Combinatorial libraries - Combinatorial Chemistry and Chemical Biology
Dr. Lam is the inventor of the one-bead one-compound (OBOC) combinatorial library method, and through the Combinatorial Chemistry Shared Resource he has been providing OBOC combinatorial libraries and support services to Cancer Center members. The OBOC method is highly efficient, both in compound synthesis and in library screening. Indeed, it is the ultra-high throughput method unmatched by any parallel synthesis methods. Many UC Davis investigators have developed successful grant proposals using this method.
In addition to OBOC libraries, the Combinatorial Chemistry Shared Resource has been providing solution-phase small molecule libraries to Cancer Center investigators. The technology involves the development of a novel polymer bead grafted with hydrophilic dendritic polymer on the bead surface such that these beads can be used for in situ solution-phase releasable assays. We can place compound-beads in a single small dish containing microbead high-density micro-well arrays for ultrahigh-throughput solution-phase releasable assays. Over 100,000 chemical compounds can be screened by a technician in a few days. More importantly, this OBOC chemical library method is relatively inexpensive and can be adapted to many existing cell-based or biochemical assays commonly used by many of our Cancer Center members.