Elena A. Goncharova, Ph.D., A.T.S.F.
Professor, Department of Internal Medicine
Locations and Contact
Genome and Biomedical Sciences Building
Genome & Biomedical Sciences Facility
451 Health Sciences Dr
Davis, CA 95616
Phone: 530-752-2884
Additional Numbers
Physician Referrals
Research/Academic Interests
Dr. Goncharova has a long standing interest in basic and translational pulmonary vascular research and she serves as a Director of Pulmonary Vascular Disease Program. Dr. Goncharova’s research interests has focused on molecular and cellular mechanisms of pulmonary arterial hypertension (PAH) with specific focus on the role mTOR, HIPPO and GATA6 signaling networks and cancer-like smooth muscle remodeling in PAH as well as on identifying novel molecular targets to reverse established pulmonary vascular disease.
Division
Undergraduate School
M.S., Biology, Moscow Lomonosov State University, Moscow, Russia 1993
Other School
Ph.D., Biology, Cardiology Research Center, Russian Academy of Sciences, Moscow, Russia 2000
Fellowship
Signal Transductions Smooth Muscle Biology, University of Pennsylvania, Philadelphia PA 2001-2005
Recognition as an Expertscape Expert in Pulmonary Arterial Hypertension, 2021
The American Thoracic Society Fellow designation, 2020
The AJRCCM Eminent Reviewer Award, American Thoracic Society, 2019
University of Pittsburgh VMI-HVI Innovator Award, Vascular Medicine Institute, University of Pittsburgh, 2014
Parker B. Francis Fellowship Award, Parker B. Francis Fellowship Program, 2008
Complete list of published work (Pubmed): http://www.ncbi.nlm.nih.gov/sites/myncbi/elena.goncharova.1/bibliography/43883529/public/?sort=date&direction=ascending
Kudryashova TV, Goncharova EA. MonOrail to Cure? Targeting Orai1 to Reverse Pulmonary Arterial Hypertension. Circ Res. 2022 Oct 14;131(9):728-730. doi:10.1161/CIRCRESAHA.122.321924. Epub 2022 Oct 13. PMID:36252052.
Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circ Res. 2022 Mar 4;130(5):760-778. doi:10.1161/CIRCRESAHA.121.319100. Epub 2022 Feb 7. PMID:35124974.
Shen Y, Goncharov DA, Pena A, Baust J, Barragan AC, Ray A, Rode A, Bachman T, Chang B, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. TSC2-extracellular matrix crosstalk controls pulmonary vascular proliferation and pulmonary hypertension. Science Signaling. 2022;15(763):eabn2743.
Goncharova EA, Chan SY, Ventetuolo CE, Weissmann N, Schermuly RT, Mullin CJ, Gladwin MT. Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction 2019. Am J Respir Crit Care Med. 2020 Jul 1;202(1):22-28. doi:10.1164/rccm.202003-0576UP. PMID:32311291.
Goncharova EA, Simon MA, Yuan JX. mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Am J Respir Crit Care Med. 2020 May 15;201(10):1177-1179. doi:10.1164/rccm.202001-0087ED. PMID:31968178.
Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC. Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Sep 1;198(5):681-684. doi:10.1164/rccm.201801-0022LE. PMID:29727194.
Pullamsetti SS, Savai R, Seeger W, Goncharova EA. Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs. Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi:10.1164/rccm.201606-1226PP. PMID:27627135.
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877. doi:10.1164/rccm.201510-2003OC. PMID:27119551.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension. Circulation. 2014 Feb 25;129(8):864-74. doi:10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22. PMID:24270265.