Trained as a biochemist and electrophysiologist, Marie E. Burns studies the temporal regulation of signal transduction mechanisms in neurons. Much of her work has investigated the deactivation of the G protein cascade in photoreceptor cells of the retina. Her future studies will seek to understand the mechanisms by which different G protein cascades yield signals of varying amplitude and durations, such as in the rod and cone photoreceptors in the retina.
Ph.D., Neurobiology and Cell & Molecular Biology, Duke University, Durham NC 1996
M.S., Neurobiology, Duke University, Durham NC 1994
B.S., Susquehanna University, Selinsgrove PA 1992
Neurobiology, Stanford University, Palo Alto CA 1996-2000
American Society for Cell Biology
Association for Research in Vision and Ophthalmology
Association for the Advancement of Science
Society for Neuroscience
Honors and Awards
Faculty Service Award, Neuroscience Graduate Group, 2015
Outstanding Graduate Mentor in Neuroscience, UC Davis Neuroscience Graduate Students, 2013
Valedictorian, Susquehanna University, Selinsgrove, PA,
E. Matilda Ziegler Foundation for the Blind Award,
Alfred P. Sloan Research Fellow,
Cogan Award, Association for Research in Vision and Ophthalmology,
Kavli Fellow, National Academy of Sciences,
Alumni Achievement Award, Susquehanna University,
Outstanding Graduate Mentor in Neuroscience, UC Davis Neuroscience Graduate Students,
Faculty Service Award, Neuroscience Graduate Group,
Faculty of 1000, Sensory Systems, Biology,
Select Recent Publications
Ronning, K.E., Karlen, S.J., Miller, E.B. and Burns, M.E. (2019). Molecular profiling of immune cells during retinal degeneration using single-cell sequencing. Scientific Reports (in press).
Karlen, S.J., Miller, E.B., Wang, X., Levine, E.S., Zhang, P., Goswami, M., Zawadzki, R.J., Pugh, Jr. E.N., and Burns, M.E. (2018). Monocyte infiltration rather than microglia proliferation dominates the early immune response to widespread photoreceptor degeneration. J. Neuroinflammation 15, 344.
Ronning, K.E., Peinado Allina, G., Miller, E.B., Goswami, M., Zawadzki, R.J., Pugh, Jr. E.N., Herrmann, R. and Burns, M.E. (2018). Loss of cone function without degeneration in a novel Gnat2 knock-out mouse. Exp. Eye Res. 171, 111-118.
Wang, X., Miller, E.B., Goswami, M., Zhang, P., Ronning, K. E., Karlen, S.J., Zawadzki, R.J., Pugh, Jr. E.N., and Burns, M.E. (2017). Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. J. Neuroinflammation 14, 121.
Peinado Allina, G. Fortenbach, C.F., Naarendorp, F., Gross, O.P., Pugh, Jr. E.N., Burns, M.E. (2017). Bright flash response recovery of mammalian rods in vivo is rate-limited by RGS9. J. Gen. Physiol. 149, 443-454.
Gross, O.P., Pugh, E.N., Jr., and Burns, M.E. (2015). cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. Front Mol Neurosci, 8, 6. doi: 10.3389/fnmol.2015.00006. eCollection 2015. PMID: 25788876.
Gross, O.P., Pugh, Jr. E.N. and Burns, M.E. (2012). Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes. Neuron 76, 370-382.
Gross, O.P., Pugh, Jr. E.N. and Burns, M.E. (2012). Spatiotemporal cGMP dynamics in living mouse rods. Biophys. J. 102, 1775-1784.
Fortenbach, C.F. Peinado, G., Kessler, C. and Burns, M.E. (2015). Speeding rod recovery improves temporal resolution in the retina. Vision Res, 110, 57-67. PMID: 25748270.
Levine, E.S., Zam, A., Zhang, P., Pechko, A., Wang, X., FitzGerald, P., Pugh, Jr., E.N., Zawadzki, R. and Burns, M.E. (2014). Rapid light-induced migration of retinal microglia in mice lacking Arrestin-1. Vision Res, 102, 71-9.