William Joseph Murphy, Ph.D. for UC Davis Health

William Joseph Murphy, Ph.D.

Distinguished Professor




Locations and Contact

UC Davis Institute for Regenerative Cures (IRC)

UC Davis Institute for Regenerative Cures (IRC)
2921 Stockton Blvd.
Sacramento, CA 95817

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Additional Numbers

Physician Referrals

800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Dr. Murphy does research on cancer immunotherapy.


Malignant Hematology/Cellular Therapy and Transplantation
Hematology and Oncology

Center/Program Affiliation

UC Davis Comprehensive Cancer Center

Undergraduate School

B.S., Rutgers University, New Brunswick NJ 1984

Other School

Ph.D., Immunology, University of Texas, Southwestern Medical School, Dallas TX 1989

UC Davis School of Medicine, Outstanding Researcher Award, 2016

UC Davis School of Medicine, Dean's Excellence in Mentoring Award, 2011

Nevada Business Journal Health Care Hero, 2007

ASC Scholar Award, 2002

NCI, Norman P. Saltzman Mentoring Award, 2000

Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier LL, Blazar BR, Redelman D, Murphy WJ. Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood. 2012 Mar 29;119(13):3073-83. doi:10.1182/blood-2011-07-369736. Epub 2012 Jan 17. PMID:22251483.

Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A, Blazar BR. Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. 2012 Feb 9;119(6):1570-80. doi:10.1182/blood-2011-07-364414. Epub 2011 Nov 9. PMID:22072556.

Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ. Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood. 2012 Feb 9;119(6):1590-8. doi:10.1182/blood-2011-08-374314. Epub 2011 Dec 19. PMID:22184406.

Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28;117(17):4501-10. doi:10.1182/blood-2010-10-310425. Epub 2011 Mar 8. PMID:21385853.

Barao I, Alvarez M, Ames E, Orr MT, Stefanski HE, Blazar BR, Lanier LL, Anderson SK, Redelman D, Murphy WJ. Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC. Blood. 2011 Jun 30;117(26):7032-41. doi:10.1182/blood-2010-11-316653. Epub 2011 Apr 15. PMID:21498673.

Barao I, Alvarez M, Redelman D, Weiss JM, Ortaldo JR, Wiltrout RH, Murphy WJ. Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2011 Dec;17(12):1754-64. doi:10.1016/j.bbmt.2011.08.023. Epub 2011 Sep 8. PMID:21906575.

Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS. Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood. 2011 Mar 24;117(12):3268-76. doi:10.1182/blood-2010-12-290403. Epub 2011 Jan 18. PMID:21245483.

Hu B, He Y, Wu Y, Bao G, Liu H, Welniak LA, Murphy WJ. Activated allogeneic NK cells as suppressors of alloreactive responses. Biol Blood Marrow Transplant. 2010 Jun;16(6):772-81. doi:10.1016/j.bbmt.2010.02.023. Epub 2010 Mar 1. PMID:20197103.

Orr MT, Murphy WJ, Lanier LL. 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. Nat Immunol. 2010 Apr;11(4):321-7. doi:10.1038/ni.1849. Epub 2010 Feb 28. PMID:20190757.

Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB. Hematopoietic progenitor cell regulation by CD4+CD25+ T cells. Blood. 2010 Jun 10;115(23):4934-43. doi:10.1182/blood-2009-04-218826. Epub 2010 Mar 3. PMID:20200356.