Ian Brown, M.D., Ph.D.

Ian Elliott Brown, M.D., Ph.D.


  • Assistant Professor


To see if Ian Elliott Brown is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis Medical Center

2315 Stockton Blvd.
Sacramento, CA 95817
Driving Directions

Primary Phone:
800-2-UCDAVIS (800-282-3284)

Additional Phone Numbers

Phone: 916-734-2680
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

In the setting of severe injury, tissue injury occurs not only as a direct result of the traumatic insult, but also as a result of a patient's own inflammatory responses. These responses are often beneficial and appropriate in some settings but can potentially become maladaptive in the setting of severe injury. An understanding of these responses may help us to effectively mitigate some of the maladaptive consequences of these responses in appropriate situations. We examine the nature of inflammatory responses initiated by the inflammation/coagulation axis during severe injury. 


General Surgery
Division of Trauma, Acute Care Surgery and Surgical Critical Care


M.D., University of Chicago, Pritzker School of Medicine, Chicago IL 2007

Ph.D., Immunology, University of Chicago, Chicago IL 2005

B.S., Stanford University, Palo Alto CA 1997

Internship: General Surgery, UC San Francisco Medical Center, San Francisco CA 2007-2008


General Surgery, UC San Francisco Medical Center, San Francisco CA 2007-2014


Trauma and Surgical Critical Care, UC Davis Medical Center, Sacramento CA 2014-2015

Honors and Awards

UCSF Azakie-Chesson Award for Compassion in Surgery, 2014

Select Recent Publications

Brown I, Bellevue O, Shawo A, Woldesemayat H, Lyo V, Rayikanti B, Lee M, Uzosike E, Kasravi S, Harris HW. Low dose cyclophosphamide improves survival in a murine treatment model of sepsis. Shock. 2015 Jan;43(1):92-8. 

Kline J, Brown I, Zha Y, Blank C, Strickler C, Wouters H, Zhang L, Gajewski, TF. Homeostatic  proliferation plus regulatory T cell depletion promotes potent rejection of B16 melanoma.  Clinical Cancer Research, 2008 May 15;14(10):3156-67

Zha Y, Marks R, Ho AW, Peterson AC, Janardhan S, Brown I, Praveen K, Stang S, Stone JC, Gajewski TF. T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase. Nature Immunology, 2006 Nov;7(11):1166-73.

Brown IE, Blank C, Kline J, Kacha AK, Gajewski TF. Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. Journal of Immunology, 2006 Oct 1 177: (7):4521-9.

Velicu S, Han Y, Ulasov I, Brown IE, Andaloussi AE, Gajewski TF, Lesniak MS. Cross- priming of T cells  to intracranial tumor antigens elicits an immune response that fails in the effector phase but can  be augmented with local immunotherapy. Journal of Neuroimmunology. 2006 May;174(1-2):74- 81.