Frank Sharp, M.D.

Frank R. Sharp, M.D.






  • Professor of Neurology


Research/Academic Interests

Frank Sharp's research focuses on molecular neurobiology, genomics, neural cell injury and cell death and the blood genomics of neurological disease. Prior to his appointment at UC Davis,

Sharp had a distinguished clinical and research career at UC San Diego, UC San Francisco and the University of Cincinnati, making groundbreaking contributions to new fields of study and new insights into brain function and disease.

Among these contributions were: first laboratory to show proof of principle for using blood genomics to detect pathological events in the animal and human brain, paved the way for performing PET and fMRI studies in humans, and first to demonstrate that a transcription factor can be used to map active neurons.

Sharp is currently on the editorial boards of several journals, has been a standing member of the AHA Brain grant review committee, and is a permanent member of the NINDS NSDA review Committee.



Center/Program Affiliation

UC Davis MIND Institute


M.D., UC San Diego, La Jolla CA 1972

Research Associate, National Institute of Mental Health, Bethesda MD 1973-1976

B.S., UC Davis, Davis CA 1968

Internship: Duke University Hospitals, Durham, North Carolina, 1972-1973


Neurology, UC San Francisco, San Francisco CA 1976-1979

Board Certifications

American Board of Neurology, 1981

Professional Memberships

Society for Cerebral Blood Flow and Metabolism

Society for Neurochemistry

Society for Neuroscience

Honors and Awards

Visiting Professor, University of Pennsylvania, UCSF, NYU, Emory University, Mount Sinai, 2012

Dean�s Prize, Excellence in Research at University of California at Davis, 2009

Select Recent Publications

Zhan X, Cox C, Ander BP, Liu D, Stamova B, Jin LW, Jickling GC, Sharp FR. Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. J Alzheimers Dis. 2015 May 30;46(2):507-23.

Zhan X, Jickling GC, Ander BP, Stamova B, Liu D, Kao PF, Zelin MA, Jin LW, DeCarli C, Sharp FR. Myelin basic protein associates with AβPP, Aβ1-42, and amyloid plaques in cortex of Alzheimer's disease brain. J Alzheimers Dis. 2015;44(4):1213-29.

Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One. 2014 Jul 18;9(7):e102550.

Bai Z, Stamova B, Xu H, Ander BP, Wang J, Jickling GC, Zhan X, Liu D, Han G, Jin LW, DeCarli C, Lei H, Sharp FR. Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities. Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):226-33.

Liu da Z, Sharp FR, Van KC, Ander BP, Ghiasvand R, Zhan X, Stamova B, Jickling GC, Lyeth BG. Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Jul 15;31(14):1268-76.

Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, Sharp FR. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow Metab. 2014 Feb;34(2):185-99.

Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Rothstein L, Verro P, Khoury J, Jauch EC, Pancioli AM, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Ann Neurol. 2013 Aug;74(2):232-40.

Jickling GC, Stamova B, Ander BP, Zhan X, Liu D, Sison SM, Verro P, Sharp FR. Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke. 2012 Aug;43(8):2036-41.

Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison SM, Verro P, Johnston SC, Sharp FR. Ischemic transient neurological events identified by immune response to cerebral ischemia. Stroke. 2012 Apr;43(4):1006-12.

Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab. 2012 May;32(5):780-91