Associate Adjunct Professor
Director, Stem Cell Core
UC Davis Comprehensive Cancer Center
2279 45th Street
Sacramento, CA 95817
Phone: 916-734-5959
Dr. Zhou's research focuses on stem cells and their applications for regenerative medicine, with special emphasis on pluripotent stem cells, mesenchymal stem cells and hematopoietic stem cells to create innovative treatment of liver disease, vascular diseases and hemophilia. Efforts have also been made to understanding the mechanisms that regulate cell lineage commitment during the differentiation of pluripotent stem cells to different cell types. Generation of vascularized organoids from pluripotent stem cells for transplantation or drug screening is another area of Dr. Zhou's research.
Malignant Hematology/Cellular Therapy and Transplantation
Hematology and Oncology
B.S., Chongqing University of Medical Sciences, Chongqing, China 1985
Ph.D., Molecular Biology, University of Illinois at Chicago, Chicago IL 1999
Innovative Development Award, UC Davis, 2012, 2018
Abby S. and Howard P. Milstein Foundation Fellow, Abby S. and Howard P. Milstein Foundation, 2017
Hao D, Lu L, Song H, Duan Y, Chen J, Carney R, Li JJ, Zhou P, Nolta J, Lam KS, Leach JK, Farmer DL, Panitch A, Wang A. Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair. Theranostics. 2022 Aug 8;12(13):6021-6037. doi:10.7150/thno.70448. PMID:35966577.
Li T, Wu H, Wang P, Kim AM, Jia J, Nolta JA, Zhou P. HDACs regulate the differentiation of endothelial cells from human iPSCs. Cell Biochem Funct. 2022 Aug;40(6):589-599. doi:10.1002/cbf.3729. Epub 2022 Jul 5. PMID:35789099.
Rose M, Gao K, Cortez-Toledo E, Agu E, Hyllen AA, Conroy K, Pan G, Nolta JA, Wang A, Zhou P. Endothelial cells derived from patients’ induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A. Stem Cells Transl Med. 2020 Mar 12;9(6):686-696. doi:10.1002/sctm.19-0261. PMID:32162786.
Gao K, Kumar P, Cortez-Toledo E, Hao D, Reynaga L, Rose M, Wang C, Farmer D, Nolta J, Zhou J, Zhou P, Wang A. Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells. Stem Cell Res Ther. 2019 Jan 22;10(1):34. doi:10.1186/s13287-019-1138-8. PMID:30670078.
Cortez-Toledo E, Rose M, Agu E, Dahlenburg H, Yao W, Nolta JA, Zhou P. Enhancing Retention of Human Bone Marrow Mesenchymal Stem Cells with Prosurvival Factors Promotes Angiogenesis in a Mouse Model of Limb Ischemia. Stem Cells Dev. 2019 Jan 15;28(2):114-119. doi:10.1089/scd.2018.0090. Epub 2018 Dec 18. PMID:30398391.
Pham MT, Pollock KM, Rose MD, Cary WA, Stewart HR, Zhou P, Nolta JA, Waldau B. Generation of human vascularized brain organoids. Neuroreport. 2018 May 2;29(7):588-593. doi:10.1097/WNR.0000000000001014. PMID:29570159.
Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086. doi:10.1021/acschembio.7b00118. Epub 2017 Mar 2. PMID:28195700.
Harding A, Cortez-Toledo E, Magner NL, Beegle JR, Coleal-Bergum DP, Hao D, Wang A, Nolta JA, Zhou P. Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017 Apr;35(4):909-919. doi: 10.1002/stem.2577. Epub 2017 Mar 1. PMID: 28248004.
Beegle JR, Magner NL, Kalomoiris S, Harding A, Zhou P, Nacey C, White JL, Pepper K, Gruenloh W, Annett G, Nolta JA, Fierro FA. Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia. Mol Ther Methods Clin Dev. 2016 Aug 24;3:16053. doi:10.1038/mtm.2016.53. PMID:27610394.
Chen J, Gao W, Zhou P, Ma X, Tschudy-Seney B, Liu C, Zern MA, Liu P, Duan Y. Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu. Scientific Reports. 2015;6:18841. doi:10.1038/srep18841. PMID:26733102.