Dr. Wedgewood is interested in understanding why some babies born very premature are at increased risk of developing fatal diseases including pulmonary hypertension and bronchopulmonary dysplasia. Due to his research in rats has led him to investigate the effects of certain nutrients, probiotics and drugs in preventing or reversing these diseases. His studies may lead to improved treatments for premature babies.
Ph.D., University of Edinburgh, Edinburgh, UK, 1996
B.S., University of Edinburgh, Edinburgh, UK, 1991
Northwestern University, Evanston, IL, 2001
University of Leeds, United Kingdom, 1999
American Heart Association
American Thoracic Society
Society for Free Radical Biology and Medicine
Honors and Awards
Visiting Professor Nationwide Children�s Hospital, Columbus, Ohio, 2008
Children�s Memorial Hospital Seed Grant Award, 2003
Cancer Research Campaign (U.K.) Postdoctoral Research Fellow, 1999
BBSRC (U.K.) Postgraduate Trainee Award, 1996
British Council Exchange Scholarship, National Institute of Genetics, Japan, 1994
Select Recent Publications
Wedgwood S, Gerard K, Halloran K, Hanhauser A, Monacelli S, Warford C, Thai PN, Chiamvimonvat N, Lakshminrusimha S, Steinhorn RH, Underwood MA. Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis. Front Immunol. 2020;11:357. doi:10.3389/fimmu.2020.00357 PMID:32194566.
Wedgwood S, Warford C, Agvatisiri SR, Thai PN, Chiamvimonvat N, Kalanetra KM, Lakshminrusimha S, Steinhorn RH, Mills DA, Underwood MA. The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model. Pediatr Res. 2020;87:472-479. PMID:31537010.
La Frano M, Fahrmann J, Grapov D, Pedersen T, Newman JW, Fiehn O, Underwood MA, Mestan KK, Steinhorn R, Wedgwood S. Umbilical Cord Blood Metabolomics Reveal Distinct Signatures of Dyslipidemia Prior to Bronchopulmonary Dysplasia and Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2018;315:L870-L881. PMID:30113229.
La Frano R, Fahrmann J, Grapov D, Fiehn O, Pedersen T, Newman J, Underwood M, Steinhorn R, Wedgwood S. Metabolic Perturbations of Postnatal Growth Restriction and Hyperoxia-Induced Pulmonary Hypertension in a Bronchopulmonary Dysplasia Model. Metabolomics. 2017;13:32.
Wedgwood S, Warford C, Agvateesiri SC, Thai P, Berkelhamer SK, Perez M, Underwood MA, Steinhorn RH. Postnatal growth restriction augments oxygen-induced pulmonary hypertension in a neonatal rat model of bronchopulmonary dysplasia. Pediatr Res. 2016;80:894-902. PMID:7509009.
Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L196-L203. PMID:26024892.
Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn. Front Pharmacol. 2015;6:47. PMID:25814954.
Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. Brief Hyperoxia Increases Mitochondrial Oxidation and Increases PDE5 Activity in Fetal Pulmonary Artery Smooth Muscle Cells. Antioxid Redox Signal. 2012;17:460-470.
Wedgwood S, Lakshminrusimha S, Farrow KN, Czech L, Gugino SF, Soares F, Russell JA, Steinhorn RH. Apocynin Improves Oxygenation and Increases eNOS in Persistent Pulmonary Hypertension of the Newborn. Am J Physiol Lung Cell Mol Physiol. 2012;302:L616-L626.
Perez M, Lakshminrusimha S, Wedgwood S, Czech L, Gugino SF, Russell JA, Farrow KN, Steinhorn RH. Hydrocortisone Normalizes Oxygenation and cGMP Regulation in Lambs with Persistent Pulmonary Hypertension of the Newborn. Am J Physiol Lung Cell Mol Physiol. 2012;302:L595-L603.