Valentina Medici, M.D., M.A.S., F.A.A.S.L.D.
Vice Chair for Research
CTSC TL1 Program PI/Director
Professor
To see if Valentina Medici is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Locations and Contact
UC Davis Midtown Ambulatory Care Center
Midtown GI Clinic
3160 Folsom Blvd
Sacramento, CA 95816
Phone: 916-734-0779
Philosophy of Care
My phylosophy of care is that I work together with my patients to achieve a desired goal. I think that communication and very respectful and compassionate interaction are crucial to medical practice. The field of medicine and hepatology are rapidly evolving and I strive to provide the most updated information and care to my patients. At the end of the day, I want my patients to be very satisfied and comfortable with the care they received in our clinics and I apply my best knowledge, experience, and judgment to each situation I encounter.
Clinical Interests
Dr. Medici specializes in the care of liver diseases, with particular focus on metabolic diseases. In particular, she has special clinical and research interest in Wilson disease. She also follows patients with fatty liver, alcohol-associated liver disease, post liver transplant patients, and patients with nutrition problems.
Research/Academic Interests
Dr. Medici has devoted her research career to the study of Wilson disease and particulary to the epigenetic changes that can affect the clinical manifestations of this rare disease. She also conducts research in liver metabolism and lipid profiles in patients from different ethnic backgrounds. Her research spans human, translational, and basic science studies in animal models. The ultimate goal of her research is the understanding of the pathophysiology of liver diseases to improve their diagnosis and treatment.
Division
Gastroenterology and Hepatology
Center/Program Affiliation
Undergraduate School
Tito Livio, Liceo Classico, Padova, Italy 1994
Medical School
M.D., University of Padova School of Medicine, Padova Italy 2000
Other School
M.A.S., Clinical Research, UC Davis School of Medicine, Sacramento CA 2008
Internship
Gastroenterology and Hepatology, University of Padova, Padova, Italy 2000-2004
Residency
Gastroenterology and Hepatology, University of Padova, Padova, Italy 2000-2004
Fellowship
Gastroenterology, University of Kiel, Kiel, Germany 2002-2003
Fellowship
Gastroenterology and Hepatology, University of Padova, Padova, Italy 2000-2004
Internal Medicine, Chairs Recognition Award, 2019
UC Davis CTSC TL1 pre- and post-doctoral students Clinical Research Training Program PI/Director, 2019
National Institutes of Health - NIDDK - R01, 2015
Fred and Pat Anderson Endowed Chair in Liver Research (2015-present), 2015
UC Davis Internal Medicine Faculty Research Award, 2015
Medici V, Czlonkowska A, Litwin T, Giulivi C. Diagnosis of Wilson Disease and Its Phenotypes by Using Artificial Intelligence. Biomolecules. 2021 Aug 20;11(8):1243. doi:10.3390/biom11081243. PMID:34439909.
Sarode GV, Neier K, Shibata NM, Shen Y, Goncharov DA, Goncharova EA, Mazi TA, Joshi N, Settles ML, LaSalle JM, Medici V. Wilson Disease: Intersecting DNA Methylation and Histone Acetylation Regulation of Gene Expression in a Mouse Model of Hepatic Copper Accumulation. Cell Mol Gastroenterol Hepatol. 2021;12(4):1457-1477. doi:10.1016/j.jcmgh.2021.05.020. Epub 2021 Jun 4. PMID:34098115.
Mazi TA, Borkowski K, Newman JW, Fiehn O, Bowlus CL, Sarkar S, Matsukuma K, Ali MR, Kieffer DA, Wan YY, Stanhope KL, Havel PJ, Medici V. Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study. Free Radic Biol Med. 2021 Aug 20;172:490-502. doi:10.1016/j.freeradbiomed.2021.06.024. Epub 2021 Jun 25. PMID:34182070.
Harder NHO, Hieronimus B, Stanhope KL, Shibata NM, Lee V, Nunez MV, Keim NL, Bremer A, Havel PJ, Heffern MC, Medici V. Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans. Nutrients. 2020 Aug 25;12(9):2581. doi:10.3390/nu12092581. PMID:32854403.
Sarode GV, Kim K, Kieffer DA, Shibata NM, Litwin T, Czlonkowska A, Medici V. Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature. Metabolomics. 2019 Mar 12;15(3):43. doi:10.1007/s11306-019-1505-6. Erratum in: Metabolomics. 2019 Dec 3;16(1):3. PMID:30868361.
Mordaunt CE, Kieffer DA, Shibata N, Czlonkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus C, Sarkar S, Cooper S, Wan YJ, Mohamed A, LaSalle J, Medici V. Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. Epigenetics Chromatin. 2019; 12(1):10. doi:10.1186/s13072-019-0255-z.
Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. Hum Mol Genet. 2018 Nov 15;27(22):3854-3869. doi:10.1093/hmg/ddy262. PMID:30010856.
Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Nov;11(11):804-818. doi:10.1080/15592294.2016.1231289. Epub 2016 Sep 9. PMID:27611852.
Syed R, Shibata NM, Kharbanda KK, Su RJ, Olson K, Yokoyama A, Rutledge JC, Chmiel KJ, Kim K, Halsted CH, Medici V. Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice. Metab Syndr Relat Disord. 2016 May;14(4):202-9. doi:10.1089/met.2015.0147. Epub 2016 Feb 16. PMID:26881897.
Butler AA, St-Onge MP, Siebert EA, Medici V, Stanhope KL, Havel PJ. Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans. Sci Rep. 2015 Oct 5;5:14691. doi:10.1038/srep14691. PMID:26435060.