Marie Burns, Ph.D.

Marie E. Burns, Ph.D.

Specialties

Ophthalmology

Title

  • Professor

Reviews

Clinical Interests

Trained as a biochemist and electrophysiologist, Marie E. Burns studies the temporal regulation of signal transduction mechanisms in neurons. Much of her work has investigated the deactivation of the G protein cascade in photoreceptor cells of the retina. Her future studies will seek to understand the mechanisms by which different G protein cascades yield signals of varying amplitude and durations, such as in the rod and cone photoreceptors in the retina.

Division

Ophthalmology

Center/Program Affiliation

Center for Neuroscience
Eye Center

Education

Ph.D., Neurobiology and Cell & Molecular Biology, Duke University, Durham NC 1996

M.S., Neurobiology, Duke University, Durham NC 1994

B.S., Susquehanna University, Selinsgrove PA 1992

Fellowships

Neurobiology, Stanford University, Palo Alto CA 1996-2000

Professional Memberships

American Society for Cell Biology

Association for Research in Vision and Ophthalmology

Association for the Advancement of Science

Biophysical Society

MBL Society

Society for Neuroscience

Honors and Awards

Faculty Service Award, Neuroscience Graduate Group, 2015

Outstanding Graduate Mentor in Neuroscience, UC Davis Neuroscience Graduate Students, 2013

Valedictorian, Susquehanna University, Selinsgrove, PA,

E. Matilda Ziegler Foundation for the Blind Award,

Alfred P. Sloan Research Fellow,

Cogan Award, Association for Research in Vision and Ophthalmology,

Kavli Fellow, National Academy of Sciences,

Alumni Achievement Award, Susquehanna University,

Outstanding Graduate Mentor in Neuroscience, UC Davis Neuroscience Graduate Students,

Faculty Service Award, Neuroscience Graduate Group,

Faculty of 1000, Sensory Systems, Biology,

Select Recent Publications

Ronning, K.E., Karlen, S.J., Miller, E.B. and Burns, M.E. (2019). Molecular profiling of immune cells during retinal degeneration using single-cell sequencing. Scientific Reports (in press).

Karlen, S.J., Miller, E.B., Wang, X., Levine, E.S., Zhang, P., Goswami, M., Zawadzki, R.J., Pugh, Jr. E.N., and Burns, M.E. (2018). Monocyte infiltration rather than microglia proliferation dominates the early immune response to widespread photoreceptor degeneration. J. Neuroinflammation 15, 344.

Ronning, K.E., Peinado Allina, G., Miller, E.B., Goswami, M., Zawadzki, R.J., Pugh, Jr. E.N., Herrmann, R. and Burns, M.E. (2018). Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Exp. Eye Res. 171, 111-118.

Wang, X., Miller, E.B., Goswami, M., Zhang, P., Ronning, K. E., Karlen, S.J., Zawadzki, R.J., Pugh, Jr. E.N., and Burns, M.E. (2017). Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130.  J. Neuroinflammation 14, 121.

Peinado Allina, G. Fortenbach, C.F., Naarendorp, F., Gross, O.P., Pugh, Jr. E.N., Burns, M.E. (2017). Bright flash response recovery of mammalian rods in vivo is rate-limited by RGS9.  J. Gen. Physiol.  149, 443-454. 

Gross, O.P., Pugh, E.N., Jr., and Burns, M.E. (2015).  cGMP in mouse rods:  the spatiotemporal dynamics underlying single photon responses.  Front Mol Neurosci, 8, 6. doi: 10.3389/fnmol.2015.00006. eCollection 2015. PMID: 25788876.

Gross, O.P., Pugh, Jr. E.N. and Burns, M.E. (2012). Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.  Neuron 76, 370-382.

Gross, O.P., Pugh, Jr. E.N. and Burns, M.E. (2012).  Spatiotemporal cGMP dynamics in living mouse rods.  Biophys. J. 102, 1775-1784.

Fortenbach, C.F. Peinado, G., Kessler, C. and Burns, M.E. (2015). Speeding rod recovery improves temporal resolution in the retina.  Vision Res, 110, 57-67. PMID: 25748270.

Levine, E.S., Zam, A., Zhang, P., Pechko, A., Wang, X., FitzGerald, P., Pugh, Jr., E.N., Zawadzki, R. and Burns, M.E.  (2014). Rapid light-induced migration of retinal microglia in mice lacking Arrestin-1.  Vision Res, 102, 71-9.