Jerold A. Last, Ph.D.
Distinguished Professor Emeritus, Department of Internal Medicine
Specialties
Internal Medicine
Pulmonary and Critical Care
Biochemistry
Department
Locations and Contact
Genome and Biomedical Sciences Building
Genome & Biomedical Sciences Facility
451 Health Sciences Dr
Davis, CA 95616
Phone: 530-752-2884
Research/Academic Interests
Dr. Last's research interests focus on the regulation of protein synthesis, animal models of acute and chronic lung fibrosis, collagen biochemistry, lung toxicology and asthma.
Division
Undergraduate School
B.S., Chemistry, University of Wisconsin, Madison WI 1959
Other School
Ph.D., Biochemistry, Ohio State University College of Medicine, Columbus OH 1965
Other School
M.S., Biochemistry, University of Wisconsin, Madison WI 1961
Fellowship
Chemistry: Collagen Synthesis, Harvard University, Cambridge MA 1973-1976
Fellowship
Biochemistry: Genetic Code, New York University, New York NY 1966-1967
UC Davis Health System, Dean's Award for Excellence in Mentoring, 2005
UC Davis Distinguished Public Service Award, 2003
Fulbright Lecturer Awards, Uruguay and Argentina, 1982, 1999
School of Medicine Faculty Research Award, 1990
Zeki AA, Oldham J, Wilson M, Fortenko O, Goyal V, Last M, Last A, Patel A, Last JA, Kenyon NJ. Statin use and asthma control in patients with severe asthma. BMJ Open. 2013 Aug 13;3(8):e003314. doi:10.1136/bmjopen-2013-003314. PMID:23943778.
Cardozo S, González-Techera A, Last JA, Hammock BD, Kramer K, González-Sapienza GG. Analyte peptidomimetics selected from phage display peptide libraries: a systematic strategy for the development of environmental immunoassays. Environ Sci Technol. 2005 Jun 1;39(11):4234-41. doi:10.1021/es047931l. PMID:15984805.
Armstrong LC, Last JA. Rat lysyl hydroxylase: molecular cloning, mRNA distribution and expression in a baculovirus system. Biochim Biophys Acta. 1995 Oct 17;1264(1):93-102. doi:10.1016/0167-4781(95)00130-9. PMID:7578263.
Gerriets JE, Curwin SL, Last JA. Tendon hypertrophy is associated with increased hydroxylation of nonhelical lysine residues at two specific cross-linking sites in type I collagen. J Biol Chem. 1993 Dec 5;268(34):25553-60. PMID:8244992.
Last JA, King TE Jr, Nerlich AG, Reiser KM. Collagen cross-linking in adult patients with acute and chronic fibrotic lung disease. Molecular markers for fibrotic collagen. Am Rev Respir Dis. 1990 Feb;141(2):307-13. doi:10.1164/ajrccm/141.2.307. PMID:2301849.
Reiser KM, Last JA. Type V collagen. Quantitation in normal lungs and in lungs of rats with bleomycin-induced pulmonary fibrosis. J Biol Chem. 1983 Jan 10;258(1):269-75. PMID:6184372.
Haschek WM, Klein-Szanto AJ, Last JA, Reiser KM, Witschi H. Long-term morphologic and biochemical features of experimentally induced lung fibrosis in the mouse. Lab Invest. 1982 Apr;46(4):438-49. PMID:7070057.
Silber R, Malathi VG, Hurwitz J. Purification and properties of bacteriophage T4-induced RNA ligase. Proc Natl Acad Sci U S A. 1972 Oct;69(10):3009-13. doi:10.1073/pnas.69.10.3009. PMID:4342972.
Boedtker H, Crkvenjakov RB, Last JA, Doty P. The identification of collagen messenger RNA. Proc Natl Acad Sci U S A. 1974 Oct;71(10):4208-12. doi:10.1073/pnas.71.10.4208. PMID:4530295.
Last JA, Stanley WM Jr, Salas M, Hille MB, Wahba AJ, Ochoa S. Translation of the genetic message, IV. UAA as a chain termination codon. Proc Natl Acad Sci U S A. 1967 Apr;57(4):1062-7. doi:10.1073/pnas.57.4.1062. PMID:5231346.