Stephen Wedgwood, Ph.D.

Stephen Wedgwood, Ph.D.

Specialties

Neonatology

Department

Pediatrics

Title

  • Associate Researcher

Reviews

UC Davis Children's Hospital

2315 Stockton Blvd.
Sacramento, CA 95817
Driving Directions

Primary Phone:
800-282-3284

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Clinical Interests

Dr. Wedgewood is interested in understanding why some babies born very premature are at increased risk of developing fatal diseases including pulmonary hypertension and bronchopulmonary dysplasia. Due to his research in rats has led him to investigate the effects of certain nutrients, probiotics and drugs in preventing or reversing these diseases. His studies may lead to improved treatments for premature babies.

Division

Neonatology

Center/Program Affiliation

UC Davis Children's Hospital

Education

Ph.D., University of Edinburgh, Edinburgh, UK, 1996

B.S., University of Edinburgh, Edinburgh, UK, 1991

Fellowships

Northwestern University, Evanston, IL, 2001

University of Leeds, United Kingdom, 1999

Professional Memberships

American Heart Association

American Thoracic Society

Society for Free Radical Biology and Medicine

Honors and Awards

Visiting Professor Nationwide Children�s Hospital, Columbus, Ohio, 2008

Children�s Memorial Hospital Seed Grant Award, 2003

Cancer Research Campaign (U.K.) Postdoctoral Research Fellow, 1999

BBSRC (U.K.) Postgraduate Trainee Award, 1996

British Council Exchange Scholarship, National Institute of Genetics, Japan, 1994

Select Recent Publications

Wedgwood S, Gerard K, Halloran K, Hanhauser A, Monacelli S, Warford C, Thai PN, Chiamvimonvat N, Lakshminrusimha S, Steinhorn RH, Underwood MA. Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis. Front Immunol. 2020;11:357. doi:10.3389/fimmu.2020.00357 PMID:32194566.

Wedgwood S, Warford C, Agvatisiri SR, Thai PN, Chiamvimonvat N, Kalanetra KM, Lakshminrusimha S, Steinhorn RH, Mills DA, Underwood MA. The developing gut-lung axis: postnatal growth restriction, intestinal dysbiosis, and pulmonary hypertension in a rodent model. Pediatr Res. 2020;87:472-479. PMID:31537010.

La Frano M, Fahrmann J, Grapov D, Pedersen T, Newman JW, Fiehn O, Underwood MA, Mestan KK, Steinhorn R, Wedgwood S.  Umbilical Cord Blood Metabolomics Reveal Distinct Signatures of Dyslipidemia Prior to Bronchopulmonary Dysplasia and Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2018;315:L870-L881. PMID:30113229.

La Frano R, Fahrmann J, Grapov D, Fiehn O, Pedersen T, Newman J, Underwood M, Steinhorn R, Wedgwood S. Metabolic Perturbations of Postnatal Growth Restriction and Hyperoxia-Induced Pulmonary Hypertension in a Bronchopulmonary Dysplasia Model. Metabolomics. 2017;13:32.

Wedgwood S, Warford C, Agvateesiri SC, Thai P, Berkelhamer SK, Perez M, Underwood MA, Steinhorn RH. Postnatal growth restriction augments oxygen-induced pulmonary hypertension in a neonatal rat model of bronchopulmonary dysplasia. Pediatr Res. 2016;80:894-902. PMID:7509009.

Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L196-L203. PMID:26024892.

Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn. Front Pharmacol. 2015;6:47. PMID:25814954.

Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. Brief Hyperoxia Increases Mitochondrial Oxidation and Increases PDE5 Activity in Fetal Pulmonary Artery Smooth Muscle Cells. Antioxid Redox Signal. 2012;17:460-470.

Wedgwood S, Lakshminrusimha S, Farrow KN, Czech L, Gugino SF, Soares F, Russell JA, Steinhorn RH. Apocynin Improves Oxygenation and Increases eNOS in Persistent Pulmonary Hypertension of the Newborn. Am J Physiol Lung Cell Mol Physiol. 2012;302:L616-L626.

Perez M, Lakshminrusimha S, Wedgwood S, Czech L, Gugino SF, Russell JA, Farrow KN, Steinhorn RH. Hydrocortisone Normalizes Oxygenation and cGMP Regulation in Lambs with Persistent Pulmonary Hypertension of the Newborn. Am J Physiol Lung Cell Mol Physiol. 2012;302:L595-L603.