Charles DeCarli, M.D.

Charles S. DeCarli, M.D.

Specialties

Alzheimer's Disease

Cognitive Neuroscience

Dementia

Department

Neurology

Title

  • Director of Alzheimer's Disease Research Center
  • Distinguished Professor, Department of Neurology

Reviews

To see if Charles S. DeCarli is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Lawrence J. Ellison Ambulatory Care Center

4860 Y Street, Suite 3900
Sacramento, CA 95817
Driving Directions

Primary Phone:
916-734-5496

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Philosophy of Care

I believe in providing compassionate, person-centered to patients with Alzheimer's disease and their caregivers. This philosophy prioritizes the needs of the individual and respects their individual beliefs and values, along with the beliefs and values of those who support them.  

Clinical Interests

Dr. DeCarli is the director of UC Davis Health's Alzheimer’s Disease Center, a National Institutes of Health-funded Alzheimer’s research center. He is also Director of the Imaging of Dementia and Aging (IDeA) laboratory.

His clinical care focuses on the diagnosis and initial management of individuals with mild cognitive impairment and dementia.

Research/Academic Interests

Dr. DeCarli's research focuses on using advanced structural and functional brain imaging to study normal aging, mild cognitive impairment, and dementia, and the role of genetics, cerebrovascular disease and Alzheimer's disease on these processes.

Dr. DeCarli is one of the champions of the Healthy Brain Aging Initiative, which seeks to advance novel approaches to optimize brain health from birth.

Division

Neurology

Center/Program Affiliation

Center for Neuroscience

Education

M.D., George Washington University, Washington DC 1982

B.S., UC Santa Barbara, Santa Barbara CA 1978

Residency

George Washington University Medical Center, Washington DC 1982-1984

Strong Memorial Hospital, Rochester NY 1984-1987

Fellowships

National Institute on Aging, Bethesda MD 1987-1989

Board Certifications

American Board of Neurology and Psychiatry,

American Medical EEG Association - Electroencephalography,

Professional Memberships

Alzheimer's Disease Association, Neuroimaging Work Group

Alzheimer's Imaging Consortium

American Academy of Neurology

American Association for the Advancement of Science

American Heart Association

International Society for Vascular Behavioral and Cognitive Disorders

Society for Neuroscience

Honors and Awards

UC Davis School of Medicine Research Award, 2018

A Sacramento Best Doctor, 2015

Resident Education Teaching Award, �Excellence in Inpatient Teaching�, UC Davis Department of Neurology, 2014

Victor and Genevieve Orsi Chair in Alzheimer�s Research, 2012

Mayo Clinic Visiting Professor, 2012

Select Recent Publications

Fletcher E, DeCarli C, Fan AP, Knaack A. Convolutional Neural Net Learning Can Achieve Production-Level Brain Segmentation in Structural Magnetic Resonance Imaging. Front Neurosci. 2021 Jun 21;15:683426. doi:10.3389/fnins.2021.683426. PMID:34234642.

Peterson RL, George KM, Gilsanz P, Ackley S, Mayeda ER, Glymour MM, Mungas DM, DeCarli C, Whitmer RA. Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains: The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study. Alzheimer Dis Assoc Disord. 2021 Apr-Jun 01;35(2):99-105. doi:10.1097/WAD.0000000000000436. PMID:34006727.

Granot-Hershkovitz E, Tarraf W, Kurniansyah N, Daviglus M, Isasi CR, Kaplan R, Lamar M, Perreira KM, Wassertheil-Smoller S, Stickel A, Thyagarajan B, Zeng D, Fornage M, DeCarli CS, González HM, Sofer T. APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL). Alzheimers Dement. 2021 Mar;17(3):466-474. doi:10.1002/alz.12205. Epub 2020 Nov 6. PMID:33155766.

Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP, Himali JJ. Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample. Neurology. 2021 Mar 9;96(10):e1462-e1469. doi:10.1212/WNL.0000000000011377. Epub 2020 Dec 22. PMID:33361258.

Lesman-Segev OH, La Joie R, Iaccarino L, Lobach I, Rosen HJ, Seo SW, Janabi M, Baker SL, Edwards L, Pham J, Olichney J, Boxer A, Huang E, Gorno-Tempini M, DeCarli C, Hepker M, Hwang JL, Miller BL, Spina S, Grinberg LT, Seeley WW, Jagust WJ, Rabinovici GD. Diagnostic Accuracy of Amyloid versus <sup>18</sup> F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia. Ann Neurol. 2021 Feb;89(2):389-401. doi10.1002/ana.25968. Epub 2020 Dec 7. PMID:33219525.

Shoamanesh A, Akoudad S, Himali JJ, Beiser AS, DeCarli C, Seshadri S, Ikram MA, Romero JR, Vernooij MW. Cortical superficial siderosis in the general population: The Framingham Heart and Rotterdam studies. Int J Stroke. 2021 Jan 21:1747493020984559. doi:10.1177/1747493020984559. Epub ahead of print. PMID:33478376.

Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 Jan 20;13(577):eabc0655. doi:10.1126/scitranslmed.abc0655. PMID:33472953.

Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 Jan 1;78(1):102-113. doi:10.1001/jamaneurol.2020.3536. PMID:33074286.

Gonzales MM, Samra J, O'Donnell A, Mackin RS, Salinas J, Jacob ME, Satizabal CL, Aparicio HJ, Thibault EG, Sanchez JS, Finney R, Rubinstein ZB, Mayblyum DV, Killiany RJ, DeCarli CS, Johnson KA, Beiser AS, Seshadri S. Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study. J Alzheimers Dis. 2021;82(1):249-260. doi:10.3233/JAD-210232. PMID:34024836.

Wright CB, DeRosa JT, Moon MP, Strobino K, DeCarli C, Cheung YK, Assuras S, Levin B, Stern Y, Sun X, Rundek T, Elkind MSV, Sacco RL. Race/Ethnic Disparities in Mild Cognitive Impairment and Dementia: The Northern Manhattan Study. J Alzheimers Dis. 2021;80(3):1129-1138. doi:10.3233/JAD-201370. PMID:33646162.