Jasper Yik, Ph.D.
Associate Project Scientist
Locations and Contact
Research/Academic Interests
Dr. Yik's research focuses on understanding the molecular mechanisms that drive osteoarthritis development, and developing new treatments through targeted inhibition of key regulators of inflammatory genes.
Division
Orthopaedic Surgery
Undergraduate School
B.S., University of Central Oklahoma, Edmond OK 1995
Other School
Ph.D., University of Oklahoma, Health Sciences Center, Oklahoma City OK 2002
Barboric M, Yik JH, Czudnochowski N, Yang Z, Chen R, Contreras X, Geyer M, Matija Peterlin B, Zhou Q. Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription. Nucleic Acids Res. 2007;35(6):2003-12. doi:10.1093/nar/gkm063. Epub 2007 Mar 6. PMID:17341462.
Zhou Q, Yik JH. The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol Mol Biol Rev. 2006 Sep;70(3):646-59. doi:10.1128/MMBR.00011-06. PMID:16959964.
Yang Z, Yik JH, Chen R, He N, Jang MK, Ozato K, Zhou Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell. 2005 Aug 19;19(4):535-45. doi:10.1016/j.molcel.2005.06.029. PMID:16109377.
Yik JH, Chen R, Pezda AC, Zhou Q. Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. J Biol Chem. 2005 Apr 22;280(16):16368-76. doi:10.1074/jbc.M500912200. Epub 2005 Feb 14. PMID:15713661.
Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q. A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. Mol Cell Biol. 2004 Jun;24(12):5094-105. doi:10.1128/MCB.24.12.5094-5105.2004. PMID:15169877.
Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q. Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol Cell. 2003 Oct;12(4):971-82. doi:10.1016/s1097-2765(03)00388-5. PMID:14580347.
Yik JH, Weigel PH. The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor. J Biol Chem. 2002 Dec 6;277(49):47305-12. doi:10.1074/jbc.M208751200. Epub 2002 Oct 4. PMID:12370180.
Yik JH, Saxena A, Weigel JA, Weigel PH. Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. J Biol Chem. 2002 Oct 25;277(43):40844-52. doi:10.1074/jbc.M204780200. Epub 2002 Aug 8. PMID:12171918.
Saxena A, Yik JH, Weigel PH. H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. J Biol Chem. 2002 Sep 20;277(38):35297-304. doi:10.1074/jbc.M205653200. Epub 2002 Jun 27. PMID:12089159.
Yik JH, Saxena A, Weigel PH. The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes. J Biol Chem. 2002 Jun 21;277(25):23076-83. doi:10.1074/jbc.M202748200. Epub 2002 Apr 9. PMID:11943787.