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Naoki Akanuma, M.D., Ph.D.
Health Sciences Assistant Clinical Professor
To see if Naoki Akanuma is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Specialties
Surgical Pathology - Head and Neck
Surgical Pathology - Gastrointestinal
Department
Locations and Contact
Philosophy of Care
My philosophy of care is to provide timely and precise services to enhance patient outcomes. I prioritize collaboration by working closely with clinical teams to ensure each patient receives the most accurate and personalized care.
Clinical Interests
Dr. Naoki Akanuma specializes in head and neck and gastrointestinal pathology, with a background in surgical oncology and gastrointestinal surgery. He has a particular interest in diagnosing and treating cancers in the head and neck region, as well as the digestive system.
Research/Academic Interests
Dr. Akanuma's research focuses on discovering diagnostic markers and exploring potential treatment targets for early head and neck and gastrointestinal cancers, as well as elucidating the mechanisms of cancer development, invasion, and metastasis.
Division
Anatomic Pathology
Medical School
M.D. Medicine, Chiba University School of Medicine, Chiba Japan 2005
Other School
Ph.D., Surgery, Chiba University Graduate School of Medical and Pharmaceutical Sciences, Chiba Japan 2014
Internship
General Surgery, Chiba Medical Center, Chiba Japan 2005-2007
Residency
General Surgery, Tokyo Women's University and Chiba Medical Center, Chiba Japan 2007-2011
Residency
Anatomic Pathology, University of California, San Francisco, San Francisco CA 2020-2024
Fellowship
Surgical Oncology/GI Surgery, Chiba University, Chiba Japan 2011-2014
Fellowship
Postdoctoral Research Fellowship, Harvard University Beth Israel Deaconess Medical Center, Boston MA 2018-2020
Fellowship
Surgical Pathology, University of California San Francisco, San Francisco CA 2023-2024
Fellowship
Gastrointestinal Pathology, University of California, San Francisco, San Francisco CA 2022-2023
Fellowship
Postdoctoral Research Fellowship, University of Texas Health Science Center at San Antonio, San Antonio TX 2014-2018
Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, and Choi WT. Fundic Gland Polyps in Familial Adenomatous Polyposis and Sporadic Patients Lack the DNA Content Abnormality that is Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract. Mod Pathol. 2023 Feb;36(5):100117. PMID: 36805791.
Xu Y, Nipper MH, Dominguez AA, Ye Z, Akanuma N, Lopez K, Deng JJ, Arenas D, Sanchez A, Sharkey FE, Court CM, Singhi AD, Wang H, Fernandez-Zapico ME, Sun LZ, Zheng S, Chen Y, Liu J, Wang P. Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset. Nat Commun. 2024 Jan 27;15(1):818. doi: 10.1038/s41467-024-45097-2. PMID: 38280869.
Kikuchi A*, Akanuma N*, Choi WT, Gill RM, Kakar S. Assessment of Large Droplet Fat in Frozen Sections of Donor Liver Biopsies: Utility and Interobserver Variability of the Newly Described Banff Method Compared to a Simplified Average of Fields Method. J Clin Pathol. 2023 Nov 24:jcp-2023-209237. PMID: 38053274.
Shibahara D*, Akanuma N*, Kobayashi IS, Heo E, Ando M, Fujii M, Jiang F, Prin PN, Pan G, Wong KK, Costa DB, Bararia D, Tenen DG, Watanabe H, Kobayashi SS. TIP60 is required for tumorigenesis in non-small cell lung cancer. Cancer Sci. 2023 Jun;114(6):2400-2413. PMID: 36916958.
Akanuma N, Joseph NM, Stachler M, Behr S, Takahashi T, and Gill RM. Malignant hepatic vascular neoplasm with novel RAF1 and GNA11 mutations: Risk stratification considerations for hepatic small vessel neoplasm (HSVN). Hum. Pathol: Case Rep. 2022 Sep; 29, 300671.
Akanuma N, Liu J, Liou G, Yin X, Bejar KR, Liu C, Sun L, Storz P, and Wang P. Paracrine Secretion of TGF-β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues. Pancreas. 2017 Oct; 46(9):1202–1207. PMID: 28902792.
Liu J, Akanuma N, Liu C, Naji A, Halff GA, Washburn WK, Sun L, and Wang P. TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Scientific Reports. 2016 Aug;6:30904. PMID: 27485764.
Akanuma N, Hoshino I, Akutsu Y, Murakami K, Isozaki Y, Maruyama T, Yusup G, Qin W, Toyozumi T, Takahashi M, Suito H, Hu X, Sekino N, and Matsubara M. MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer. Br J Cancer. 2014 Jan;110(1):189-98. PMID: 24196787.
Akanuma N, Hoshino I, Akutsu Y, Shuto K, Shiratori T, Kono T, Uesato M, Sato A, Isozaki Y, Maruyama T, Takeshita N, and Matsubara H. Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case. Surg Today. 2013 Apr;43(4):446-51. PMID: 22706784.
*These authors contributed equally.