William Ridgway, M.D.
Chief, Department of Internal Medicine, Division of Rheumatology, Allergy & Clinical Immunology
To see if William Ridgway is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Specialties
Rheumatology
Rheumatology, Allergy and Clinical Immunology
Department
Locations and Contact
Lawrence J. Ellison Ambulatory Care Center
Lawrence J. Ellison Ambulatory Care Center
4860 Y St.
Sacramento, CA 95817
Additional Numbers
Clinic Phone
Clinic Fax
Physician Referrals
Philosophy of Care
Many patients with autoimmune and rheumatological diseases suffer for years before a proper diagnosis is made. The history of the illness is critical to establishing a proper diagnosis in rheumatology. I emphasize a detailed history and physical examination, with confirmatory laboratory and radiological studies. Once the diagnosis is established, I believe in an evidence-based approach to treatment, emphasizing the scientific literature whenever possible (some rheumtological conditions are so rare that controlled studies are lacking).
The treatment options available in rheumatology have expanded greatly in recent years, and patients resistant to conventional therapy can now be treated with a wide variety of novel biological therapies, often specifically targeted to the immunological basis of their disease. This gives us many tools to achieve our goal of suppressing inflammation as much as possible, thereby reducing disease activity so that the patient can resume their usual activities and lifestyle.
Clinical Interests
Dr. Ridgway is a rheumatologist, specializing in diagnosis and treatment of autoimmune and inflammatory rheumatological diseases.
Research/Academic Interests
Dr. Ridgway's laboratory research focuses on the immunogenetic basis of autoimmune disease, with the goal of developing novel, disease specific immunotherapies.
Division
Rheumatology, Allergy and Clinical Immunology
Center/Program Affiliation
Undergraduate School
B.A., Liberal Arts, Haverford College, Haverford PA 1982
Medical School
M.D., University of Rochester School of Medicine, Rochester NY 1989
Internship
Internal Medicine, Stanford University Hospital, Stanford CA 1989-1990
Residency
Internal Medicine, Stanford University Hospital, Stanford CA 1990-1992
Fellowship
Immunology, Howard Hughes Medical Institute, Stanford CA 1993-1996
Fellowship
Rheumatology, Immunology, Stanford University Hospital, Stanford CA 1992-1994
Fellowship
Immunology, Stanford University School of Medicine, Stanford CA 1993-1998
The Jack and Donald Chia Endowed Professor of Medicine, 2020
Department of IM Distinguished Research Achievement Award, 2013
Alice W. and Mark A. Brown Endowed Chair of Internal Medicine, 2010
Howard Hughes Medical Institute, Post doctoral Fellow, Stanford University, 1993
Pfizer Faculty Scholar, Immunology/Rheumatology, Juvenile Diabetes Foundation International Career Development Award, 1989
Adams DE, Heuer LS, Rojas M, Zhang W, Ridgway WM. Mutated Pkhd1 alone is sufficient to cause autoimmune biliary disease on the nonobese diabetic (NOD) genetic background. Immunogenetics. 2023 Feb;75(1):27-37. doi:10.1007/s00251-022-01276-3. Epub 2022 Sep 13. PMID:36097289.
Zhang W, Shao T, Leung PSC, Tsuneyama K, Heuer L, Young HA, Ridgway WM, Gershwin ME. Dual B-cell targeting therapy ameliorates autoimmune cholangitis. J Autoimmun. 2022 Oct;132:102897. doi:10.1016/j.jaut.2022.102897. Epub 2022 Aug 24. PMID:36029718.
Shao T, Leung PSC, Zhang W, Tsuneyama K, Ridgway WM, Young HA, Shuai Z, Ansari AA, Gershwin ME. Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression. Cell Mol Immunol. 2022 Oct;19(10):1130-1140. doi:10.1038/s41423-022-00904-y. Epub 2022 Aug 30. PMID:36042351.
Rojas M, Heuer LS, Zhang W, Chen YG, Ridgway WM. The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes. Front Immunol. 2022 Jul 22;13:918837. doi:10.3389/fimmu.2022.918837. PMID:35935980.
Locker KCS, Kachapati K, Wu Y, Bednar KJ, Adams D, Patel C, Tsukamoto H, Heuer LS, Aronow BJ, Herr AB, Ridgway WM. Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes. Diabetes. 2022 Mar 1;71(3):470-482. doi:10.2337/db21-0426. PMID:35040474.
Yang Y, Choi J, Chen Y, Invernizzi P, Yang G, Zhang W, Shao TH, Jordan F, Nemeria NS, Coppel RL, Ridgway WM, Kurth M, Ansari AA, Leung PSC, Gershwin ME. E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants. Hepatology. 2022 Feb;75(2):266-279. doi:10.1002/hep.32172. Epub 2021 Dec 12. PMID:34608663.
Chen Z, Zhang W, Selmi C, Ridgway WM, Leung PSC, Zhang F, Gershwin ME. The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function. Autoimmun Rev. 2021 Nov;20(11):102942. doi:10.1016/j.autrev.2021.102942. Epub 2021 Sep 10. PMID:34509657.
Li M, Itoh A, Xi J, Yu C, Wu Y, Ridgway WM, Liu H. Enhancing Antigen Presentation and Inducing Antigen-Specific Immune Tolerance with Amphiphilic Peptides. J Immunol. 2021 Oct 15;207(8):2051-2059. doi:10.4049/jimmunol.1901301. Epub 2021 Sep 15. PMID:34526376.
Itoh A, Adams D, Huang W, Wu Y, Kachapati K, Bednar KJ, Leung PSC, Zhang W, Flavell RA, Gershwin ME, Ridgway WM. Enoxacin Up-Regulates MicroRNA Biogenesis and Down-Regulates Cytotoxic CD8 T-Cell Function in Autoimmune Cholangitis. Hepatology. 2021 Aug;74(2):835-846. doi:10.1002/hep.31724. Epub 2021 Aug 10. PMID:33462854.
Rodríguez Y, Novelli L, Rojas M, De Santis M, Acosta-Ampudia Y, Monsalve DM, Ramírez-Santana C, Costanzo A, Ridgway WM, Ansari AA, Gershwin ME, Selmi C, Anaya JM. Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. J Autoimmun. 2020 Nov;114:102506. doi:10.1016/j.jaut.2020.102506. Epub 2020 Jun 16. PMID:32563547.