Tatiana V. Kudryashova, M.S., Ph.D.
Assistant Adjunct Professor
Locations and Contact
Genome and Biomedical Sciences Building
Genome & Biomedical Sciences Facility
451 Health Sciences Dr
Davis, CA 95616
Phone: 530-752-2884
Additional Numbers
Clinic Fax
Clinic Referral Phone
Physician Referrals
Research/Academic Interests
Dr. Kudryashova's research interests are focused on investigation of molecular and cellular mechanisms of pulmonary arterial hypertension (PAH), especially mechanisms of pulmonary vascular remodeling. Dr. Kudryashova's long-standing research interests are focused on investigating sex-specific mechanisms of pulmonary vascular remodeling and role of extracellular matrix in PAH and development of therapeutic treatment, which can attenuate pulmonary vascular remodeling in PAH.
Division
Other School
M.S., Biochemistry, Lomonosov Moscow State University, School of Biology, Moscow, Russia 2004
Other School
Ph.D., Biochemistry, Moscow State University, Moscow, Russia 2011
Pulmonary Vascular Research Institute, 14th Annual World Congress on Pulmonary Vascular Disease, Lima, Peru, Award, 2020
Instructor's competition, Moscow State University, Moscow, Russia, 3rd Award, 2012
British Society for Cell Biology, 6th Abercrombie Meeting on Cell Migration: from Molecules to Organisms, Oxford, UK, Award, 2007
Shen Y, Goncharov DA, Pena A, Baust J, Chavez Barragan A, Ray A, Rode A, Bachman TN, Chang B, Jiang L, Dieffenbach P, Fredenburgh LE, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Sci Signal. 2022 Dec 6;15(763):eabn2743. doi:10.1126/scisignal.abn2743. Epub 2022 Dec 6. PMID:36473049.
Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA, Kudryashova TV. Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Front Med (Lausanne). 2022 Jun 28;9:886868. doi:10.3389/fmed.2022.886868. PMID:35836951.
Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circ Res. 2022 Mar 4;130(5):760-778. doi:10.1161/CIRCRESAHA.121.319100. Epub 2022 Feb 7. PMID:35124974.
Shen Y, Goncharov DA, Avolio T, Ray A, Okorie E, DeLisser H, Mora AL, Vanderpool R, Kudryashova TV, Goncharova EA. Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats. Pulm Circ. 2020 Feb 12;10(1):2045894019898593. doi:10.1177/2045894019898593. PMID:32110386.
Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA. Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Sep 28;19(10):2957. doi:10.3390/ijms19102957. PMID:30274147.
Mochalov SV, Tarasova NV, Kudryashova TV, Gaynullina DK, Kalenchuk VU, Borovik AS, Vorotnikov AV, Tarasova OS, Schubert R. Higher Ca2+ -sensitivity of arterial contraction in 1-week-old rats is due to a greater Rho-kinase activity. Acta Physiol (Oxf). 2018 Jul;223(3):e13044. doi:10.1111/apha.13044. Epub 2018 Feb 17. PMID:29383848.
Pena A, Kobir A, Goncharov D, Goda A, Kudryashova TV, Ray A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J 3rd, Goncharova EA. Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats. Am J Respir Cell Mol Biol. 2017 Nov;57(5):615-625. doi:10.1165/rcmb.2016-0364OC. PMID:28679058.
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877. doi:10.1164/rccm.201510-2003OC. PMID:27119551.
Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA. Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension. Pulm Circ. 2015 Dec;5(4):667-80. doi:10.1086/683810. PMID:26697174.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension. Circulation. 2014 Feb 25;129(8):864-74. doi:10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22. PMID:24270265.