David A. Liem, M.D., Ph.D.
Associate Professor, Division of Cardiovascular Medicine
To see if David A. Liem is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Locations and Contact
Lawrence J. Ellison Ambulatory Care Center
Lawrence J. Ellison Ambulatory Care Center
4860 Y St.
Sacramento, CA 95817
Additional Numbers
Clinic Phone
Clinic Fax
Clinic Referral Phone
Philosophy of Care
Dr. Liem is interested in the emerging field of precision medicine and the use of computational biomedicine to approach every heart disease in a holistic manner considering multiple layers, biological systems, and molecular networks within a patient's whole body. Dr. Liem is studying the concept of "total medicine" in which each patient is approached from multiple disciplines in basic (translational) science, computational biology, clinical (trial) research, and patient care.
Clinical Interests
Dr. Liem has a special interest in heart failure with preserved ejection fraction (often abbreviated as HFpEF) and how certain risk factors such as obesity, diabetes, hypertension (together known as metabolic syndrome), and chronic kidney disease affect the clinical presentation and outcome of patients with this disease. Dr. Liem is also interested in novel therapeutic strategies for HFpEF patients, such as sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) and mineralocorticoids.
Research/Academic Interests
As a physician-scientist in cardiovascular medicine, Dr. Liem's focus has been in basic (translational) science combining cardiovascular research with computational biology. He has an expertise in the pathophysiology of ischemic heart disease (ischemia-reperfusion injury), and cardiomyopathies leading to heart failure (HFrEF, HFmEF, HFpEF). Dr. Liem has been conducting strategies in computational biomedicine and text mining to uncover molecular (multi-omics) underpinnings and biological pathways via data science and bioinformatics approaches. Dr. Liem is currently studying how social determinants of health (SDoH) affect the clinical phenotypes and outcomes in heart failure patients.
Division
Cardiovascular Medicine
Center/Program Affiliation
Undergraduate School
B.S./M.S., Medicine, Erasmus University, Rotterdam Netherlands 1998
Medical School
M.D., Medicine, Erasmus Medical Center, Rotterdam Netherlands 2000
Other School
Ph.D., Experimental Cardiology/ Biophysics, Erasmus Medical Center, Rotterdam Netherlands 2003
Internship
Internal Medicine/ Cardiovascular Disease, Erasmus Medical Center, Rotterdam Netherlands 1998 - 2000
Fellowship
Cardiovascular Disease/ CT Surgery, Academic Medical Center, Amsterdam Netherlands 2003
Fellowship
Cardiovascular Disease/ Physiology, UCLA Medical Center, Los Angeles CA 2003-2009
Trainee Abstract Award, Annual Symposium Scientific Sessions of The American Heart Association, 2007,
New Investigator Award, The American Heart Association Council on Basic Cardiovascular Sciences, 2010,
Liem DA, Silva H, Romero E, Rocha P, Acevedo PE, Izu MR, Ballal A, Soroya M, López JE, Nuno MA, Quazi A, Mukherjee C, Linklater W, Ebong I, Zhang XD, Izu LT, Sirish P, Chiamvimonvat N, Cadeiras M. Association of Neighborhood and Environmental Factors With Clinical Phenotypes and Outcomes in Heart Failure With Preserved Ejection Fraction. Circ Res. 2024 Jun 21;135(1):155-158. PubMed PMID: 38759107
Liem DA, Cadeiras M, Setty SP. Insights and perspectives into clinical biomarker discovery in pediatric heart failure and congenital heart disease-a narrative review. Cardiovasc Diagn Ther. 2023 Feb 28;13(1):83-99. doi: 10.21037/cdt-22-386. Epub 2023 Jan 9. Review. PubMed PMID: 36864972
Liem DA, Murali S, Sigdel D, Shi Y, Wang X, Shen J, Choi H, Caufield JH, Wang W, Ping P, Han J. Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H910-H924. doi: 10.1152/ajpheart.00175.2018. Epub 2018 May 18. PubMed PMID: 29775406
McClatchy DB, Ma Y, Liem DA, Ng DCM, Ping P, Yates JR 3rd. Quantitative temporal analysis of protein dynamics in cardiac remodeling. J Mol Cell Cardiol. 2018 Aug;121:163-172. doi: 10.1016/j.yjmcc.2018.07.126. Epub 2018 Jul 19. PubMed PMID: 30009778
*Liem DA, *Wang D, Lau E, Ng DC, Bleakley BJ, Cadeiras M, Deng MC, Lam MP, Ping P. Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clin Appl. 2014 Aug;8(7-8):610-9. doi: 10.1002/prca.201400038. PubMed PMID: 24946186; PubMed Central PMCID: PMC4764616. (* shared first author)
Gago-Lopez N, Awaji O, Zhang Y, Ko C, Nsair A, Liem DA, Stempien-Otero A, MacLellan WR. THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential. Stem Cell Reports. 2014 May 6;2(5):576-91. doi: 10.1016/j.stemcr.2014.03.003. eCollection 2014 May 6. PubMed PMID: 24936447
*Liem DA, *Lam MP, *Wang D, *Lau E, Kim AK, Ng DC, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadeiras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest. 2014 Apr;124(4):1734-44. doi: 10.1172/JCI73787. Epub 2014 Mar 10. PubMed PMID: 24614109 (* shared first author)
Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC. Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support. Circ Heart Fail. 2014 Mar 1;7(2):359-66. doi: 10.1161/CIRCHEARTFAILURE.113.000250. Review. PubMed PMID: 24643888
Drews O, Tsukamoto O, Liem DA, Streicher J, Wang Y, Ping P. Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. Circ Res. 2010 Oct 29;107(9):1094-101. doi: 10.1161/CIRCRESAHA.110.222364. Epub 2010 Sep 2. PubMed PMID: 20814020
Liem DA, Zhao P, Angelis E, Chan SS, Zhang J, Wang G, Berthet C, Kaldis P, Ping P, MacLellan WR. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol. 2008 Nov;45(5):610-6. doi: 10.1016/j.yjmcc.2008.07.003. Epub 2008 Jul 18. PubMed PMID: 18692063