol 1 , T. Jue ed. pp 111-145. Humana Press. New York, NY

Zhang X.-D., and Chen T.-Y (2009) Amphiphilic blockers punch through a mutant CLC-0 pore. J Gen. Physiol. 133: 59-68.

Zhang X.-D., Tseng P.-Y, Yu W.-P., and Chen T.-Y (2009) Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J Gen. Physiol. 133: 43-58.

Zhang X.-D. Tseng P.-Y, and Chen T.-Y (2008) ATP inhibition of CLC-1 is controlled by oxidation and reduction. J Gen. Physiol. 132: 421-428.

Chen T.-Y, and Hwang, T.-C. (2008) CLC-0 and CFTR: Chloride channels evolved from transporters. Physiol. Rev. 88: 351-387.

Tseng P.-Y, Bennetts B., and Chen T.-Y (2007) Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH. J Gen. Physiol. 130: 217-221.

Chen, T.-Y, Takeuchi H, and Kurahashi T. (2006) Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. J Gen Physiol. 128: 365-371.

Zhang X.-D., Li Y, Yu W.-P. and Chen T.-Y (2006) Roles of K149, G352 and H401 in the channel functions of CIC-0: Testing the predictions from theoretical calculations. J Gen. Physiol. 127: 435-447.

Bykova E. A., Zhang X.-D., Chen T.-Y, and Zheng 1. (2006) Large movement in the C-terminus of CLC-0 chloride channel during slow gating. Nature Struct & Mol. Biol. 13: 1115-1119.

Chen T.-Y. (2005) Structure and function of ClC channels. Ann. Rev. Physiol. 67: 809-839.

Li Y, Yu W.-P., Lin C.-W. and Chen T.-Y. (2005) Oxidation and reduction control of the inactivation gating of Torpedo ClC-0 chloride channels. Biophys. J. 88: 3936-3945.